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Avasimibe

Avasimibe Struktur
166518-60-1
CAS-Nr.
166518-60-1
Englisch Name:
Avasimibe
Synonyma:
CS-90;CI-1011;avasimibe;PD 148515;Ava Maibu;Avasimibe, >=98%;Avasimibe(CI-1011);Avasimibe USP/EP/BP;Avasimibe Solution, 100ppm;AVASIMIBE;CI-1011; PD 148515
CBNumber:
CB3854950
Summenformel:
C29H43NO4S
Molgewicht:
501.72
MOL-Datei:
166518-60-1.mol
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Avasimibe Eigenschaften

Schmelzpunkt:
178-180° (Lee); mp 169.5-170.4° (Dozeman)
Dichte
1.072±0.06 g/cm3(Predicted)
storage temp. 
room temp
Löslichkeit
DMSO: ≥40mg/mL
Aggregatzustand
powder
pka
1.97±0.70(Predicted)
Farbe
white to tan
InChIKey
PTQXTEKSNBVPQJ-UHFFFAOYSA-N

Sicherheit

WGK Germany  3
HS Code  2935909099

Avasimibe Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Avasimibe is a selective inhibitor of Cholesterol Acyltransferase 1 and CYP2C9. Avasimibe is known to induce apoptosis of glioma cell lines as a model of glioblastoma.

Biochem/physiol Actions

Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. It was originally developed as an antilepic drug, and was shown to significantly reduce plasma total triglyceride and VLDL-cholesterol, but later clinical trials were disappointing. ACAT has also been investigated as a potential therapeutic target for Alzheimer′s disease. Recent studies have looked at the effects of avasimibe in reducing amyloid pathology by limiting generation and increasing clearance of diffusible amyloid-beta (Abeta).

Avasimibe Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Avasimibe Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 126)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806
 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 967 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28180 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63711 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018
ramyan@ex-biotech.com CHINA 954 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29220 58

166518-60-1()Verwandte Suche:

3-Chlorpropyltrimethoxysilan N,N-Dimethylacetamid Paracetamol Sulfuryldichlorid Thioacetamid 3-(Triethoxysilyl)-propylamin Acetamid 2-Cyanacetamid Trimethoxyphenylsilan Diethylnitrosamin (1-Methylethyl)benzol ar-Isopropylphenylacetaldehyd
  • Avasimibe, >=98%
  • 2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)acetylsulfamate
  • [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid
  • PD 148515
  • avasimibe
  • n-(2,6-dipropan-2-ylphenoxy)sulfonyl-2-(2,4,6-tripropan-2-ylphenyl)acetamide
  • N-[(2,6-DIISOPROPYLPHENOXY)SULFONYL]-2-(2,4,6-TRIISOPROPYLPHENYL)ACETAMIDE
  • ((2,4,6-TRIS(1-METHYLETHYL)PHENYL)ACETYL)SULFAMICACID2,6-BIS(1-METHYLETHYL)PHENYLESTER
  • Avasimibe(CI-1011)
  • CI-1011
  • AVASIMIBE;CI-1011; PD 148515
  • Sulfamic acid,N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenylester
  • 1-[(2,6-DIISOPROPYLPHENOXYSULFONYL)AMINO]-2-(2,4,6-TRIISOPROPYLPHENYL)ETHANONE
  • Ava Maibu
  • CS-90
  • Avasimibe Solution, 100ppm
  • Avasimibe USP/EP/BP
  • 1-({[2,6-bis(propan-2-yl)phenoxy]sulfonyl}amino)-2-[2,4,6-tris(propan-2-yl)phenyl]ethan-1-one
  • 166518-60-1
  • C29H43NO4S
  • Inhibitors
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