N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
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- CAS号:
- 901-47-3
- 英文名:
- P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL
- 英文别名:
- Tosylarginine Methyl Ester;Nα-Tosyl-L-arginine methyl;Nα-Tosylarginine methyl ester;TOSYL-L-ARGININE METHYL ESTER;Nα-Tosyl-L-arginine methyl ester;N-4-Tosyl-L-arginine methyl ester;Nα-(p-Tolylsulfonyl)-L-arginine methyl ester;Nα-(4-Methylphenylsulfonyl)-L-arginine methyl ester;P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL USP/EP/BP;L-Arginine, N2-[(4-methylphenyl)sulfonyl]-, methyl ester
- 中文名:
- N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
- 中文别名:
- TAME,APC抑制剂;NA-P-甲苯磺基-L-精氨酸甲酯;N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
- CBNumber:
- CB8506528
- 分子式:
- C14H22N4O4S
- 分子量:
- 342.41
- MOL File:
- 901-47-3.mol
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N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯化学性质
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沸点:
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516.5±60.0 °C(Predicted)
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密度:
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1.34
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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≥ 17.1mg/mL in DMSO
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酸度系数(pKa):
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9.06±0.50(Predicted)
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N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯性质、用途与生产工艺
TAME 是后期促进复合体 (APC/C 或 APC) 的抑制剂，它与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化，产生有丝分裂阻滞。
Anaphase-promoting complex (APC)
The absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 auto-ubiquitination in its N-terminal region. Cyclin B1 antagonizes TAME's effect by promoting binding of free Cdc20 to the APC and suppressing Cdc20 auto-ubiquitination.
TAME stabilizes cyclin B1 in
Xenopus
extract by two mechanisms. First, it reduces the k
cat
of the APC
Cdc20
/cyclin B1 complex without affecting the K
m
, slowing the initial ubiquitination of unmodified cyclin B1. Second, as cyclin B1 becomes ubiquitinated, it loses its ability to promote Cdc20 binding to the APC in the presence of TAME. As a result, cyclin B1 ubiquitination terminates before reaching the threshold necessary for proteolysis.
N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
上下游产品信息
上游原料
下游产品
N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
生产厂家
901-47-3, N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯 相关搜索:
- Inhibitors
- 药靶配体
- 细胞周期
- 小分子抑制剂，天然产物
- TAME,APC抑制剂
- NA-P-甲苯磺基-L-精氨酸甲酯
- N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
- 901-47-3
- L-Arginine, N2-[(4-methylphenyl)sulfonyl]-, methyl ester
- N-4-Tosyl-L-arginine methyl ester
- P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL USP/EP/BP
- 5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoic acid methyl ester
- TOSYL-L-ARGININE METHYL ESTER
- (S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate
- Nα-Tosyl-L-arginine methyl ester
- Nα-Tosyl-L-arginine methyl
- Nα-Tosylarginine methyl ester
- Nα-(p-Tolylsulfonyl)-L-arginine methyl ester
- Nα-(4-Methylphenylsulfonyl)-L-arginine methyl ester
- Tosylarginine Methyl Ester