Entecavir
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- CAS-Nr.
- 142217-69-4
- Englisch Name:
- Entecavir
- Synonyma:
- Etv;Baraclude;entikawei;2-amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one;CS-863;CS-1236;Entecavi;SQ 34676;Enticavir;ENTECAVIR
- CBNumber:
- CB0506719
- Summenformel:
- C12H15N5O3
- Molgewicht:
- 277.28
- MOL-Datei:
- 142217-69-4.mol
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Entecavir Eigenschaften
- Schmelzpunkt:
- 249-252°C
- Siedepunkt:
- 661.4±65.0 °C(Predicted)
- Dichte
- 1.81±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Sparingly)
- pka
- 14.22±0.60(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivität
- [α]/D +25 to +40°, c = 0.2 in H2O
- Stabilität:
- Hygroscopic
- CAS Datenbank
- 142217-69-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H320 |
Causes eye irritation |
Serious eye damage/eye irritation |
Category 2B |
Warnung |
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P264, P305+P351+P338,P337+P313 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
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Entecavir Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Entecavir is a cyclopentyl guanosine analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection, and it is the third nucleoside or nucleotide analog to be marketed for this indication. Lamivudine, a deoxythiacytosine analog, and adefovir dipivoxil, a nucleotide analog, have been marketed since 1998 and 2002, respectively. Entecavir and adefovir are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections.
Chemische Eigenschaften
White to Off-White/Yellow Crystalline Powder
Definition
ChEBI: Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus
Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it ha
no activity against HIV. It is used for the treatment of chronic hepatitis B.
Handelsname
Baraclude (BMS)
Clinical Use
Treatment of chronic hepatitis B virus infection in patients >16 years of age.
Entecavir comes as a tablet and solution (liquid) to take by mouth. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Take entecavir at around the same time every day.
Entecavir Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Entecavir Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 502)Lieferanten
142217-69-4()Verwandte Suche:
- Aids098045
- Aids-098045
- Enticavir
- EntikaweiPian
- 2-Amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-3H-purin-6(9H)-one ,99.7%
- (1S,3R,4S)-9-[4-Hydroxy-3-(hydroxyMethyl)-2-Methylenecyclopentyl]guanine
- Entecavir Anhydrous
- 20MG/100MG/100G
- Entecavir Tablets
- Entecavir (as hydrate)
- Entecavir,99%e.e.
- Entecavi
- ENTECAVIR, 98-102%
- entecavir Baraclude
- 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one, Baraclude
- ENTECAVIR
- 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
- 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one
- SQ 34676
- 6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]
- Entecavir USP Impurity B
- 2-amino-9-[(1R,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-3H-purin-6-one hydrate
- CS-863
- CS-1236
- Entecavir, BMS200475
- Entecavir（SQ 34676
- Entecavir/Entecavir Monohydrate
- Entecavir USP/EP/BP
- 2-Amino-9-(4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl)-3,9-dihydro-purin-6-one
- Etv
- 2-amino-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one
- Baraclude
- entikawei
- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylene-cyclopentyl]-1H-purin-6-one
- 142217-69-4
- 209216-23-6
- 12477-69-4
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