77-21-4
中文名称
格鲁米特
英文名称
DL-Glutethimide
CAS
77-21-4
EINECS 编号
201-012-0
分子式
C13H15NO2
MDL 编号
MFCD00056091
分子量
217.26
MOL 文件
77-21-4.mol
77-21-4 结构式
基本信息
中文别名
3-乙基-3-苯基-2,6-哌啶二酮格鲁米特
DEA限制
导眠能
英文别名
2-ethyl-2-phenylglutarimide3-ETHYL-3-PHENYL-2,6-PIPERIDINEDIONE
D,L-GLUTETHIMIDE
GLUTETHIMIDE
RARECHEM AB PP 2824
(R,S)-3-ethyl-3-phenyl-2,6-piperidinedione
2,6-Piperidinedione, 3-ethyl-3-phenyl-
2,6-piperidinedione,3-ethyl-3-phenyl
2-ethyl-2-phenyl-glutarimid
2-Phenyl-2-ethylglutaric acid imide
2-phenyl-2-ethylglutaricacidimide
3-Ethyl-3-phenyl-2,6-diketopiperidine
3-Ethyl-3-phenyl-2,6-dioxopiperidine
3-Phenyl-3-ethyl-2,6-diketopiperidine
3-Phenyl-3-ethyl-2,6-dioxopiperidine
Alfimid
alpha-Ethyl-alpha-phenylglutarimide
alpha-Phenyl-alpha-ethylglutaric acid imide
alpha-phenyl-alpha-ethylglutaricacidimide
alpha-Phenyl-alpha-ethylglutarimide
所属类别
原料药：其它神经系统用药物理化学性质
熔点84°C
沸点357.82°C (rough estimate)
密度1.0960 (rough estimate)
折射率1.5300 (estimate)
闪点9℃
储存条件-20°C
酸度系数(pKa)pKa 11.8 (Uncertain)
水溶解性0.95g/L(27 ºC)
NIST化学物质信息Glutethimide(77-21-4)
安全数据
警示词危险
危险品标志Xn
危险类别码R22
安全说明S36
危险品运输编号3249
WGK Germany1
RTECS号MA4725000
危险等级6.1(b)
包装类别III
海关编码29251200
毒性Glutethimide,
and a structurally similar compound methyprylon, has been used
occasionally as a sedative-hypnotic, although glutethimide’s use
for longer than 3 days is not recommended and it is rarely, if
ever, prescribed today. Glutethimide causes a skin rash in nearly
10% of those using it, and although it was once thought to produce
less respiratory depression than the barbiturates its overdose
fatality record is not good. Much of the drug’s action can
be attributed to 4-hydroxyglutethimide, which is more than twice
as potent and has a long half-life. Like many other sedativehypnotics,
abrupt withdrawal after chronic use or abuse
resembles that of ethanol or the barbiturates and must be managed
accordingly.