1722-62-9
中文名称
盐酸甲哌卡因
英文名称
Mepivacaine hydrochloride
CAS
1722-62-9
EINECS 编号
217-023-9
分子式
C15H22N2O
MDL 编号
MFCD00243006
分子量
246.35
MOL 文件
1722-62-9.mol
更新日期
2024/04/17 11:03:23
1722-62-9 结构式
基本信息
中文别名
N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺盐酸盐盐酸甲哌卡因
低分子肝素
盐酸卡波卡因
甲哌卡因盐酸盐
英文别名
1-methyl-2',6'-pipecoloxylidine hydrochloride1-METHYL-2',6'-PIPECOLOXYLIDINE HYDROCHLORIDE SALT
LABOTEST-BB LT00134661
MEPIVACAINE
MEPIVACAINE HCL
MEPIVACAINE HYDROCHLORIDE
n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride
N-(2,6-DIMETHYLPHENYL)-1-METHYL-2-PIPERIDINECARBOXAMIDE HYDROCHLORIDE SALT
(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride
1-methyl-2’,6’-pipecoloxylididehydrochloride
6’-pipecoloxylidide,1-methyl-2monohydrochloride
carbocainehydrochloride
dl-1-methyl-2’,6’-pipecoloxylididehydrochloride
dl-mepivacainehydrochloride
n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride
MEPIVACAINE HYDROCHLORIDE, USP
Mepivacaine HCl USP
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride
2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI)
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI)
所属类别
原料药：局部麻醉剂安全数据
警示词危险
危险性描述H301-H336
危险品标志Xn
危险类别码R22
安全说明S22-S24/25
危险品运输编号UN 2811 6.1 / PGIII
RTECS号TK6475000
海关编码29333990
毒性LD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg)
1722-62-9(安全特性,毒性,储运)
储运特性
库房低温通风干燥毒性分级
中毒急性毒性
腹腔-小鼠 LD50: 117 毫克/公斤; 静脉-小鼠 LD50: 35 毫克/公斤可燃性危险特性
热分解排出有毒氮氧化物烟雾类别
有毒物质灭火剂
水, 二氧化碳, 泡沫, 干粉盐酸甲哌卡因价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-B0517A | 盐酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 500mg | 650元 |
| 2024/01/25 | HY-B0517A | 盐酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 10mM * 1mLin Water | 715元 |
| 2024/01/25 | HY-B0517A | 盐酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 1g | 1023元 |
常见问题列表
生物活性
Mepivacaine 是一种叔胺，用作局部麻醉剂。体外研究
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.
体内研究
对马的测试表明，与根据以前解剖的，乳胶注射后得到的假定相比，mepivacaine在相邻关节结构间具有更大的扩撒，与关节造影研究形成对比。经历膝关节镜检查患者中，与神经刺激相比较，超声处理使1.5% mepivacaine阻断坐骨神经所需的最低有效麻醉剂体积(MEAV50)减少37%。在犬齿和前臼齿中，lidocaine制剂与肾上腺素相比，3%mepivacaine的使用使麻醉时间间隔更短。