BISINDOLYLMALEIMIDE I HYDROCHLORIDE

176504-36-2

CAS-Nr.: 176504-36-2

Englisch Name:: BISINDOLYLMALEIMIDE I HYDROCHLORIDE

Synonyma:: BIS-I HCl;GO-6860 HCl;BIM 1 hydrochloride;GF 109203X hydrochloride >=95%;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride

CBNumber:: CB2972282

Summenformel:: C25H25ClN4O2

Molgewicht:: 448.95

MOL-Datei:: 176504-36-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 26

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Eigenschaften

storage temp.: 2-8°C

Löslichkeit: DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL

Aggregatzustand: Orange-red solid

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

WGK Germany	3
HS Code	2933998090

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501

Sicherheit

P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310	BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (K_i = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC₅₀ = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC₅₀ = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT₃ with a K_i value of 61 nM.

Verwenden

GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.

Allgemeine Beschreibung

GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 26)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	991	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9440	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3915	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58

176504-36-2()Verwandte Suche:

[1S-[1α,4aα,5α,7α(E),7aα]]-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[(allyl-1-oxo-3-phenyl)oxy]cyclopenta[c]pyran-1-yl-β-D-glucopyranosid 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-benzopyryliumchlorid Lup-20(29)-en-3-ol, (3β)- (2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron 4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion

BIM 1 hydrochloride
3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
BisindolylMaleiMide I( Hydrochloride Salt)
BisindolylMaleiMide I . hydrochloride [GF-109203K
3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem
GF 109203X hydrochloride >=95%
BIS-I HCl
GO-6860 HCl
176504-36-2