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5-Nitro-2-furfurolsemicarbazon Produkt Beschreibung

Nitrofurazone Struktur
59-87-0
CAS-Nr.
59-87-0
Bezeichnung:
5-Nitro-2-furfurolsemicarbazon
Englisch Name:
Nitrofurazone
Synonyma:
NF;NFZ;NFS;NF-7;Nefco;acutol;Amifur;Chixin;Mammex;U-6421
CBNumber:
CB0492724
Summenformel:
C6H6N4O4
Molgewicht:
198.14
MOL-Datei:
59-87-0.mol

5-Nitro-2-furfurolsemicarbazon Eigenschaften

Schmelzpunkt:
242-244 °C(lit.)
Siedepunkt:
335.43°C (rough estimate)
Dichte
1.6031 (rough estimate)
Brechungsindex
1.6500 (estimate)
Flammpunkt:
2 °C
storage temp. 
2-8°C
Löslichkeit
Very slightly soluble in water, slightly soluble in ethanol (96 per cent).
Aggregatzustand
neat
pka
pKa 9.28± 0.03( EtOH,t =35±0.1,I=0.00) (Uncertain)
Wasserlöslichkeit
<0.1 g/100 mL at 19 ºC
Sensitive 
Light Sensitive
Merck 
14,6600
BRN 
86403
InChIKey
IAIWVQXQOWNYOU-FPYGCLRLSA-N
CAS Datenbank
59-87-0(CAS DataBase Reference)
NIST chemische Informationen
5-Nitro furfural semicarbazone(59-87-0)
EPA chemische Informationen
Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]- (59-87-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,F
R-Sätze: 22-36-20/21/22-11
S-Sätze: 36-36/37-26-16
RIDADR  3249
WGK Germany  3
RTECS-Nr. LT7700000
8
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29321900
Giftige Stoffe Daten 59-87-0(Hazardous Substances Data)
Toxizität LD50 in rats (g/kg): 0.59 orally; 3.0 s.c. (Godwin)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H341 Kann vermutlich genetische Defekte verursachen. Keimzellmutagenität Kategorie 2 Warnung P201,P202, P281, P308+P313, P405,P501
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

5-Nitro-2-furfurolsemicarbazon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

white to light yellow crystal powde

Verwenden

Anti-infective (topical). Antimicrobial.

Definition

ChEBI: A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcer , wounds and skin infections.

Definition

A type of organic compound containing the C:N.NH.CO.NH2 grouping, formed by reaction of an aldehyde or ketone with semicarbazide (H2N.NH.CO.NH2). The compounds are crystalline solids with sharp melting points, which can be used to characterize the original aldehyde or ketone.

Trademarks

Actin-N (Sherwood); Furacin (Shire);Acmor-s;Akutol;Anginofur;Auroid;Beca furazona;Bifuran;Burnazone;Dermobion;Ectofural;Escofuran;Escofuron;Fluorobioptal;Furacilinum;Furacinas;Furacinethin;Furacin-sol;Furacin-streusol;Furacocid;Furacol;Furaseptin;Fura-septin;Fura-vet;Furea;Furesan;Furotalgin;Furovol;Germax;Germex;Ginejuvent;I fomula;Ii formula;Kamfomen;Kindrog;Lifuzol;Mammiject;Mastidol;Muldacin;Neovagon;Nfz 1;Nitocetin;Nitrocol plus;Nitro-rea;Notaba;Sanifur;Scandantin;Sulfamyton-n;Taristop;Tranoxa;Tuocurine;Urafadyn;Uroletten;Viropulver;Yalrocin;Zoppin spray blu.

Weltgesundheitsorganisation (WHO)

Nitrofural, a nitrofuran derivative with broad-spectrum antibacterial activity, was introduced in the early 1940s for the topical treatment of various skin conditions. It has also been used systemically for the treatment of African trypasonomiasis. Following recent findings of in vitro mutagenicity and of carcinogenicity in experimental animals, use of topical preparations containing this substance was restricted in Germany. Nitrofural remains registered in several countries and the World Health Organization is not aware of restrictive action having been taken elsewhere.

Allgemeine Beschreibung

Odorless pale yellow needles or yellow powder. pH (saturated aqueous solution) 6.0 - 6.5. Alkaline solutions are dark orange.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

Furacilin darkens on prolonged exposure to light. Furacilin can react violently with reducing materials. .

Brandgefahr

Flash point data for Furacilin are not available; however, Furacilin is probably combustible.

Pharmazeutische Anwendungen

A synthetic compound used in the topical treatment of wounds and burns and as an instillation for bladder washout. A nitrofurazone-impregnated urinary catheter is said to reduce infection in catheterized patients. Activity against the common bacterial pathogens is sufficient to cover most pathogens that cause infections of burns and wounds, with the important exception of Ps. aeruginosa. Attention has been drawn to its activity against methicillin-resistant Staphylococcus aureus, and its use in clearing carriage has been suggested. Slight absorption occurs from intact skin (c. 1%) and burned skin (5%). It is neither a primary irritant nor a sensitizer, but some preparations contain polyethylene glycol as a vehicle, and absorption can cause problems in patients with reduced renal function. Of limited availability.

Kontakt-Allergie

Nitrofurazone is an antibacterial agent used in animal feeds. Occupational dermatitis was reported in cattle breeders or farmers.

Clinical Use

5-Nitro-2-furaldehyde semicarbazone (Furacin) occurs asa lemon-yellow crystalline solid that is sparingly solublein water and practically insoluble in organic solvents.Nitrofurazone is chemically stable, but moderately lightsensitive.It is used topically in the treatment of burns, especiallywhen bacterial resistance to other agents may be a concern.It may also be used to prevent bacterial infection associatedwith skin grafts. Nitrofurazone has a broad spectrumof activity against Gram-positive and Gram-negative bacteria,but it is not active against fungi. It is bactericidalagainst most bacteria commonly causing surface infections,including S. aureus, Streptococcus spp., E. coli,Clostridium perfringens, Enterobacter (Aerobacter) aerogenes,and Proteus spp.; however, P. aeruginosa strainsare resistant.Nitrofurazone is marketed in solutions, ointments, andsuppositories in a usual concentration of 0.2%.

Sicherheitsprofil

Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Questionable carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data, Experimental reproductive effects. A human sensitizer. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Nitrofurazone can be used topically as an antibacterial for treating or preventing superficial infections. It is a nitrofuran antibacterial that is bactericidal for many bacteria, including E. Coli, Staph aureus, etc. Nitrofurazone’s mechanism of action is thought to be associated with inhibiting bacterial enzymes that primarily degrade glucose and pyruvate.

5-Nitro-2-furfurolsemicarbazon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5-Nitro-2-furfurolsemicarbazon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 201)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3202 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21753 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
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+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
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+86-025-86736275
dana.jiang@royal-chem.com CHINA 488 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1849 55
Yancheng Green Chemicals Co.,Ltd
86-515-87883661
86-515-87883652 sales@greenchem-china.com CHINA 348 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58

59-87-0(5-Nitro-2-furfurolsemicarbazon)Verwandte Suche:


  • NFZ
  • NITROFURAL
  • NITROFURAZONE
  • (5-Nitro-2-furfurylidenamino)urea
  • (5-Nitro-2-furfurylideneamino)urea
  • 1-(5-Nitro-2-furfurylidene)semicarbazide
  • 1-(5-Nitrofurfurylidene)semicarbazide
  • 2-((5-nitro-2-furanyl)methylene)-hydrazinecarboxamid
  • 5-nitrofuran-2-aldehydesemicarbazone
  • 5-Nitrofurazone
  • 6-Nitrofuraldehyde semicarbazide
  • 6-nitrofuraldehydesemicarbazide
  • Actin-N
  • acutol
  • Aldomycin
  • Alfucin
  • Amifur
  • Babrocid
  • Becafurazone
  • Biofuracina
  • Biofurea
  • Chemofuran
  • Chixin
  • Cocafurin
  • component of Furacort
  • component of Furadex
  • component of Furea
  • Coxistat
  • Dermofural
  • Dymazone
  • Dynazone
  • Eldezol
  • Eldezol F-6
  • eldezolf-6
  • 5-NITRO-2-FURALDEHYDE SEMICARBAZONE
  • AKOS B004247
  • 2-[(5-nitro-2-furanyl)methylene]-hydrazinecarboxamide
  • LABOTEST-BB LT00134617
  • FURACILIN
  • FURACIN
  • Nitrofurazon
  • FURACILIN[2-((5-NITRO-2-FURANYL)METHYLENE)-HYDRAZINECARBOXAMIDE]
  • semicarbazone
  • 5-NITRO-2-FURFURYLIDENE SEMICARBAZONE, BP 98+%
  • 5-Nitro-2-furaldehyde semicarbazone, 98+%
  • Nitrofurazone solution
  • 5-Nitro-2-furfural semicarbazone, Furacin, NFZ, Nitrofurazone
  • Nitrofurazone (200 mg)
  • Nitrofurazone198.14
  • 5-Nitro-2-furaldehyde semicarbazone(Nitrofurazone)
  • Nitrofurazone(Nitrofural)
  • furacillin Nitrofurazone
  • 2-[(5-nitro-2-furanyl)methylene]-hydrazinecarboxamid
  • 2-Furaldehyde, 5-nitro-, semicarbazone
  • 2-Furancarboxaldehyde, 5-nitro-, semicarbazone
  • 5-Nitro-2-furaldehyde semicarbazole
  • 5-nitro-2-furaldehydsemicarbazone
  • 5-Nitro-2-furancarboxaldehyde semicarbazone
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