网站主页 >> CAS数据库列表 >> 4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺
4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺
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- CAS号:
- 1258861-20-9
- 英文名:
- LY2940680
- 英文别名:
- NSC7667;NSC 7667;NSC-7667;LY2940680;Taladegib;LY2940680 USP/EP/BP;LY2940680 (Taladegib);LY 2940680; LY2940680;Taladegib (LY2940680);Taladegib hydrochloride
- 中文名:
- 4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺
- 中文别名:
- 化合物TALADEGIB;LY2940680,刺猬信号通路抑制剂;4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺;4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺(LY2940680)
- CBNumber:
- CB02516035
- 分子式:
- C26H24F4N6O
- 分子量:
- 512.5
- MOL File:
- 1258861-20-9.mol
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4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺化学性质
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沸点:
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703.5±60.0 °C(Predicted)
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密度:
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1.39
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; ≥5.2 mg/mL in EtOH with ultrasonic; ≥51.3 mg/mL in DMSO with gentle warming and ultrasonic
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形态:
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crystalline solid
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酸度系数(pKa):
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7.94±0.30(Predicted)
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颜色:
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White to off-white
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4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺性质、用途与生产工艺
Taladegib (LY2940680)与Smoothened(Smo)受体结合,有效抑制Hedgehog(Hh)信号通路。Phase 1/2。
LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib.
LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch
+/- p53
-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity.
Taladegib (LY2940680)与Smoothened(Smo)受体结合,有效抑制Hedgehog(Hh)信号通路。Phase 1/2。
4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13242 | Taladegib | | 1 mg | 500元 |
2024/08/19 | HY-13242 | 4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺 Taladegib | 1258861-20-9 | 5mg | 1100元 |
4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺
生产厂家
1258861-20-9, 4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 活性分子
- 抑制剂
- 小分子抑制剂
- 小分子抑制剂,天然产物
- 干细胞与Wnt信号
- 信号转导通路激酶抑制剂
- C26H24F4N6O
- LY2940680,刺猬信号通路抑制剂
- 化合物TALADEGIB
- 4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺(LY2940680)
- 4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺
- 1258861-20-9
- LY2940680 Taladegib LY-2940680
- NSC-7667
- NSC7667
- NSC 7667
- LY2940680 USP/EP/BP
- Benzamide, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-
- LY 2940680; LY2940680
- 4-fluoro-N-Methyl-N-[1-[4-(2-Methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-2-(trifluoroMethyl)benzaMide
- 4-fluoro-N-Methyl-N-(1-(4-(1-Methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoroMethyl)benzaMide
- 4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide
- 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluo
- Taladegib hydrochloride
- Taladegib
- LY2940680 (Taladegib)
- LY2940680
- 4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide LY 2940680
- Taladegib (LY2940680)