| Identification | More | [Name]
2,4'-Dibromoacetophenone | [CAS]
99-73-0 | [Synonyms]
2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE
2-BROMO-1-(4-BROMOPHENYL)ETHANONE
4'-BROMOPHENACYL BROMIDE
4-BROMOPHENACYL BROMIDE
4,OMEGA-DIBROMOACETOPHENONE
AKOS BBS-00000865
ALPHA,4'-DIBROMOACETOPHENONE
ALPHA-4-DIBROMOACETOPHENONE
ALPHA,P-DIBROMOACETOPHENONE
A,P-DIBROMOACETOPHENONE
DIBROMOACETOPHENONE-2,4
GSK-3BETA INHIBITOR VII
OMEGA-BROMOACETOPHENONE
PBPB
P-BROMOPHENACYL BROMIDE
2,4’-dibromo-acetophenon
2-bromo-1-(4-bromophenyl)-ethanon
4,alpha-dibromoacetophenone
4-bromo(bromoacetyl)benzene
-4-Dibromoacetophenone | [EINECS(EC#)]
202-783-6 | [Molecular Formula]
C8H6Br2O | [MDL Number]
MFCD00000200 | [Molecular Weight]
277.94 | [MOL File]
99-73-0.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white crystals or powder | [Melting point ]
108-110 °C(lit.)
| [Boiling point ]
1415°C/760mm | [density ]
1.7855 (rough estimate) | [refractive index ]
1.5560 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol | [form ]
Crystalline Solid | [color ]
Slightly yellow to beige | [Stability:]
Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents. | [Water Solubility ]
Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water. | [Sensitive ]
Lachrymatory | [Merck ]
14,1427 | [BRN ]
607604 | [InChI]
1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2 | [InChIKey]
FKJSFKCZZIXQIP-UHFFFAOYSA-N | [SMILES]
BrCC(=O)c1ccc(Br)cc1 | [CAS DataBase Reference]
99-73-0(CAS DataBase Reference) | [EPA Substance Registry System]
99-73-0(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
2
| [RTECS ]
AM6950000
| [F ]
19-21 | [Hazard Note ]
Corrosive/Lachrymatory | [TSCA ]
T | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29147090 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
2,4'-Dibromoacetophenone is off-white crystals or powder
| [Uses]
Identification of carboxylic acids. | [Uses]
Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3 | [General Description]
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. | [Biochem/physiol Actions]
Cell permeable: yes | [Purification Methods]
Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.] |
|
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Alfa Aesar
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