ChemicalBook >> CAS DataBase List >>PI-3065
PI-3065
- CAS No.
- 955977-50-1
- Chemical Name:
- PI-3065
- Synonyms
- PI-306;129556;PI-3065;CS-1274;PI-3065, >=98%;PI-3065|PI3065;PI-3065 USP/EP/BP;4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
- CBNumber:
- CB02705093
- Molecular Formula:
- C27H31FN6OS
- Molecular Weight:
- 506.64
- MDL Number:
- MFCD28167771
- MOL File:
- 955977-50-1.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Density | 1.372±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | ≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 14.80±0.30(Predicted) |
| CAS DataBase Reference | 955977-50-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H332 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 | |||||||||
| NFPA 704 |
|
PI-3065 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 5mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 10mg | $274 | 2024-03-01 | Buy |
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 25mg | $553 | 2024-03-01 | Buy |
| Tocris | 5919 | PI3065 ≥98%(HPLC) | 955977-50-1 | 50 | $1045 | 2021-12-16 | Buy |
PI-3065 Chemical Properties,Uses,Production
Biological Activity
pi-3065 is a small molecule and selective inhibitor of p110δkinase with an ki value of 1.5nm and ic50 value of 5nm [1].pi-3065 has been reported to selectively inhibit p110δkinase with ki values of 15nm, 110nm, 130nm and 940nm, ic50 values of 5nm, 91nm, 600nm and >10000nm for p110δ, p110α, p110β and p110γ, respectively. in addition, pi-3065 has been revealed to inhibit 4t1 tumour growth and metastasis. pi-3065 has also noted to prolong survival and reduce the incidence of macroscopic metastases and other disease-associated pathologies [1].
in vitro
PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.
target
| p110α 910 nM (IC 50 ) | p110β 600 nM (IC 50 ) | p110δ 5 nM (IC 50 ) |
storage
Store at -20°C
PI-3065 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 88)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
955977-50-1(PI-3065)Related Search:
PI-3065
6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
PI-3065|PI3065
4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine
6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine
6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine PI-3065
PI-3065, >=98%
6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
PI-306
4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri
129556
Thieno[3,2-d]pyrimidine, 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-
CS-1274
PI-3065 USP/EP/BP
955977-50-1
C27H31FN6OS
Inhibitors