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Pregabalin Produkt Beschreibung

Pregabalin Struktur
148553-50-8
CAS-Nr.
148553-50-8
Englisch Name:
Pregabalin
Synonyma:
Lyrica;Pregablin;PREGABALIN;(R)-Pregabalin;(S)-Pregabalin;xiangxizhiliao;Pregabalin solution;LYRICA (pregabalin);3(S)-(AMINOMETHYL)-5;Pregabalin powder 99%
CBNumber:
CB2251105
Summenformel:
C8H17NO2
Molgewicht:
159.23
MOL-Datei:
148553-50-8.mol

Pregabalin Eigenschaften

Schmelzpunkt:
194-196°C
alpha 
D23 +10.52° (c = 1.06 in water)
Flammpunkt:
9℃
storage temp. 
Store at RT
Löslichkeit
deionized water: ≥10mg/mL
Aggregatzustand
white powder
InChIKey
AYXYPKUFHZROOJ-ZETCQYMHSA-N
CAS Datenbank
148553-50-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,T,F
R-Sätze: 63-48/22-39/23/24/25-23/24/25-11
S-Sätze: 22-36/37-45-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
HS Code  29224999
Giftige Stoffe Daten 148553-50-8(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H318 Verursacht schwere Augenschäden. Schwere Augenschädigung Kategorie 1 Achtung P280, P305+P351+P338, P310
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Pregabalin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

As a follow-up to its g-aminobutyric acid (GABA) agonist gabapentin, Pfizer has developed and launched pregabalin for the treatment of epilepsy and neuropathic pain. Although pregabalin is a structural analog of GABA, it does not interact with GABA-A or GABA-B receptors or influence GABA uptake. The exact mechanism of action is unclear, but pregabalin may reduce excitatory neurotransmitter release by binding to the α2-δ protein subunit of voltage-gated calcium channels. The resulting inhibition of excess neuronal activity is believed to be the basis for pregabalin’s efficacy in epilepsy and neuropathic pain alleviation. Since the activity is attributed to the (S′)-enantiomer alone, an efficient asymmetric synthesis is employed for commercial production. The key step is the asymmetric hydrogenation of 3-cyano-5-methyl-3-hexenoic acid using a chiral rhodium catalyst to afford an intermediate that is enriched in the (S′)-enantiomer. The cyano group is ultimately reduced by routine hydrogenation with a nickel catalyst. Further enrichment of the final product is realized by selective recrystallization with (S′)-mandelic acid or simply recrystallizing from water/isopropanol. Compared to gabapentin, pregabalin is 2- to 10-fold more potent in various animal models. For example, in preventing maximal electroshock seizures (MES) in mice, pregabalin has an ED50 of 20 mg/kg p.o. versus 87 mg/kg for gabapentin. A comparable increase in potency is also observed in the rat MES model (ED50=1.8mg=kg p.o. for pregabalin versus 10.3 mg/kg for gabapentin). In addition, pregabalin’s linear pharmacokinetics (Cmax relates to dose) translates to better predictability of pharmacological effects. It has 90% oral bioavailability, with an elimination half-life of approximately 6 h. The primary route of excretion is via the renal system with negligible metabolism. Furthermore, its lack of activity at the cytochrome P450 enzymes was reflected in an absence of pharmacokinetic drug-drug interactions in relevant studies. In a placebocontrolled, fixed dose (up to 600mg/day) trial with pregabalin as an adjunctive therapy for epilepsy, 14 to 51% of patients showed at least a 50% decrease in seizure frequency with a clear dose-response relationship. In a flexible dosing group, (150 mg/day to 600 mg/day), the seizure reduction rate was 35.4%compared to 40.3% for a fixed dose of 600mg/day and 10.6% for placebo. The most common side effects were dizziness (29%) and somnolence (21%). In addition, weight gain (equal to or more than 7% increase from baseline) occurred in 40% of patients in the 12-week study; however, there was no affect on male fertility or efficacy of oral contraceptives in women. Regarding the use of pregabalin in treating painful diabetic peripheral neuropathy, oral administration of 300 and 600 mg/day t.i.d. was superior to placebo (39–48% compared to 15–18% with placebo) in relieving pain and improving pain-related sleep interference. While pregabalin was originally developed as an anticonvulsant for epilepsy, its success in treating neuropathic pain has led to its exploration in treating other CNS disorders, such as, anxiety, social phobia, and fibromyalgia.

Chemische Eigenschaften

Off-White Solid

Originator

Warner-Lambert (US)

Verwenden

S-Enantiomer of Pregabalin. A GABA analogue used as an anticonvulsant. Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.

Verwenden

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade nam

Trademarks

Lyrica (CP).

Pregabalin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pregabalin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 403)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 913 58
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2997 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 699 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 115 55
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 272 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55

148553-50-8()Verwandte Suche:


  • Pregabalin cas148553-50-8(whatsapp:+8618830163278)
  • Pregabalin Manufacturer
  • Pregabalin powder 99%
  • Pregabalin SynonyMs 3-(AMinoMethyl)-5-Methyl-hexanoic acid
  • Pregabalin 3-(Aminomethyl)-5-methyl-hexanoic acid
  • Pregabalin solution
  • Hexanoic acid, 3-(aminomethyl)-5-methyl-, (3S)-
  • Pregabalin and Intermediates
  • Pregabaline ada@tuskwei.com whatsapp
  • 优质 血球蛋白粉 厂家直销 血球蛋白粉 是具有血制品特殊气味的暗红或类红色的均匀粉末,无腐败变质异味,不得含有植物性物质。 血球蛋白粉的特点是: 1. 高蛋白质,高赖氨酸,高缬氨酸。 它经国家权威机构抽样检测显示,血球蛋白粉粗蛋白质含量高达88%以上,其中赖氨酸和缬氨酸分别高达7.4%和7.5%,丰富的 必需氨基酸对母猪泌乳性能有很大的促进作用。 2. 丰富的优质有机铁。 富含250
  • (S)-3-(Aminomethyl)-5-methylhexanoic acid (Pregabalin)
  • 3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
  • (3S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
  • PREGABALIN
  • Pregablin
  • 3-(Aminomethyl)-5-methyl-hexanoic acid
  • PREDNISOLONESODIUMPHOSPHATE
  • (R)-Pregabalin
  • (S)-Pregabalin
  • (S)-3-(Ammoniomethyl)-5-methylhexanoate
  • Lyrica
  • 3(S)-(AMINOMETHYL)-5
  • LYRICA (pregabalin)
  • Pregabalin-13C3 RaceMic
  • PREGABALINE (S)-(+)-3-AMinoMethyl-5-Methylhexanoic acid
  • (S)-(+)-Pregabalin-d4
  • xiangxizhiliao
  • Pregabalin (S)-(+)-3-AMinoMethyl-5-Methylhexanoic acid
  • (S)-Pregabalin (1.0 Mg/ML in Methanol)
  • 148553-50-8
  • 201-483-2
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  • Pregabaline ada@tuskwei.com whatsapp
  • 8618031153937
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  • Neurochemicals
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  • Pfizer compounds
  • LYRICA
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