24155-42-8
24155-42-8 结构式
基本信息
1-(2,4-二氯苯基)-2-(1-H-咪唑)乙醇
1-(2,4-二氯苯基)-2-(1H-咪唑基)-乙醇
1-[2-羟基-2-(2,4-二氯苯基)乙基]咪唑
α-(2,4-二氯苯基)-1H-咪唑-1-乙醇
咪唑缩合物
2-(2,4-二氯苯基)-1-氢咪唑-1-乙醇
咪唑乙醇
1-(2,4-二氯苯基)-2-(1-咪唑基)乙醇
1-(2,4-二氯苯基)-1H-咪唑基-1-乙醇
1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol
1-(2,4-DICHLOROPHENYL)-2-IMIDAZOL-1-YL ETHANOL
1H-IMIDAZOLE-1-ETHANOL, ALPHA-(2,4-DICHLOROPHENYL)-
ALPHA-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOL
ALPHA-(2,4-DICHLOROPHENYL)-2-1H-IMIDAZOLE-1-ETHANOL
ALPHA-(2,4-DICHLORO PHENYL)-B-(IMIDAZOLE-YL)ETHANOL
-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
2,4-dichloro-alpha-(1-imidazolylmethyl)-benzylalcoho
alpha-(2,4-dichlorophenyl)-imidazole-1-ethano
n-(beta-(2,4-dichlorophenyl)-beta-hydroxyethyl)imidazole
r14821
t824
1-(2,4-Dichlorphenyl)-2-1-Imidazolyl)-Ethanol
1-(2,4-Dichlorophenyl)-2-((1H)-imidazol-1-yl)-ethane
alpha-(2,4-Dichlorophenyl)-1H-
2-(2,4-dichlorobenzene)-imidazole-1-ethanol
ALPHA- (2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-ETHANOL
IMIDAZOLE ETHANOL
Imidazole-1-ethanol alpha-(2,4-dichlorophenyl)
物理化学性质
制备方法
46503-52-0
24155-42-8
以2'-(1H-咪唑-1-基)-2,4-二氯苯乙酮为原料合成alpha-(2,4-二氯苯基)-1H-咪唑-1-乙醇的一般步骤：在配备有搅拌器、温度计和滴液漏斗的1000 mL三颈烧瓶中，加入102 g 2'-(1H-咪唑-1-基)-2,4-二氯苯乙酮（0.4 mol）和300 mL甲醇。分批加入硼氢化钾，缓慢加热至回流。反应完成后，继续搅拌1小时，并通过薄层色谱（TLC）监测反应进程（展开剂为乙酸乙酯：甲醇=10:1，v/v）。反应结束后，减压蒸馏回收甲醇。将浓缩液用5%盐酸溶液调节pH至4-5，随后进行抽滤。滤液用5%碳酸氢钠溶液调节pH至7-8，此时有白色固体析出。抽滤收集固体，用水洗涤，干燥后进行重结晶，得到93.1 g 1-(2,4-二氯苯基)-2-(1H-咪唑-1-基)乙醇，产率为90.5%，熔点为134-135℃。
参考文献：
[1] Patent: CN102180835, 2016, B. Location in patent: Paragraph 0015; 0016
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1665 - 1674
[3] Polyhedron, 2013, vol. 52, p. 106 - 114
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294
[5] Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 162 - 175