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Bimatoprost Produkt Beschreibung

Bimatoprost Struktur
155206-00-1
CAS-Nr.
155206-00-1
Englisch Name:
Bimatoprost
Synonyma:
Bima;CS-2897;LUMIGAN;BiMapnost;Prostamide;BIMATOPROST;BIMATOPROST(TM);Bimatoprost API;buprostaglandin;cGMP Bimatoprost
CBNumber:
CB0171421
Summenformel:
C25H37NO4
Molgewicht:
415.57
MOL-Datei:
155206-00-1.mol

Bimatoprost Eigenschaften

Schmelzpunkt:
66-68°C
Siedepunkt:
629.8±55.0 °C(Predicted)
Dichte
1.145±0.06 g/cm3(Predicted)
storage temp. 
−20°C
pka
14.25±0.20(Predicted)
Aggregatzustand
solid
InChIKey
AQOKCDNYWBIDND-FTOWTWDKSA-N
CAS Datenbank
155206-00-1(CAS DataBase Reference)

Sicherheit

WGK Germany  3

Bimatoprost Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.

Chemische Eigenschaften

Crystalline Solid

Originator

Allergan (US)

Verwenden

Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2a.

Verwenden

Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2α.

Verwenden

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha

Verwenden

Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.

Verwenden

17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.[Cayman Chemical]

Trademarks

Lumigan (Allergan).

Allgemeine Beschreibung

Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.

Bimatoprost Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bimatoprost Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 316)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shanghai finete Pharmaceutical Co., Ltd.
+86-18221039705
- sales@finetechpharm.com CHINA 139 55
-
18292830413 029-86107037-8014
sales7@konochemical.com CHINA 2999 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3252 55
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales01@yibaibiotech.com CHINA 420 58
Honestpharm Co., Ltd
+86-15318812076
sale@jnhonestpharm.com; honestpharm@163.com; CHINA 280 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 537 55

155206-00-1()Verwandte Suche:


  • Beme Prostaglandin
  • Bima
  • Bimatoprost (W.S)
  • bimatoprost powder
  • CS-2897
  • N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE
  • LUMIGAN
  • BIMATOPROST
  • BIMATOPROST(TM)
  • 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ETHYL AMIDE
  • BIMATOPROST(LUMIGAN)
  • 17-phenyl-tri-norprostaglandin f2α-ethyl amide
  • (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide
  • Prostamide
  • 17-phenyl-tri-norprostaglandin f2α-ethyl a
  • cGMP Bimatoprost
  • BiMapnost
  • BiMatoprost HOUSE STANDARD
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enaMide
  • 17-Phenyl-tri-norprostaglandin F2a-ethyl aMide
  • (Z)-7-((1R,2R,3S,5S)-3,5-dihydroxy-2-((E)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethylhept-5-enamide
  • Bimatoprost, >=99.5%
  • Bimatoprost API
  • (Z)-7-((1R,2R,3S,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethyl
  • Bimatoprost CAS NO.155206-00-1
  • buprostaglandin
  • 155206-00-1
  • 206-00-1
  • Prostaglandins
  • Prostaglandin
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Arachidonic Acid Cascade
  • Lipids in Cell Signaling
  • Lumigan
  • Inhibitors
  • Benzotriazoles ,Others ,Benzoxazines
  • pharmaceutical intermediate
  • API
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