4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
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- CAS号:
- 289656-45-7
- 英文名:
- Senicapoc
- 英文别名:
- Senicapoc;ICA 17043;Senicapoc (ICA17043);ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
- 中文名:
- 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
- 中文别名:
- 塞尼卡泊;SENICAPOC,通道阻断剂;2,2-双(4-氟苯)-2-苯乙酰胺;2,2-双(4-氟苯基)-2-苯乙酰胺;4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺;4-氟-ALPHA-(4-氟苯基)-ALPHA-苯基苯乙酰胺
- CBNumber:
- CB31261049
- 分子式:
- C20H15F2NO
- 分子量:
- 323.34
- MOL File:
- 289656-45-7.mol
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4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺化学性质
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熔点:
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180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
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沸点:
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460.7±45.0 °C(Predicted)
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密度:
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1.250±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
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形态:
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Powder
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酸度系数(pKa):
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15.41±0.50(Predicted)
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颜色:
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White to yellow
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InChI:
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InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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InChIKey:
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SCTZUZTYRMOMKT-UHFFFAOYSA-N
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SMILES:
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C(C1C=CC=CC=1)(C1C=CC(F)=CC=1)(C1C=CC(F)=CC=1)C(=O)N
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4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺性质、用途与生产工艺
Senicapoc (ICA-17043) 是有效,选择性的 Gardos 通道 (Ca2+ 激活的 K+ 通道; KCa3.1) 阻断剂,IC50 为 11 nM。Senicapoc 阻断来自人红细胞的 Ca2+ 诱导的铷通量,IC50 值为 11 nM, 抑制红细胞脱水的 IC50 为 30 nM。
IC50: 11 nM (Gardos channel)
ICA-17043 is shown to block the Gardos channel of mouse (C57 Black) RBCs with an IC
50
of 50±6 nM. ICA-17043 blocks this increase in cellular hemoglobin concentration in human RBCs in a concentration-dependent fashion.
ICA-17043 (10 mg/kg, p.o.) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K
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content without changes in Na
+
content. ICA-17043 (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep.
4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-50694 | Senicapoc | | 5 mg | 594元 |
2024/08/19 | HY-50694 | 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 Senicapoc | 289656-45-7 | 10mg | 865元 |
4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
生产厂家
289656-45-7, 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 相关搜索:
- 合成有机化合物配体
- 膜转运
- 离子通道
- C20H15F2NO
- SENICAPOC,通道阻断剂
- 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
- 2,2-双(4-氟苯)-2-苯乙酰胺
- 塞尼卡泊
- 4-氟-ALPHA-(4-氟苯基)-ALPHA-苯基苯乙酰胺
- 2,2-双(4-氟苯基)-2-苯乙酰胺
- 289656-45-7
- Senicapoc (ICA17043)
- Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-
- ICA-17043;ICA 17043;ICA17043
- Senicapoc
- ICA 17043
- 4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide
- 4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
- Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-
- 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide