132-98-9
132-98-9 结构式
基本信息
青霉素 V 钾
青霉素V钾盐
青霉素V钾
PENICILLINE V POTASSIUM SALT
PENICILLIN V
PENICILLIN VK
PENICILLIN V POTASSIUM
PENICILLIN V POTASSIUM SALT
PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT
PHENOXYMETHYLPENICILLIN K+ SALT
PHENOXYMETHYLPENICILLIN POTASSIUM
PHENOXYMETHYL PENICILLIN POTASSIUM SALT
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-6-((ph
abicyclo[3.2.0]heptane-2-carboxylate
antibiocin
apsinvk
arcacil
arcasin
aspinvk
beromycin
beromycin(penicillin)
betapen-vk
物理化学性质
安全数据
常见问题列表
Penicillin V (0.002-8.0 mg/L) inhibits the growth of
Streptococci
, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L.
Penicillin V (0.002-8.0 mg/L) inhibits the growth of
C. difficile
, with a MIC
90
of 8 mg/L.
Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of
Staphylococcus aureus
, with a MIC of 0.016 mg/L.
Penicillin V (0.063-0.25 mg/kg; a single s.c.) inhibits the outgrowth of
S. aureus
in mice thigh muscle.
Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats.
Penicillin V (2 mg/kg; a single s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L•h).
| Animal Model: | Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus |
| Dosage: | 0.063, 0.13, 0.25 mg/kg |
| Administration: | A single s.c. |
| Result: | Decreased the number of CFU (1.34×10 7 counts/mL) compared to controls (3.5×10 7 counts/mL) at the dose of 0.25 mg/kg. |
551-16-6
701-99-5
132-98-9
一般步骤：向冷却至0-5℃并搅拌的2.76 g（12.5 mmol）6-氨基青霉烷酸（6-APA）溶于60 mL水（含5.25 g，62.5 mmol碳酸氢钠）的溶液中，缓慢滴加2.76 g（16.2 mmol）苯氧乙酰氯溶于5 mL丙酮的溶液，滴加时间控制在1分钟内。反应混合物在10-15℃下剧烈搅拌20分钟。反应完成后，用15 mL甲基异丁基酮（MIBK）萃取水相两次，弃去有机相。将水相冷却至5-10℃，用冷的5.0 mol/L硫酸溶液酸化至pH 2.0。酸化后的水相用50 mL MIBK萃取两次，合并有机相，用冷水洗涤，无水硫酸钠干燥10分钟。过滤除去干燥剂，向滤液中加入10 mL 25% 2-乙基己酸钾的丁醇溶液，析出白色结晶。过滤收集固体，用干燥丙酮洗涤，真空干燥，得到3.5 g（产率80%）目标化合物(2S,5R,6R)-3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫杂-1-氮杂二环[3.2.0]庚-2-羧酸钾，为白色固体。熔点：210-211℃（分解）。1H NMR (400 MHz, DMSO-d6): δ 8.42 (d, 1H, J = 8.0 Hz), 7.27 (m, 2H), 6.92 (m, 3H), 5.42 (dd, 1H, J = 8.0, 4.0 Hz), 5.40 (d, 1H, J = 4.0 Hz), 4.62 (d, 2H, J = 2.2 Hz), 3.88 (s, 1H), 1.52 (s, 3H), 1.46 (s, 3H); 13C NMR (100 MHz, DMSO-d6): δ 172.8, 169.0, 168.1, 158.1, 130.0, 121.7, 115.0, 74.6, 67.3, 66.7, 65.0, 57.8, 32.7, 27.8; HRMS (FAB) 计算值 C16H18KN2O5S [M + H]+: m/z 389.0584; 实测值: 389.0995。
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