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Budesonid Produkt Beschreibung

CAS-Nr.51333-22-3
Bezeichnung:Budesonid
Englisch Name:Budesonide
Synonyma:
BIDIEN;S-1320;Budeson;Entocort;Micronyl;Respules;Barazone;PREFERID;SPIROCORT;PULMICORT
CBNumber:CB0313122
Summenformel:C25H34O6
Molgewicht:430.53
MOL-Datei:51333-22-3.mol
Budesonid physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 221-232°C (dec.)
Siedepunkt:: 464.79°C (rough estimate)
alpha : D25 +98.9° (c = 0.28 in methylene chloride)
Dichte: 1.1046 (rough estimate)
Brechungsindex: 1.4593 (estimate)
storage temp. : Store at RT
Löslichkeit: Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
Aggregatzustand: powder
Merck : 14,1468
InChIKey: VOVIALXJUBGFJZ-KWVAZRHASA-N
CAS Datenbank: 51333-22-3(CAS DataBase Reference)
Sicherheit
Kennzeichnung gefährlicher: Xn
R-Sätze:: 40-36/37/38-20/21/22
S-Sätze:: 22-36-26
WGK Germany : 3
RTECS-Nr.: TU3723000
HS Code : 29372900

Budesonid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White Solid
Verwenden
A non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent
Verwenden
Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor with an EC50 value of 12.4 nM. Like other glucocorticoids, budesonide reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease. Also like other glucocorticoids, budesonide may be abused by athletes.[Cayman Chemical]
Verwenden
laxative, antineoplastic
Verwenden
The oral capsule is used for the treatment of mild to moderate active Crohn's disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatme
Definition
ChEBI: A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.
Trademarks
Entocort (AstraZeneca); Pulmicort (AstraZeneca); Rhinocort (AstraZeneca).
Allgemeine Beschreibung
Budesonide (Pulmicort Turbohaler,Rhinocort) is extensively metabolized in the liver, with 85%to 95% of the orally absorbed drug metabolized by the firstpasseffect. The major metabolites are 6β-hydroxybudesonideand 16α-hydroxyprednisolone, both with less than1% of the activity of the parent compound. Metabolism involvesthe CYP3A4 enzyme, so coadministration of budesonidewith a known CYP3A4 inhibitor should be monitoredcarefully.
Allgemeine Beschreibung
Budesonide, 16α,17-[butylidenebis-(oxy)]-11β,21-dihydroxypregna-1,4-diene-3, 20-dione (Entocort), in oral capsules is used to treat Crohn disease. Theaffinity for the GC is approximately 200-fold greater than thatof hydrocortisone and 15-fold greater than that of prednisolone.Budesonide is a mixture of epimers, with the 22Rform having twice the affinity for the GR of the S epimer.This GC is metabolized by CYP3A4, and its levels can be increasedin the presence of potent CYP3A4 inhibitors.Budesonide is also used in an inhaled formulation for thetreatment of asthma.
Biologische Aktivität
Synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.
Budesonid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Budesonid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 248)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153sales@crovellbio.com CHINA 407 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688bruce@xrdchem.cn CHINA 541 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 956 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409orders@qcchemical.com United States 8409 58
 
51333-22-3(Budesonid)Verwandte Suche:
Betamethason Desonid (S)-16α,17-(Butylidendioxy)-11β,21-dihydroxypregna-1,4-dien-3,20-dion 16α(R),17-[Butylidenbis(oxy)]-11β,21-dihydroxypregna-1,4-dien-3,20-dion Budesonid 1,4-Dioxan Selendioxid DIOXOPROMETHAZINE HCL DIOXOPROMETHAZINE
BIDIEN BUDESONIDE CORTIVENT ENTOCORT CR 1,4-PREGNADIEN-(R, S)-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE CYCLIC 16,17 ACETAL 16,17-BUTYLIDENEBIS[OXY]-11,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE (11-beta,16-alpha)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-dien 16-alpha)-et PULMICORT SPIROCORT S-1320 RHINOCORT 16alpha(R),17-[butylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione Budesonide EP Budsonide S-1320, Bidien, Cortivent, Entocort CR, Preferid, Pulmicort, rhinocort, Spirocort, Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11.beta.,16.alpha.)- BUDESONIDE,MICRONIZED BUDESONIDE,MICRONIZED,EP 16α,17α-Butylidenedioxy-11β,21-dihydroxypregna-1,4-dien-3,20-dione 16α,17α-(Butylidenedioxy)-11β,21-dihydroxypregna-1,4-diene-3,20-dione 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv. Entocort Micronyl Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, (11β,16α)- Pulmicort Turbuhaler Respules Rhinocort Aqua Cell Biology Cell Signaling and Neuroscience BioChemical 51333-22-3 1950-4-4 Immune Cell Signaling and Blood 16a, 17a - Butylidenedioxy - 11, 21 - dihydroxy - 1, 4 - pregnadiene - 3, 20 - dione] Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, (11b,16a)- 11β,21-Dihydroxy-16α,17-(butylidenebisoxy)pregna-1,4-diene-3,20-dione 11β,21-Dihydroxy-16α,17-(butylidenedioxy)pregna-1,4-diene-3,20-dione S-budesonide (11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione Budesonide,16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione 17-alpha-butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-16-alph 4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-pregna-(11-b Budeson NebuaMpul Budesonide controlled-release Barazone Budecort Aqua Pregna-1,4-diene-3,20-dione, 16,17-[(1R)-butylidenebis(oxy)]-11,21-dihydroxy-, (11β,16α)- Budesonide solution,100ppm Budesonide, >=99% PREFERID Budesonide (200 mg)F0E3020.997mg/mg(ai) Budesonide (200 mg) Budesonide Dispensing forM: 0,25 Mg/Ml 20 unit dos Budenofalk BudesoMide Mixture of the C-22S (epimer A) and the C-22R (epimer B) epimers of 16α,17-[(1RS)-butylidenebis(oxy)]-11β,21-dihydroxypregna-1,4-diene-3,20-dione
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