ChemicalBook Deutsch Chinese English Japanese Korea
ChemicalBook > Produktkatalog >Aktive pharmazeutische Wirkstoffe (APIs) >Spezialarzneimittel >Antidote >Acetamid

Acetamid Produkt Beschreibung

CAS-Nr.60-35-5
Bezeichnung:Acetamid
Englisch Name:Acetamide
Synonyma:
CH3CONH2;AMIDE C2;Acetamid;Actamide;ACETAMIDE;NCI-C02108;ETHANAMIDE;acetylamine;Acetylamide;Acetamide,99%
CBNumber:CB3453432
Summenformel:C2H5NO
Molgewicht:59.07
MOL-Datei:60-35-5.mol
Acetamid physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 78-80 °C(lit.)
Siedepunkt:: 221 °C(lit.)
Dichte: 1.159
Dampfdruck: 1 mm Hg ( 65 °C)
Brechungsindex: 1.4274
Flammpunkt:: 220-222°C
storage temp. : Store at RT
Löslichkeit: H2O: 0.5 g/mL, Hazen ≤50
pka: 0.63(at 25℃)
Aggregatzustand: Crystals
Farbe: White
Wasserlöslichkeit: 2000 g/L (20 ºC)
Merck : 14,43
JECFA Number: 1592
BRN : 1071207
Stabilität:: Stable. Incompatible with strong acids, strong oxidizing agents, strong bases. Deliquescent. Triboluminescent.
InChIKey: DLFVBJFMPXGRIB-UHFFFAOYSA-N
CAS Datenbank: 60-35-5(CAS DataBase Reference)
NIST chemische Informationen: Acetamide(60-35-5)
EPA chemische Informationen: Acetamide(60-35-5)
Sicherheit
Kennzeichnung gefährlicher: Xn
R-Sätze:: 40
S-Sätze:: 36/37
RIDADR : UN 3077 9/PG 3
WGK Germany : 1
RTECS-Nr.: AB4025000
F : 3
TSCA : Yes
HS Code : 29241900
Giftige Stoffe Daten: 60-35-5(Hazardous Substances Data)
Toxizität: LD50 orally in Rabbit: 7000 mg/kg

Acetamid Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE, ZERFLIESSENDE KRISTALLE.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Rauche mit Stickstoffoxiden. Reagiert mit Säuren und starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK: Krebserzeugend Kategorie 3B; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols.
INHALATIONSGEFAHREN
Verdampfen bei 20°C vernachlässigbar; eine belästigende Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden, vor allem als Pulver.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen und die Haut.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Möglicherweise krebserzeugend für den Menschen.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Aussehen Eigenschaften
C2H5NO; Essigsäureamid. Farblose Kristalle, praktisch ohne Geruch.
Gefahren für Mensch und Umwelt
Irreversibler Schaden möglich.
LD50 (oral, Ratte): 7000 mg/kg
Schutzmaßnahmen und Verhaltensregeln
Geeignete Schutzhandschuhe als kurzzeitiger Staubschutz.
Verhalten im Gefahrfall
Trocken aufnehmen. Mit Wasser nachreinigen.
Kohlendioxid, Wasser, Pulver.
Brennbar. Im Brandfall können nitrose Gase entstehen.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Viel Wasser trinken lassen. Erbrechen auslösen. Sofort Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag

Sachgerechte Entsorgung
Als feste Laborchemikalienabfälle.
Beschreibung
Acetamide (MEA or ethanamide),  the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot.
Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings.
ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
Chemische Eigenschaften
Acetamide occurs as hexagonal, colorless deliquescent crystals with a musty odor. It is incompatible with strong acids, strong oxidizing agents, strong bases, and tribolumi- nescent. Acetamide is used primarily as a solvent, as a plasticizer, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastics and chemical industries.
Chemische Eigenschaften
Acetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.
Chemische Eigenschaften
White to pale yellow crystalline powder; mousy aroma
Chemische Eigenschaften
Acetamide occurs as hexagonal colourless deliquescent crystals with a musty odour. It is incompatible with strong acids, strong oxidising agents, strong bases, and triboluminescent materials. Acetamide is used primarily as a solvent, a plasticiser, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastic and chemical industries.
Verwenden
  1. Acetamide is often used as plasticizer and as industrial solvent.
  2. molten acetamide is an excellent solvent for many organic and inorganic compounds.
  3. Solubilizer.
  4. renders sparingly soluble substances more soluble in water by mere addition or by fusion.
  5. stabilizer.
  6. manufacture of methylamine, denaturing alcohol.
  7. In organic syntheses.
  8. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent.
  9. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.
Allgemeine Beschreibung
Colorless crystals with a mousy odor (NTP, 1999). Low toxicity.
Air & Water Reaktionen
Deliquescent. Very soluble in water.
Reaktivität anzeigen
Acetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).
Health Hazard
After oral exposures to acetamide, animals developed liver tumors. However, no informa- tion is available on the carcinogenic effects of acetamide in humans. The US EPA has not classifi ed acetamide for carcinogenicity. The IARC has classifi ed acetamide as a Group 2B, meaning a possible human carcinogen.
Health Hazard
Mild irritant; acute oral toxicity in animals very low; oral LD50 value (rats):7000 mg/kg; carcinogenic to animals; oraladministration caused blood and liver tumorsin mice and rats; carcinogenicity: animal limited evidence, no evidence in humans.
Brandgefahr
The flash point of Acetamide has not been determined, but Acetamide is probably combustible.
Sicherheitsprofil
Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by intraperitoneal and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also AMIDES. When heated to decomposition it emits toxic fumes of NOx,.
mögliche Exposition
Used as a stabilizer, plasticizer, wetting agent; solvent in plastics, lacquers, explosive; soldering flux ingredient; and chemical manufacturing
Enzyminhibitor
This simple amide (FW = 59.07 g/mol; CAS 142-26-7; M.P. = 81°C; B.P. = 222° C), Deliquescent solid; Solubility: 97 g/100 mL H2O). Target (s) : thermopsin; b-N-acetylglucosaminidase; urease, weakly inhibited ; alcohol dehydrogenase, weakly inhibited; carbonic anhydrase ; acetylcholinesterase, weakly inhibited; Na+/K+-exchanging ATPase, weakly inhibited; urea carboxylase; amidase, also alternative substrate; pyroglutamyl-peptidase I; soluble epoxide hydrolase, Ki = 37 mM; glucan 1,3-b-glucosidase; and b-N- acetylhexosaminidase.
Erste Hilfe
If this chemical gets into the eyes, remove any contact lenses at once, and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. If this chemical has been inhaled, remove from exposure and transfer promptly to a medical facility.
Lager
Acetamide should be kept stored in a tightly closed container, in a cool, dry, ventilated area. It should be protected against physical damage, away from any source of heat, ignition, or oxidizing materials.
Versand/Shipping
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
läuterung methode
Acetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]
Inkompatibilitäten
Reacts with strong acids, such as hydrochloric, sulfuric, and nitric, strong oxidizers; strong bases; strong reducing agents such as hydrides; ammoniaisocyanates, phenols, cresols. Contact with water causes slow hydrolyzation to ammonia and acetate salts.
Waste disposal
Add to alcohol or benzene as a flammable solvent and incinerate; oxides of nitrogen produced may be scrubbed out with alkaline solution. All federal, state, and local environmental regulations must be observed.
Vorsichtsmaßnahmen
During handling and/use of acetamide, workers should wear special protective equipment. After leaving work areas, workers should wash hands, face, forearms, and neck, dispose of outer clothing, and change to clean garments at the end of the day.
Acetamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Phenylaceton 1,4-Dioxan Ethylphenylacetat Ammoniumacetat Diammoniumcarbonat Ammoniak, wasserfrei
Downstream Produkte
3-Aminopyridin-2-carbonsure Benorilat 2,4-Dimethylthiazol Ethylfluoracetat 1-Phenyl-3-(1,2,3-thiadiazol-5-yl)harnstoff 2,4,5-Trimethylthiazol N-Acetylsulfanilylchlorid Benzol-1,2:4,5-tetracarboxydiimid 5-Amino-1H-imidazol-4-carboxamidmonohydrochlorid Hexannitril 2-Cyan-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamid Trimethylsilyl-N-trimethylsilyl-acetamidat Triethylorthoacetat Dacarbazin Thioacetamid 2-Methylthiazol Gonadotropin, chorionisch 2-Aminoacetamid
Acetamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 263)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153sales@crovellbio.com CHINA 407 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796ivan@atkchemical.com CHINA 24196 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
 
60-35-5(Acetamid)Verwandte Suche:
Ethylcyanacetat Thiamphenicol 4'-Aminoacetanilid Chloramphenicol Diethylacetamidomalonat 2,2-Dibrom-2-cyanacetamid Thioacetamid Paracetamol N-(2-Fluorphenyl)acetamid 4'-Chloracetoacetanilid Colchicin 2,4'-Dichlor-2'-o-chlorbenzoylacetanilid 4'-Bromacetanilid N,N-Dimethylacetamid 2-Chloracetamid 2-Cyanacetamid
Acetylamide acetylamine Amid kyseliny octove amidkyselinyoctove CH3CONH2 Essigsαureamid ethanamide[qr] Methanecarboxamide methanecarboxamide[qr] NCI-C02108 AcetaMide 0.25 Acetamide sublimed, 99% ACETAMIDE >= 99.0% (GC) Acetamide≥ 99% (Assay) AMIDE C2 LABOTEST-BB LT00795814 ETHANAMIDE Acetamid Acetamid(trigonaleForm) acetamide(ethanamide) aceticacidamide[qr] acetimidicacid acetimidicacid[qr] nci-c02108[qr] Amide C2 AMMONIOM-ACETATE Acetamide;Acetic acid;Acetic acid amine;Ethanamide Acetic acid amine ACETAMIDE ACETIC ACID AMIDE 60-35-5 Building Blocks Amides Carbonyl Compounds CH3COONH2 ACETAMIDE, 98+% ACETAMIDE, PCR REAGENT ACETAMIDE, SUBLIMED, ZONE-REFINED, 99% ACETAMIDE GR 99% ACETAMIDE HPLC 99+% ACETAMIDEGC STANDARD ACETAMIDE MOLECULAR BIOLOGY REAGENT AcetamideForSynthesis Acetamide,99% Acetamide, extra pure, 99+% Acetamide, pure, 99% ACETAMIDE REAGENT ACETAMIDE,CRYSTAL,REAGENT Actamide Acetamide/Ethyl cyanoacetate ACETAMIDE extrapure AR Acetamide, 99%, pure 1-Hydroxyethanimine 1-Iminoethanol Acetamide,99+%,extra pure Acetamide,Amide C2 Acetamide, extra pure Acetamide, Zone Refined (number of passes:37)
Urheberrecht 2017 © ChemicalBook. Alle Rechte vorbehalten.