Na + , Ca 2+ channel. α4β2δ GABA A receptor.
(+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF.