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ChemicalBook > Produktkatalog >Aktive pharmazeutische Wirkstoffe (APIs) >Antipyretische Analgetika >Nicht-steroidale Entzündungshemmer (NSAIDS) >4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion

4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Produkt Beschreibung

CAS-Nr.50-33-9
Bezeichnung:4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion
Englisch Name:Phenylbutazone
Synonyma:
PBZ;Bute;Butoz;Buzon;Kadol;Reudo;Uzone;Azdid;Busone;Butone
CBNumber:CB0370134
Summenformel:C19H20N2O2
Molgewicht:308.37
MOL-Datei:50-33-9.mol
4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 104-107 °C
Siedepunkt:: 448.76°C (rough estimate)
Dichte: 1.1591 (rough estimate)
Brechungsindex: 1.6140 (estimate)
storage temp. : -20°C Freezer
Löslichkeit: Practically insoluble in water, sparingly soluble in alcohol. It dissolves in alkaline solutions.
Aggregatzustand: Powder
pka: 4.5(at 25℃)
Farbe: White to almost white
Wasserlöslichkeit: <0.1 g/100 mL at 23.5 ºC
Merck : 14,7277
BRN : 290080
Stabilität:: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey: VYMDGNCVAMGZFE-UHFFFAOYSA-N
CAS Datenbank: 50-33-9(CAS DataBase Reference)
NIST chemische Informationen: Phenylbutazone(50-33-9)
EPA chemische Informationen: 3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-(50-33-9)
Sicherheit
Kennzeichnung gefährlicher: Xn,T,F
R-Sätze:: 36/37/38-20/21/22-42/43-45-36-11
S-Sätze:: 36/37/39-26-45-22-53-36/37-16
RIDADR : 3249
WGK Germany : 3
RTECS-Nr.: UQ8225000
TSCA : Yes
HazardClass : 6.1(b)
PackingGroup : III
HS Code : 29331990
Giftige Stoffe Daten: 50-33-9(Hazardous Substances Data)

4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R45:Kann Krebs erzeugen.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
Chemische Eigenschaften
Off-Whtie Solid
Verwenden
For the treatment of backache and ankylosing spondylitis
Verwenden
An inhibitor of Cox.
Verwenden
Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively.
Verwenden
A non-steroidal anti-inflammatory compound. An inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase
Trademarks
Azolid (Sanofi Aventis); Butazolidin (Novartis);Algesin;Algirreudin;Algoverine;Alka butazolidin;Alkabutazone;Alka-phenylbutazone;Alka-sterazolidin;Anarthral;Apophenylbutazone;Apo-phenylbutazone;Arteopan;Arthirikin;Artibrin;Artrisin;Artrodesmol extra;Bizolin 20;Bizolin 700;Butacal;Butacol;Butadilat;Butadin;Butadyne;Butafenil;Butagros;Butakvertin;Butaparin;Butaphen;Buta-phen;Butarex;Butartiril;Butatril;Butazolidin alka;Butazolidina;Butial;Butinol;Butiwas;Buto beta;Butoroid cream;Butrex;Carudol;Celestalgon;Celestazone;Colfezone;Corbuvit;Dartranol;Debutazon;Delta-butazolidin;Delta-demoplas;Delta-myogit;Delta-tomanol;Deltawaukobuzon;Dephimixn;Dexa tomanol;Dexa-attritin;Dexa-escopyrin;Dexamed;Dexatrzona;Dibuzon;Direstop;Ditrone;Doctofril;Dolosin dexa;Dolpirina;Ectobutazone;Ethibute;Exraheudon;Exrheudon;F 650;Fenibutina;Flebosil;Glycyl;Hepabuzon;Inflazone;Intrabuzone;Mammyl;Megazone;Mepha-butazone;Mepropyrin;Mi 540;Naupax;Neuro-demoplas;Neuzoline m;Novobutazone;Oluprin;Oppazoen;Osadrinim;Parazolidin;Parzolidon;Pasirheuman;Penetradol;Phenbuff;Phenbutazone;Phenylarthrite;Phenylbetazone;Phenylon plus;Phlebolan;Pirabutil;Pirarreumol-b;Pirarreumol-p;Prebutex;Precirhemin;Prednirheumin;Proxyfezone;Proydynam;Pyrbutal;Ranocor;Reopin;Reumilene;Rheopyrin;Rheosolon;Rheumanoln;Rheumaphen;Rheumycalm;Salzone;Servizolidin;Sigma-elmedal;Sintobutina;Stabilat;Tevocodyn;Tibutazone;Ticinil calcio;Ticinil calico;Trabit;Zolapelin;Zolidinium.
Weltgesundheitsorganisation (WHO)
Phenylbutazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1949 for the treatment of rheumatic disorders. Its use was subsequently associated with serious and sometimes fatal adverse reactions, notably cases of aplastic anaemia and agranulocytosis. Many national drug regulatory authorities consider that more recently introduced drugs offer a safer alternative for most, if not all, patients requiring anti-inflammatory agents. Phenylbutazone has thus been either withdrawn at the national level or retained with rigorously restricted indications for patients unresponsive to other therapy. These restrictions also apply, in general, to combination products containing phenylbutazone.
Allgemeine Beschreibung
Odorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2.
Air & Water Reaktionen
Phenylbutazone is relatively stable at ambient temperatures. Aqueous decomposition of Phenylbutazone occurs by hydrolysis and oxidation. Insoluble in water.
Reaktivität anzeigen
Phenylbutazone is incompatible with strong oxidizers, strong acids and strong bases. .
Brandgefahr
Flash point data for Phenylbutazone are not available; however, Phenylbutazone is probably combustible.
Sicherheitsprofil
Suspected human carcinogen producing leukemia. A human poison by parenteral route. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion and possibly other routes: fever, blood pressure increase, other unspecified vascular effects, damage to kidney tubules and glomeruli, decreased urine volume, blood in the urine, reduction in the number of whte blood cells, and agranulocytosis. Experimental teratogenic and reproductive effects. Human mutation data reported. An eye irritant. An antiinflammatory agent. When heated to decomposition it emits toxic fumes of NOx
läuterung methode
Crystallise the dione from EtOH. Its pK2 3 is 4.52 (in H2O), 4.89 (in 50% aqueous EtOH) and 5.25 (80% 2-methoxyethanol). It complexes with Hg2+, Cd2+ and Zn2+. It has UV with max at 239.5nm in MeOH+50% aqueous HClO4 and 264nm in aqueous 0.1N NaOH. [Beilstein 24 III/IV 1123.]
4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Natriumsulfit Hydrazobenzol Diethylbutylmalonat Natriumethanolat Natriummethanolat 4-Butyl-1,2-diphenylpyrazolidin-3,5-dion, Natriumsalz Diethylmalonat 1-Butanol
Downstream Produkte
4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 251)Lieferanten     
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Shenzhen Sendi Biotechnology Co.Ltd.
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50-33-9(4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion)Verwandte Suche:
Suxibuzon Tribuzon Proxifezon 4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion Zolpidem tartrate Zolpidem 1,2-Diphenyl-4-(2-(phenylsulfi-nyl)ethyl)-3,5-pyrazolidindion tert-Butylchlordiphenylsilan Pyraclostrobine Phenylaceton 4-Butyl-1,2-diphenylpyrazolidin-3,5-dion, Natriumsalz Butyloleat Biphenyl Laurocapram Buprofezin Dibutylphthalat Cyhalofop-butyl 3-Methyl-1-phenyl-5-pyrazolon
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