6-HYDROXYMELATONIN
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- CAS-Nr.
- 2208-41-5
- Englisch Name:
- 6-HYDROXYMELATONIN
- Synonyma:
- Sutan (Butylate);6-HYDROXYMELATONIN;6-Hydroxymelatonine;MELATONIN, 6-HYDROXY;Melatonin 6-Hydroxy Impurity;6Hydroxymelatonin,6 Hydroxymelatonin;N-ACETYL-6-HYDROXY-5-METHOXYTRYPTAMINE;6-HYDROXY-N-ACETYL-5-METHOXYTRYPTAMINE;Melatonin Impurity 3 (6-Hydroxy Melatonin);3-[N-ACETYLAMINOETHYL]-6-HYDROXY-5-METHOXYINDOLE
- CBNumber:
- CB4436858
- Summenformel:
- C13H16N2O3
- Molgewicht:
- 248.28
- MOL-Datei:
- 2208-41-5.mol
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6-HYDROXYMELATONIN Eigenschaften
- Schmelzpunkt:
- 172-175°C
- Siedepunkt:
- 564.7±50.0 °C(Predicted)
- Dichte
- 1.266±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- Löslichkeit
- alcohol: soluble
- Aggregatzustand
- Solid
- pka
- 10.12±0.40(Predicted)
- Farbe
- White to Beige
- InChIKey
- OMYMRCXOJJZYKE-UHFFFAOYSA-N
6-HYDROXYMELATONIN Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
6-hydroxy Melatonin is an active metabolite of melatonin . It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT
1A), MT
1B, and MT
2 receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC
50 = 0.0016 μM). 6-hydroxy Melatonin (10 and 100 μM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an
in vitro model of sepsis. It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.
Chemische Eigenschaften
Off-White to Pale Beige Solid
Verwenden
6-Hydroxymelatonin has been used as a melatonin derivative to test its protective effects in ultra violet B (UVB)-induced oxidative stress melanocytes and keratinocytes.
Definition
ChEBI: A member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6.
Allgemeine Beschreibung
6-Hydroxymelatonin (6-OHM) is a melatonin metabolite. It is produced in the liver by the action of cytochrome P450 enzyme as well as by photodegradation of melatonin. In the central nervous system, it exists as a sulfated form. 6-OHM is a partial melatonin receptor MT2 agonist.
6-HYDROXYMELATONIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-HYDROXYMELATONIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 69)Lieferanten
2208-41-5()Verwandte Suche:
- N-Acetyl-5-methoxy-6-hydroxy-1H-indole-3-ethanamine
- N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]ethanamide
- Sutan (Butylate)
- MELATONIN, 6-HYDROXY
- 3-[N-ACETYLAMINOETHYL]-6-HYDROXY-5-METHOXYINDOLE
- 6-HYDROXYMELATONIN
- 6-HYDROXY-N-ACETYL-5-METHOXYTRYPTAMINE
- N-ACETYL-6-HYDROXY-5-METHOXYTRYPTAMINE
- n-(2-(6-hydroxy-5-methoxyindol-3-yl)ethyl)-acetamid
- N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
- 3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol
- N-[2-(5-Methoxy-6-hydroxy-1H-indole-3-yl)ethyl]acetamide
- Acetamide, N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-
- Melatonin 6-Hydroxy Impurity
- Melatonin Impurity 3 (6-Hydroxy Melatonin)
- 6-Hydroxymelatonine
- 6Hydroxymelatonin,6 Hydroxymelatonin
- 2208-41-5
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Various Metabolites and Impurities
- Metabolites
