UNC3230
|
|
|
- CAS号:
- 1031602-63-7
- 英文名:
- UNC3230
- 英文别名:
- UNC3230;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
- 中文名:
- UNC3230
- 中文别名:
- 化合物UNC 3230;UNC 3230,PIP5K1C抑制剂;5-(环己烷甲酰胺基)-2-(苯基氨基)噻唑-4-甲酰胺
- CBNumber:
- CB63067589
- 分子式:
- C17H20N4O2S
- 分子量:
- 344.43
- MOL File:
- 1031602-63-7.mol
|
|
|
UNC3230化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM)-
|
-
形态:
-
A crystalline solid
-
|
UNC3230性质、用途与生产工艺
UNC3230 是一种有效的选择性的,ATP 竞争性的磷脂酰肌醇 4 磷酸 5 激酶 1C 型 (PIP5K1C) 抑制剂，IC50 约为 41 nM。UNC3230 还可抑制 PIP4K2C，但不抑制其他调节磷酸肌醇水平的脂质激酶。UNC3230 具有镇痛和抗癌作用。
IC50: ~41 nM (Phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C))
Membrane PIP2 levels are significantly reduced by ~45% in dorsal root ganglia (DRG) neurons treated with 100 nM UNC3230 (~2-fold above the IC50) relative to vehicle controls. UNC3230 significantly reduces lysophosphatidic acid (LPA)-evoked calcium signaling in cultured DRG neurons relative to vehicle.
UNC3230 (2 nmol) significantly increases noxious heat-evoked paw withdrawal latency for two hours after intrathecal injection in wild-type mice, indicating an antinociceptive effect.
UNC3230 (2 nmol; intrathecal injection) is administered then one hour later co-injected 1 nmol LPA with UNC3230 (2 nmol, intrathecal injection). UNC3230 significantly blunts thermal hyperalgesia and mechanical allodynia compared to vehicle.
UNC3230 (2 nmol; intrathecal injection) significantly blunts thermal hyperalgesia and mechanical allodynia in the complete Freund’s adjuvant (CFA)-inflamed hindpaw (relative to vehicle control) but does not affect thermal or mechanical sensitivity in the control (non-inflamed) hindpaw over a multiday time course.
UNC3230
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-110150 | UNC3230 | | 1 mg | 590元 |
| 2024/01/25 | HY-110150 | UNC3230
UNC3230 | 1031602-63-7 | 5mg | 1300元 |
1031602-63-7, UNC3230 相关搜索:
- 酶
- UNC 3230,PIP5K1C抑制剂
- 化合物UNC 3230
- 5-(环己烷甲酰胺基)-2-(苯基氨基)噻唑-4-甲酰胺
- 1031602-63-7
- hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
- 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide
- 4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-
- 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
- 2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide
- UNC3230