| Identification | More | [Name]
3-Ethoxy-4-ethoxycarbonyl phenylacetic acid | [CAS]
99469-99-5 | [Synonyms]
2-(4-(ETHOXYCARBONYL)-3-ETHOXYPHENYL)ACETIC ACID
3-Ethoxy-4-(ethoxycarbonyl)benzeneacetic acid
3-ethoxy-4-ethoxycarbonyl phenylacetic acid
4-ETHOXYCARBONYL-3-ETHOXYPHENYLACETIC ACID
BENZENEACETIC ACID, 3-ETHOXY-4-(ETHOXYCARBONYL)-
REPAGLINIDE RELATED COMPOUND B (50 MG) (3-ETHOXY-4-ETHOXYCARBONYL-PHENYLACETIC ACID)
4-Ehtoxycarbonyl-3-Ehtoxyphynylacetic Acid
4-EHTOXYCARBONYL-3-EHTOXYPHYNYLACETIC ACID 98%
Repaglinide Intermediate 2
4-Ethoxycaybonyl-3-ethoxyphenyiaceticacid
Ethyl 4-(carboxymethyl)-2-ethoxybenzoate
ETHOXY-4-ETHOXYCARBONYLPHENYLACETIC ACID
4-ETHOXYCAYBONYL-3-ETHOXYPHENYIACETICACID[FOR REPAGLINIDE ]
4-EHTOXYCARBONYL-3-EHTOXYPHYNYLACETIC ACID, 97+% | [EINECS(EC#)]
427-630-2 | [Molecular Formula]
C13H16O5 | [MDL Number]
MFCD08704233 | [Molecular Weight]
252.26 | [MOL File]
99469-99-5.mol |
| Questions And Answer | Back Directory | [Synthesis]
Ethyl 2-ethoxy-4-methylbenzoate (3) was obtained by simultaneously esterifying the carboxyl group and etherifying the phenolic hydroxyl group of 4-methyl-2-hydroxybenzoic acid with diethyl sulfate. 3 was then reacted with lithium diisopropylamine (LDA) to form a methyl carbanion, which was subsequently carboxylated with ethyl chloroformate to obtain ethyl 3-ethoxy-4-ethoxycarbonylphenylacetate (4). This ethyl 3-ethoxycarbonylphenylacetate (4) was then selectively hydrolyzed to obtain 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid. The reaction route is short, and none of the intermediates require purification, with an overall yield of 58%. The synthetic route is shown in the figure below:  |
| Chemical Properties | Back Directory | [Appearance]
White to Pale Yellow Solid | [Melting point ]
78-80°C | [Boiling point ]
414.8±35.0 °C(Predicted) | [density ]
1.191 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
3.96±0.10(Predicted) | [color ]
White to Off-White | [Usage]
Repaglinide intermediate | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C13H16O5/c1-3-17-11-7-9(8-12(14)15)5-6-10(11)13(16)18-4-2/h5-7H,3-4,8H2,1-2H3,(H,14,15) | [InChIKey]
OTGSESBEJUHCES-UHFFFAOYSA-N | [SMILES]
C1(CC(O)=O)=CC=C(C(OCC)=O)C(OCC)=C1 | [CAS DataBase Reference]
99469-99-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
41 | [Safety Statements ]
26-39 | [RIDADR ]
UN3261 | [WGK Germany ]
WGK 3 | [REACH Registrations]
Active | [HazardClass ]
8 | [HS Code ]
2918992090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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