Isonicotinonitril

4-Cyanopyridine Struktur
100-48-1
CAS-Nr.
100-48-1
Bezeichnung:
Isonicotinonitril
Englisch Name:
4-Cyanopyridine
Synonyma:
ISONICOTINONITRILE;4-PYRIDINECARBONITRILE;Pyridine-4-carbonitrile;4-cyanopyridin;4-CYANOPYRIDINE;Cyanopyridine,4-;4-Pyridinenitrile;AKOS BBS-00004486;Isonicotinonitril;TIMTEC-BB SBB008923
CBNumber:
CB0688145
Summenformel:
C6H4N2
Molgewicht:
104.11
MOL-Datei:
100-48-1.mol

Isonicotinonitril Eigenschaften

Schmelzpunkt:
76-79 °C(lit.)
Siedepunkt:
196 °C
Dichte
1.1145 (rough estimate)
Dampfdruck
41.9Pa at 25℃
Brechungsindex
1.5242 (estimate)
Flammpunkt:
88 °C
storage temp. 
Sealed in dry,Room Temperature
Löslichkeit
40g/l
Aggregatzustand
Crystals or Powder
pka
pK1:1.90(+1) (25°C)
Farbe
White to off-white
Wasserlöslichkeit
3.2 g/100ml (16.4 ºC)
BRN 
107712
Expositionsgrenzwerte
NIOSH: IDLH 25 mg/m3
Stabilität:
Stable. Incompatible with strong bases, strong oxidizing agents, strong acids.
InChIKey
GPHQHTOMRSGBNZ-UHFFFAOYSA-N
LogP
0.46 at 25℃
CAS Datenbank
100-48-1(CAS DataBase Reference)
NIST chemische Informationen
4-Pyridinecarbonitrile(100-48-1)
EPA chemische Informationen
4-Pyridinecarbonitrile (100-48-1)

Sicherheit

Kennzeichnung gefährlicher Xn
R-Sätze: 20/21/22
S-Sätze: 36/37-24/25
RIDADR  3276
WGK Germany  3
TSCA  Yes
PackingGroup  III
HS Code  29333999

Isonicotinonitril Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

beige solid

Verwenden

4-Cyanopyridine is used as an intermediate in organic synthesis and pharmaceutical substances like isonicotinylhydrazide, which is used in the treatment of tuberculosis. It is used as a precursor for the preparation of isonicotinic acid and 4-diemthylaminopyridine (DMAP). It is involved in the synthesis of 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine by reacting with acetonitrile.

Synthese

4-Cyanopyridine is synthesised by the reaction of 4-methylpyridine with ammonia and air in the presence of a catalyst. The specific synthesis steps are as follows:
4-Methylpyridine and ammonia vaporisation preheating to 180-330°C, then into the mixing tank and air mixing uniformly, into the fixed-bed reactor by the top of the fixed-bed reactor after the distribution of the catalyst-filled reactor, the control of the reaction temperature in the range of 330-450 ° C, the reaction head pressure is controlled in the range of 0.020-0.070 KPa, the reaction temperature is controlled by molten salts, the reaction gas after the end of the reaction After the reaction, the reaction gas was condensed to sub-zero fractionation to obtain the crude product of 4-cyanopyridine, and the crude product was distilled to obtain the finished product of 4-cyanopyridine. The conversion rate of 4-methylpyridine was above 99%, and the yield of 4-cyanopyridine was above 98%.
4-Cyanopyridine synthesis

mögliche Exposition

Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.

Versand/Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Inkompatibilitäten

Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .

Isonicotinonitril Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Isonicotinonitril Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 568)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
LEAPCHEM CO., LTD.
+86-852-30606658
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Junwee Chemical co., Ltd.
+86-571-85808636 +86-13958122542
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Hebei Mojin Biotechnology Co., Ltd
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career henan chemical co
+86-0371-86658258
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Biochempartner
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Shenzhen Nexconn Pharmatechs Ltd
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admin@nexconn.com China 7838 58

100-48-1(Isonicotinonitril)Verwandte Suche:


  • ISONICOTINIC ACID NITRILE
  • AKOS BBS-00004486
  • 4-CYANOPYRIDINE
  • 4-Pyridinecarbonitrile 98%
  • 4-cyanopyridine (4-CP)
  • TIMTEC-BB SBB008923
  • SPECS AC-907/25014099
  • gamma-Cyanopyridine
  • 4-Pyridinenitrile
  • Cyanopyridine,4-
  • 4-cyanopyridin
  • Isonicotinic cid nitrile
  • 4-Cyanopyridine ,99%
  • 4-Pyridinecarbonitrile,4-Cyanopyridine, Isonicotinic acid nitrile, Isonicotinonitrile
  • 4-Pyridinecarbonitri
  • 4-Cyanopyridine, 98% 100GR
  • 4-Cyanopyridine, 98% 500GR
  • 4-Cyanopyridine, 98% 5GR
  • 4-Cyanopyridine, Isonicotinic acid nitrile, Isonicotinonitrile
  • 4-Cyanopyridine,98%
  • 4-PYRIDINECARBONITRILE FOR SYNTHESIS
  • Topiroxostat impurity B(Isoniazid Impurity 5)
  • Topiroxostat Impurity 2 ( Isoniazid Impurity 5 )
  • 4-Cyanopyridine/4-Pyridinenitrile
  • Fampridine Impurity 2 (4-Cyanopyridine)
  • 4-Cyanopyridine >
  • Fampridine Impurity 2
  • Ethionamide EP Impurity B
  • Fampridine Impurity 9(4-Cyanopyridine)
  • Isonicotinonitril
  • 4-Cyanopyridine ISO 9001:2015 REACH
  • Ethionamide Impurity 2 (Ethionamide EP Impurity B)
  • ISONICOTINONITRILE
  • 4-PYRIDINECARBONITRILE
  • Pyridine-4-carbonitrile
  • 2-Methyl-104-nitrobenzyl&chloride
  • Isoniazid EP Impurity C
  • Isoniazid EP Impurity C(Topiroxostat Impurity B)
  • 100-48-1
  • 83880-65-9
  • C5H3NCN
  • C6H4N
  • Pyridines
  • Heterocyclic Building Blocks
  • Building Blocks
  • C6
  • Heterocycle-Pyridine series
  • cyanide
  • Pyridines derivates
  • bc0001
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