PI-3065
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- CAS号:
- 955977-50-1
- 英文名:
- PI-3065
- 英文别名:
- PI-306;129556;PI-3065;CS-1274;PI-3065, >=98%;PI-3065|PI3065;PI-3065 USP/EP/BP;4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
- 中文名:
- PI-3065
- 中文别名:
- 化合物CH5132799;PI 3065,PI 3-激酶P110Δ抑制剂;4-(6-((4-(环丙基甲基)哌嗪-1-基)甲基)-2-(5-氟-1H-吲哚-4-基)噻吩并[3,2-D]嘧啶-4-基)吗啉;6-[[4-(环丙基甲基)-1-哌嗪基]甲基]-2-(5-氟-1H-吲哚-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶
- CBNumber:
- CB02705093
- 分子式:
- C27H31FN6OS
- 分子量:
- 506.64
- MOL File:
- 955977-50-1.mol
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PI-3065化学性质
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密度:
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1.372±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
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形态:
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solid
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酸度系数(pKa):
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14.80±0.30(Predicted)
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CAS 数据库:
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955977-50-1
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PI-3065性质、用途与生产工艺
PI-3065是一种选择性p110δ抑制剂，IC50为15 nM,选择性比其他PI3K家族成员高出70多倍。
PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.
In mouse model, PI-3065 (75 mg/kg, p.o.) also suppresses 4T1 tumor growth and metastasis via inactivation of p110δ. In the LSL.Kras
G12D/+; p53
R172H/+; Pdx
Cretg/+ (or KPC) model of pancreatic ductal adenocarcinoma, PI-3065 prolongs survival and reduces the incidence of macroscopic metastases and other disease-associated pathologies.
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p110α
910 nM (IC
50
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p110β
600 nM (IC
50
)
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p110δ
5 nM (IC
50
)
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PI-3065
上下游产品信息
上游原料
下游产品
955977-50-1, PI-3065 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 小分子抑制剂
- 小分子抑制剂，天然产物
- C27H31FN6OS
- PI 3065,PI 3-激酶P110Δ抑制剂
- 化合物CH5132799
- 4-(6-((4-(环丙基甲基)哌嗪-1-基)甲基)-2-(5-氟-1H-吲哚-4-基)噻吩并[3,2-D]嘧啶-4-基)吗啉
- 6-[[4-(环丙基甲基)-1-哌嗪基]甲基]-2-(5-氟-1H-吲哚-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶
- 955977-50-1
- PI-3065 USP/EP/BP
- CS-1274
- Thieno[3,2-d]pyrimidine, 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-
- 129556
- 4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri
- PI-306
- 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
- PI-3065, >=98%
- 6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine PI-3065
- 6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine
- 4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine
- PI-3065|PI3065
- 6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
- PI-3065