KC7F2
| 中文名称 | KC7F2 |
|---|---|
| 中文同义词 | 化合物ML228;ML 228,HIF通路激活剂 |
| 英文名称 | ML-228 |
| 英文同义词 | ML-228;N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine;ML228; ML 228;N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine;CID-46742353;ML-228;CID-46742353;L-228;1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)- |
| CAS号 | 1357171-62-0 |
| 分子式 | C27H21N5 |
| 分子量 | 415.49 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1357171-62-0.mol |
| 结构式 |  |
KC7F2 性质
| 沸点 | 686.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.228±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C, Inert atmosphere |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.03±0.63(Predicted) |
| 颜色 | 淡黄色至浅黄色 |
ML228 (CID-46742353) 是一种有效的 HIF 信号通路激活剂，EC50 为 1 μM。ML228 可激活 HIF 以及下游 EGFR。
EC50: 1 μM (HIF)
ML228 (CID-46742353) represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications.
ML228 (injection; 1 µg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduce SCI secondary injury and promote the recovery of neurological function.
| Animal Model: | SD rat |
| Dosage: | 1 µg/kg |
| Administration: | injection; 7 days |
| Result: | Alleviated SCI of the central nervous system and relieve associated symptoms. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-12754 | ML228 | 1 mg | 450元 | |
| 2024/01/25 | HY-12754 | KC7F2 ML228 | 1357171-62-0 | 5mg | 990元 |