W-7 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Calmodulin is a calcium-
dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-
7 is a cell-
permeable antagonist of calmodulin (K
i = 11 μM). Two molecules of W-
7 bind to calcium-
binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-
7 also associates, at lower affinities, with calcium-
binding domains of other proteins, including troponin C and myosin light chain kinase (K
i = 70 and 300 μM, respectively).
Chemische Eigenschaften
White Crystalline Solid
Verwenden
W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.
Allgemeine Beschreibung
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC
50 = 51 μM) and Ca
2+-calmodulin-dependent phosphodiesterase (IC
50 = 28 μM).
Biologische Aktivität
Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).
W-7 HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
