89-00-9

外观性状无色柱状结晶。 微溶于水，不溶于苯和醚。

溶解性微溶于水，不溶于苯和醚。

熔点188-190 °C (dec.) (lit.)

熔点188-190 °C (dec.)(lit.)

沸点295.67°C (rough estimate)

密度1.5216 (rough estimate)

折射率1.6280 (estimate)

储存条件Keep in dark place,Sealed in dry,Room Temperature

溶解度10g/l

酸度系数(pKa)2.43(at 25℃)

形态结晶粉末

颜色白色至浅黄米色

气味 (Odor)odorless

水溶解性0.55 g/100 mL

Merck14,8073

检测方法HPLC,NMR

BRN137110

InChIKeyGJAWHXHKYYXBSV-UHFFFAOYSA-N

警示词警告

WGK Germany3

WGK Germany3

RTECS号US7967250

TSCAT

危险等级IRRITANT

海关编码29333999

毒性Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.