环亮氨酸 MSDSCycloleucine
Ki: 600 μM (NMDA)
Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m 6 A and the penultimate G m in B77 38S RNA subunits by greater than 90%. Cytostatic (10 µg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines.
Cycloleucine (0.5-4 µg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats.