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N,N-Dimethylacetamid Produkt Beschreibung

N,N-Dimethylacetamide Struktur
127-19-5
CAS-Nr.
127-19-5
Bezeichnung:
N,N-Dimethylacetamid
Englisch Name:
N,N-Dimethylacetamide
Synonyma:
DMAC;U-5954;SK 7176;nsc3138;NSC 3138;OmniPure?;CBC 510337;CH3CON(CH3)2;Acetic acid-di;dimethylacetamid
CBNumber:
CB8853004
Summenformel:
C4H9NO
Molgewicht:
87.12
MOL-Datei:
127-19-5.mol

N,N-Dimethylacetamid Eigenschaften

Schmelzpunkt:
-20 °C
Siedepunkt:
164.5-166 °C(lit.)
Dichte
0.937 g/mL at 25 °C(lit.)
Dampfdichte
3.89 (vs air)
Dampfdruck
40 mm Hg ( 19.4 °C)
Brechungsindex
n20/D 1.439(lit.)
Flammpunkt:
158 °F
storage temp. 
0-6°C
Löslichkeit
>1000g/l soluble
Aggregatzustand
Liquid
pka
-0.41±0.70(Predicted)
Farbe
Colorless to yellowish
PH
4 (200g/l, H2O, 20℃)
Relative polarity
6.3
Explosionsgrenze
1.7-11.5%(V)
Wasserlöslichkeit
miscible
maximale Wellenlänge (λmax)
λ: 270 nm Amax: 1.00
λ: 280 nm Amax: 0.30
λ: 290 nm Amax: 0.15
λ: 310 nm Amax: 0.05
λ: 320 nm Amax: 0.03
λ: 360-400 nm Amax: 0.01
Merck 
14,3227
BRN 
1737614
Expositionsgrenzwerte
NIOSH REL: TWA 10 ppm (35 mg/m3), IDLH 300 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted).
Stabilität:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
FXHOOIRPVKKKFG-UHFFFAOYSA-N
CAS Datenbank
127-19-5(CAS DataBase Reference)
NIST chemische Informationen
Acetamide, N,N-dimethyl-(127-19-5)
EPA chemische Informationen
Acetamide, N,N-dimethyl-(127-19-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,Xn,T
R-Sätze: 11-20/22-61-20/21-36
S-Sätze: 16-24-53-45-36-28-26
RIDADR  UN 1279 3/PG 2
WGK Germany  3
RTECS-Nr. TX9625000
3-10
Selbstentzündungstemperatur 914 °F
TSCA  Yes
HS Code  29241900
Giftige Stoffe Daten 127-19-5(Hazardous Substances Data)
Toxizität LD50 orally in rats: 5.4 ml/kg (Bartsch)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H227 Combustible liquid Flammable liquids Category 4 Warnung P210, P280, P370+P378, P403+P235,P501
H312 Gesundheitsschädlich bei Hautkontakt. Akute Toxizität dermal Kategorie 4 Warnung P280,P302+P352, P312, P322, P363,P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warnung P264, P305+P351+P338,P337+P313
H332 Gesundheitsschädlich bei Einatmen. Akute Toxizität inhalativ Kategorie 4 Warnung P261, P271, P304+P340, P312
H336 Kann Schläfrigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Schläfrigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
H372 Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 1 Achtung P260, P264, P270, P314, P501
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.
P403+P233 An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

N,N-Dimethylacetamid Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

öLIGE, FARBLOSE FLüSSIGKEIT MIT STECHENDEM GERUCH.

CHEMISCHE GEFAHREN

Die Substanz zersetzt sich beim Erwärmen unter Bildung von giftigen Rauchen. Reagiert mit starkenOxidationsmitteln.

ARBEITSPLATZGRENZWERTE

TLV: 10 ppm (als TWA); Hautresorption; Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); BEI vorhanden (ACGIH 2006).
EG Arbeitsplatz-Richtgrenzwerte: 36 mg/m?(als TWA), 72 mg/m?(als STEL) Hautresorption (EU 2006).
MAK: 10 ppm, 36 mg/m? Spitzenbegrenzung: überschreitungsfaktor II(2); Hautresorption; Schwangerschaft: Gruppe C (DFG 2008).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation und über die Haut.

INHALATIONSGEFAHREN

Beim Verdampfen bei 20°C tritt langsam eine gesundheitsschädliche Kontamination der Luft ein

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Möglich sind Auswirkungen auf die Leber mit nachfolgenden Funktionsstörungen. Tierversuche zeigen, dass die Substanz möglicherweise fruchtbarkeitsschädigend oder entwicklungsschädigend wirken kann.

LECKAGE

Persönliche Schutzausrüstung:Chemikalienschutzanzug. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.

R-Sätze Betriebsanweisung:

R11:Leichtentzündlich.
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
R61:Kann das Kind im Mutterleib schädigen.
R20/21:Gesundheitsschädlich beim Einatmen und bei Berührung mit der Haut.
R36:Reizt die Augen.

S-Sätze Betriebsanweisung:

S16:Von Zündquellen fernhalten - Nicht rauchen.
S24:Berührung mit der Haut vermeiden.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

colourless liquid with a faint ammonia odour

Chemische Eigenschaften

Dimethylacetamide occurs as a clear, colorless, slightly hygroscopic liquid. It has a weak ammonia-like or fish-like odor.

Physikalische Eigenschaften

Clear, colorless liquid with a weak, ammonia-like odor. Odor threshold concentration is 46.8 ppmv (Leonardos et al., 1969).

Verwenden

Solvent for many organic reactions and in industrial applications.

Definition

ChEBI: A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.

Vorbereitung Methode

Dimethylacetamide has been produced by the reaction of acetic acid with dimethylamine (Siegle, 1980).

Vorbereitung Methode

Dimethylacetamide is manufactured from acetic acid and dimethylamine in a closed system.

Allgemeine Beschreibung

A clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145°F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin.

Air & Water Reaktionen

Water soluble.

Reaktivität anzeigen

N,N-Dimethylacetamide is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. N,N-Dimethylacetamide can react violently in the presence of iron. Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.

Health Hazard

Liquid causes mild irritation of eyes and skin. Ingestion causes depression, lethargy, confusion and disorientation, visual and auditory hallucinations, perceptual distortions, delusions, emotional detachment, and affective blunting.

Health Hazard

A study of 41 workers who had been exposed to dimethylacetamide from 2 to 10 years revealed the occurrence of disorders reflecting liver damage (Corsi, 1971). Retention of bromosulfophthalein was increased in 9 of 10 workers who had been exposed to dimethylacetamide for 7 to 10 years, and in 10 of 20 workers who had been exposed to dimethylacetamide for 2 to 7 years. Other parameters of hepatic function which were altered in the exposed individuals include proteinemia, cholesterolemia, activities of hepatic transaminases and alkaline phosphatase in serum, and bilirubinemia. Hepatomegaly was diagnosed in 14 workers.
In a clinical trial, dimethylacetamide was administered to patients with advanced malignancies and caused abnormal mental states (Weiss et al 1962a, b). This effect was observed at a dose of 400 mg/kg given daily for 3 or more days.
The symptoms were not seen at 300 mg/kg or lower. The second or third dose caused depression, lethargy, occasional confusion or disorientation. The fourth or fifth dose produced striking hallucinations, perceptual distortions and delusions in all nine patients. All patients reverted to normal several days after discontinuation of treatment with dimethylacetamide.

Brandgefahr

N,N-Dimethylacetamide is combustible.

Pharmazeutische Anwendungen

Dimethylacetamide is used as a solvent in oral and injectable pharmaceutical formulations. It has been used as a cosolvent to solubilize poorly soluble drugs. The use of dimethylacetamide has also been investigated as a vehicle for the parenteral delivery of relatively small peptides.
The use of solvents such as dimethylacetamide has been shown to influence the size and rate of release of norfloxacin from nanoparticles.
Dimethylacetamide has also been used in topical formulations and has been evaluated as a permeation enhancer for transdermal drug delivery.

Industrielle Verwendung

Dimethylacetamide is a powerful industrial solvent, the uses of which are very similar to those of dimethylformamide (Siegle, 1980). Its strong solvent action renders it particularly useful in the manufacture of films and fibers and as a solvent for polyacrylonitrile, polyvinyl chloride, polyamides, cellulose derivatives and polystyrenes and in coatings and adhesive formulations. Dimethylacetamide dissolves many inorganic salts.

Sicherheitsprofil

Moderately toxic by skin contact, inhalation, intravenous, and intraperitoneal routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. A skin and eye irritant. Less toxic than dimethylformamide. Mutation data reported. Combustible when exposed to heat and flame. A moderate explosion hazard. Violent reaction with halogenated compounds (e.g., carbon tetrachloride, hexachlorocyclohexane) when heated above 9OOC. Iron powder catalyzes the reaction so that it initiates at 71OC. When heated to decomposition it emits toxic fumes of NOx

Sicherheit(Safety)

Dimethylacetamide is used in pharmaceutical preparations as a solvent in parenteral formulations and is generally regarded as a nontoxic material when used as an excipient. Animal toxicity studies indicate that dimethylacetamide is readily absorbed into the bloodstream following inhalation or topical application. Repeated exposure to dimethylacetamide may be harmful and can result in liver damage. High intravenous doses (>400mg/kg/day for 3 days) may be hallucinogenic.
LD50 (rabbit, SC): 9.6g/kg(11) LD50 (rat, IP): 2.75g/kg LD50 (rat, IV): 2.64g/kg LD50 (rat, oral): 4.93g/kg LD50 (mouse, inhalation): 7.2g/kg LD50 (mouse, IP): 2.8g/kg

Environmental Fate

Chemical/Physical. Releases toxic fumes of nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).

Stoffwechsel

Gas Chromatographie analysis of the urine of rats which had received dimethylacetamide by the subcutaneous route indicated the presence of N-methyl-acetamide and acetamide (Barnes and Ranta, 1972). Both metabolites were also found by the same authors in incubation mixtures of dimethylacetamide with rat liver homogenate. N-Methylacetamide was detected in the urine of human volunteers who had inhaled dimethylacetamide or absorbed dimethylacetamide vapor through the skin (Maxfield et al 1975). Measurement of the amount of the metabolite N-methylacetamide excreted by individuals exposed to dimethylacetamide vapors with or without face masks which allowed the inhalation of air free of dimethylacetamide indicated that more dimethylacetamide was absorbed through the lungs than through the skin. Interestingly, in this study, only 2-10% of the amount of dimethylacetamide inhaled was recovered in the urine in the form of N-methylacetamide. It has been suggested that the major urinary metabolite of the analogous dimethylformamide is N-(hydroxymethyl)-N-methylformamide and not N-methylformamide, since the carbinolamide decomposes on the gas chroma-tography column (to N-methylformamide) but is relatively stable in aqueous solution (Kestell et al 1986). In analogy, it would be logical to assume that the N-methylacetamide found in the urine after exposure to dimethylacetamide really arose from chemical breakdown of N-(hydroxymethyl)-N-methylacetamide during the analytical process. This contention, however, remains to be proven.

Lager

Dimethylacetamide should be stored in an airtight container, protected from light, in a cool, dry place. Dimethylacetamide has an almost unlimited shelf-life when kept in closed containers and under nitrogen. It is combustible.

läuterung methode

Shake the amide with BaO for several days, reflux it with BaO for 1hour, then fractionally distil it under reduced pressure. Store it over molecular sieves. [Beilstein 4 IV 180.]

Inkompatibilitäten

Dimethylacetamide is incompatible with carbon tetrachloride, oxidizing agents, halogenated compounds, and iron. It attacks plastic and rubber. Contact with strong oxidizers may cause fire.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM injections, IV injections and infusions). Included in parenteral medicines licensed in the UK.

N,N-Dimethylacetamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N,N-Dimethylacetamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 444)Lieferanten
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Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
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86-0551-65418684 18949823763
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127-19-5(N,N-Dimethylacetamid)Verwandte Suche:


  • dimethylacetoneamide
  • Dimethylamid kyseliny octove
  • Dimethylamide acetate
  • dimethylamideacetate
  • dimethylamidkyselinyoctove
  • n,n-dimethyl-acetamid
  • n,n-dimethylacetamidesolution(40%orless)
  • N,N-Dimethylethanamide
  • NSC 3138
  • nsc3138
  • SK 7176
  • N N-DIMETHYLACETAMIDE DIST. 1 L
  • N,N-DIMETHYLACETAMIDE, ABS., O. MOLEC.-S IEVE (H2O <0.01%)
  • N N-DIMETHYLACETAMIDE ALDRASORB 99.8%
  • N,N-DIMETHYLACETAMIDE 'B&J BRAND'
  • N,N-DIMETHYLACETAMIDE, 99+%, SPECTROPHOT O-METRIC GRADE
  • N,N-DIMETHYLACETAMIDE, REAGENTPLUS, >=99%
  • N,N-DIMETHYLACETAMIDE, STANDARD FOR GC
  • N,N-DIMETHYLACETAMIDE, 99.9+%, HPLC GRAD E
  • N,N-DIMETHYLACETAMIDE GC STANDARD
  • N,N-DimethylacetamideC4H9NO>99%
  • N,N-DimethylacetamideCertified
  • DimethylAcetamideGr
  • N,N-Dimethylacetamide, extra pure, 99.5%
  • N,N-Dimethylacetamide, extra pure, 99+%
  • N,N-Dimethylacetamide, for analysis
  • N,N-Dimethylacetamide, for spectroscopy, 99+%
  • N,N-Dimethylacetamide, pure, 99%
  • N,N-Dimethylacetamide, water <100ppm, extra dry over mol. sieve
  • N,N-DIMETHYLACETAMIDE DISTILLED IN QUARTZ SOLVENT
  • N,N-DIMETHYLLACETAMIDE
  • Acetamide, N,N-dimethyl-
  • n,n-dimethylacetamide, hplc grade
  • N,N-DIMETHYLACETAMIDE,ANHYDROUS
  • N,N-DIMETHYLACETAMIDE,OMNISOLV
  • N,N-DIMETHYLACETAMIDE,REAGENT
  • Acetdimethylamide
  • Acetic acid dimethylamide
  • Dimethyl acetamide
  • DMAC
  • N,N-Dimethylacetamide
  • U-5954
  • N,N-Dimethylacetamide, HPLC Grade, 99.5+%
  • Dimethylacetamide, N,N-
  • N,N-DIMETHYLACETAMIDE extrapure
  • N,N-Dimethylacetamide, extra dry over molecular sieve
  • N,N-Dimethylacetamide, 99.5%, extra pure
  • N,N-DIMETHYLACETAMIDE, EXTRA DRY
  • N,N-Dimethylacetamide, for spectroscopy
  • N,N-DimethylacetamideAcroSealExtra Dry over Molecular Sieve
  • N,N-DimethylacetamideAcroSealExtra Dry
  • N,N-Dimethylacetamide, anhydrous, 99.8%, packaged under Argon in resealable ChemSeal^t bottles
  • N,N-Dimethylacetamide,99.5%,Extra Dry
  • N,N-Dimethylacetamide,99.5%,Extra Dry over Molecular Sieve
  • N,N-Dimethylacetamide, anhydrous, 99.8%, packaged under Argon in resealable ChemSealTM bottles
  • N,N-Acetyldimethylamine
  • N,N-Dimethylacetamide ,98%
  • N,N-Dimethylacetamide, AcroSeal, Extra Dry over Molecular Sieve, 99.5%
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