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Aminocapronsure Produkt Beschreibung

6-Aminocaproic acid Struktur
60-32-2
CAS-Nr.
60-32-2
Bezeichnung:
Aminocapronsure
Englisch Name:
6-Aminocaproic acid
Synonyma:
ACS;EACS;EACA;177jd;cy116;Hepin;Amikar;Amicar;CY 116;177 J.D
CBNumber:
CB5223888
Summenformel:
C6H13NO2
Molgewicht:
131.17
MOL-Datei:
60-32-2.mol

Aminocapronsure Eigenschaften

Schmelzpunkt:
207-209 °C (dec.) (lit.)
Siedepunkt:
242.49°C (rough estimate)
Dichte
1.042 g/cm3
Dampfdruck
<0.1 hPa (20 °C)
Brechungsindex
1.4870 (estimate)
Flammpunkt:
207-209°C
storage temp. 
Store below +30°C.
Löslichkeit
H2O: 50 mg/mL
Aggregatzustand
powder
pka
4.373(at 25℃)
Farbe
white
PH
7.0-7.5 (50g/l, H2O, 20℃)
Geruch (Odor)
Odorless
Wasserlöslichkeit
SOLUBLE
Merck 
14,432
BRN 
906872
InChIKey
SLXKOJJOQWFEFD-UHFFFAOYSA-N
CAS Datenbank
60-32-2(CAS DataBase Reference)
NIST chemische Informationen
Hexanoic acid, 6-amino-(60-32-2)
EPA chemische Informationen
Hexanoic acid, 6-amino- (60-32-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36
WGK Germany  2
RTECS-Nr. MO6300000
TSCA  Yes
HS Code  29224995
Giftige Stoffe Daten 60-32-2(Hazardous Substances Data)
Toxizität LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warnung P264, P305+P351+P338,P337+P313
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Aminocapronsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

white crystalline powder

Originator

Epsilon,Roche,W. Germany,1962

Verwenden

hemostatic

Verwenden

6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.

Verwenden

Propylparaben Food preservative

Verwenden

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Definition

ChEBI: An amino-acid anion that is the conjugate base of 6-aminohexanoic acid.

Manufacturing Process

5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired.

Trademarks

Amicar (Xanodyne).

Therapeutic Function

Antifibrinolytic

Mechanism of action

Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.

Sicherheitsprofil

Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.

Chemical Synthesis

Aminocaproic acid (24.4.1) is synthesized by hydrolyzing ε -caprolactam at high temperature.

Veterinary Drugs and Treatments

Aminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.

Aminocapronsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Aminocapronsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 492)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Yancheng Green Chemicals Co.,Ltd
86-25-86655873
86-25-52279193 sales@greenchem-china.com CHINA 89 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 536 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58

60-32-2(Aminocapronsure)Verwandte Suche:


  • 177 J.D
  • 177 J.D.
  • 177j.d.
  • 177jd
  • 6-amino-hexanoicaci
  • Acepramin
  • Acepramine
  • ACS
  • Afibrin
  • Amicar
  • Amikar
  • Aminokapron
  • Atsemin
  • Caplamin
  • Capracid
  • capralense
  • Capramol
  • Capranol
  • Caprocid
  • Caprolisin
  • CL 10304
  • cl10304
  • CY 116
  • cy116
  • eacakabi
  • EACS
  • e-aminocaproicacid
  • Epsamon
  • Epsicapron
  • Epsikapron
  • Epsilcapramin
  • epsilon S
  • epsilon-Amino-n-hexanoic acid
  • EPSILON-AMINO HEXANOIC ACID
  • EPSILON-AMINO-N-CAPROIC ACID
  • EPSILON-AMINOCAPROIC ACID
  • H-E-ACP-OH
  • H-EPSILON-ACP-OH
  • H-EPSILON-AHX-OH
  • H-EPSILON-AMINOCAPROIC ACID
  • H-AHX(6)-OH
  • H-6-AHX-OH
  • H-ACP(6)-OH
  • H-ACP-OH
  • EACA
  • NH2-(CH2)5-COOH
  • OMEGA-AMINOCAPROIC ACID
  • ETA-AMINOCAPROIC ACID
  • 6-AMINOCAPROIC ACID SIGMAULTRA
  • 6-Aminohexanoic acid 1 M Solution
  • 6-AminocaproicAcid,>99%
  • H-6-Aca-OH~epsilon-Aminocaproic acid~6-Aminohexanoic acid~EACA
  • H-EAhx-OH
  • 6-Amino-n-caproic acid;6-Aminohexanoic acid
  • aminocaproic acid,EACA
  • 6-AMinocaproic acid, 99+% 500GR
  • Aminocaproic
  • AMinocaproic-d6 Acidd6
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