己酮可可碱 化学药品说明书己酮可可碱肠溶片|药典2005版己酮可可碱|药典2005版
PDE
Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner. Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells. Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells. Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase. Pentoxifylline results in high LC3-II/LC3-ratio.
Cell Autophagy Assay
Apoptosis Analysis
Cell Cycle Analysis
Western Blot Analysis
Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and could reduce cognitive impairment.