Zileuton
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- CAS-Nr.
- 111406-87-2
- Englisch Name:
- Zileuton
- Synonyma:
- ZYFLO;Zyfl;Leutml;ABT-077;Leutrol; A-64077;ZILEUTON;CGS-23622;Griluto-CR;AKOS 91253
- CBNumber:
- CB1344903
- Summenformel:
- C11H12N2O2S
- Molgewicht:
- 236.29
- MOL-Datei:
- 111406-87-2.mol
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Zileuton Eigenschaften
- Schmelzpunkt:
- 157-158°C
- Siedepunkt:
- 449.4±47.0 °C(Predicted)
- Dichte
- 1.401±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- DMSO: ≥20mg/mL at ~60°C (warm up to 60 C for 5min)
- pka
- pKa 10.3(H2O
t undefined
I undefined) (Uncertain)
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- CAS Datenbank
- 111406-87-2(CAS DataBase Reference)
Zileuton Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC
50 value of 0.5 μM. Zileuton inhibits leukotriene B
4 (LTB
4; ) production induced by the calcium ionophore A23187 in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC
50 = 0.6 μM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge. Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.
Chemische Eigenschaften
Crystalline Solid
Definition
ChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT
, and LTE4. It is used for the management of chronic asthma.
Biologische Aktivität
Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB 4 synthesis (IC 50 values are 0.56, 2.3 and 2.6 μ M in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC 50 = 6 μ M) and exhibits antiasthmatic activity in vivo . Also weakly inhibits CYP1A2 (K i = 66 - 98 μ M).
Zileuton Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Zileuton Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 347)Lieferanten
111406-87-2()Verwandte Suche:
- Zileuton and its intermediates
- A-64077
- Abbott 64077
- Leutrol
- Zyfl
- 1-(1-(BENZO[B]THIOPHEN-2-YL)ETHYL)-1-HYDROXYUREA
- Leutml
- N-(1-Benzolb]thien-2-ylethyl)。N-hydroxyurea
- 1-[1-(1-Benzothiophen-2-yl)ethyl]-1-hydroxyurea
- 1-Hydroxy-1-[1-(benzo[b]thiophene-2-yl)ethyl]urea
- ABT-077
- CGS-23622
- Zileuton (150 mg)
- ZYFLO (zileuton)
- 1-[(1S)-1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
- N-(1-bezo[b]thien-2-yl-ethyl)-N-hydroxy-urea
- Griluto-CR
- Zileuton
1-(1-Benzothiophen-2-ylethyl)-1-hydroxy-urea
- Zileuton, >=99%
- Zileuton (Zilpaterol)
- ZILEUTON
- AKOS 91253
- 1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea
- Qi Liu Tong
- High quality USP 39/EP 9.0 /BP 2012 GMP DMF FDA Zileuton producer
- Zileuton USP/EP/BP
- Zileuton (A 64077
- ZileutonQ: What is
Zileuton Q: What is the CAS Number of
Zileuton Q: What is the storage condition of
Zileuton Q: What are the applications of
Zileuton
- "Zileuton-13C2,15N"
- Zileuton (1724656)
- ZYFLO
- 111406-87-2
- 11406-87-2
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- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Amines
- Aromatics
- Active Pharmaceutical Ingredients
- Antiasthmatic
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