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Roquinimex

Roquinimex Struktur
84088-42-6
CAS-Nr.
84088-42-6
Englisch Name:
Roquinimex
Synonyma:
FCF89;LS-2616;CS-1231;LINOMIDE;ABR212616;ROQUINIMEX;PNU 212616;Roquinimex(Linomide);N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
CBNumber:
CB2391777
Summenformel:
C18H16N2O3
Molgewicht:
308.33
MOL-Datei:
84088-42-6.mol
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Roquinimex Eigenschaften

Schmelzpunkt:
200-204°
Siedepunkt:
436.2±45.0 °C(Predicted)
Dichte
1.357±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
Löslichkeit
DMSO: 11 mg/mL
pka
4.50±1.00(Predicted)
Aggregatzustand
solid
Merck 
14,8259
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
S-Sätze: 36/37
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  2933.49.2600
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P330 Mund ausspülen.

Roquinimex Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.

Verwenden

Biological response modifier; immunomodulator.

Biologische Aktivität

Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo .

Roquinimex Upstream-Materialien And Downstream Produkte

Upstream-Materialien

3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo- methyl 3-(N-methyl-N-phenylamino)-3-oxopropanoate 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester 1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER 1-Methyl-2H-3,1-benzoxazin-2,4(1H)-dion 4H-3,1-Benzoxazin-2,4(1H)-dion N-Methyl-anilin Anthranilic acid

Downstream Produkte

Roquinimex Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 108)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49390 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24738 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131981 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69
TCI (Shanghai) Development Co., Ltd. 021-67121386
Sales-CN@TCIchemicals.com China 24539 81

84088-42-6()Verwandte Suche:

Dimethyl sebacate N,N-Dimethylformamid Dimethylcarbonat Dimethylphthalat Ethan 2,6-Dimethyloct-7-en-2-ol Dimethylsulfoxid Dimethyl ether Dimethylfumarat
  • N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE
  • ROQUINIMEX
  • LINOMIDE
  • LS-2616
  • 1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE
  • 1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE
  • 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
  • 1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
  • N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide
  • PNU 212616
  • N-phenyl-N-Methyl-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-quinoline-3-carboxaMide
  • CS-1231
  • Roquinimex(Linomide)
  • ABR212616
  • FCF89
  • 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-
  • Tumor Necrosis Factor Receptor,FCF-89,TNF Receptor,TNFR,Roquinimex,Inhibitor,ABR-212616,ABR 212616,FCF 89,inhibit
  • 84088-42-6
  • C18H16N2O3
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Immune System Regulation
  • Immunomodulators and Antibiotics
  • Immune Cell Signaling and Blood
  • Antitumour
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