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T0070907

T0070907 Struktur
313516-66-4
CAS-Nr.
313516-66-4
Englisch Name:
T0070907
Synonyma:
CS-2314;T 0070907;T0070907 USP/EP/BP;T0070907 (T-0070907;2-CHLORO-5-NITRO-N-(4-PYRIDYL)BENZAMIDE;2-CHLORO-5-NITRO-N-4-PYRIDINYLBENZAMIDE;T0070907 - CAS 313516-66-4 - Calbiochem;N1-(4-PYRIDYL)-2-CHLORO-5-NITROBENZAMIDE;BenzaMide, 2-chloro-5-nitro-N-4-pyridinyl-
CBNumber:
CB4771443
Summenformel:
C12H8ClN3O3
Molgewicht:
277.66
MOL-Datei:
313516-66-4.mol
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T0070907 Eigenschaften

Schmelzpunkt:
>184°C (dec.)
Dichte
1.498
storage temp. 
2-8°C
Löslichkeit
DMSO: >10mg/mL
Aggregatzustand
White solid
Farbe
white
Wasserlöslichkeit
Soluble in DMSO at 10mg/ml. Insoluble in water.
Sensitive 
Light Sensitive
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-36
S-Sätze: 26
WGK Germany  2
HS Code  29333990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

T0070907 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs). TZDs are a group of structurally related synthetic PPARγ receptor agonists with antidiabetic actions in vivo. There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. T0070907 is a potent and selective antagonist of the human PPARγ with an apparent IC50 of 1 nM for the binding inhibition of rosiglitazone, a reference TZD. T0070907 covalently binds to Cys313 of PPARγ, inducing conformational changes that block the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer.

Chemische Eigenschaften

Off-White Solid

Verwenden

T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.

Allgemeine Beschreibung

T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.

Biologische Aktivität

Potent and selective PPAR γ antagonist (IC 50 = 1 nM). Displays > 800-fold selectivity for PPAR γ over PPAR α and PPAR δ . In vitro, blocks transcriptional activity of PPAR γ and inhibits rosiglitazone-induced adipogenesis.

T0070907 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

T0070907 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 134)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29322 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Sichuan Biosynce Pharmatech Co., Ltd. 		+8619950309693
 diane@biosynce.com China 4874 58

313516-66-4()Verwandte Suche:

Linolsure Linolensure N-Pyridin-4-ylacetamid N-4-Pyridylbenzamid
  • 2-CHLORO-5-NITRO-N-4-PYRIDINYLBENZAMIDE
  • 2-CHLORO-5-NITRO-N-(4-PYRIDYL)BENZAMIDE
  • T 0070907
  • N1-(4-PYRIDYL)-2-CHLORO-5-NITROBENZAMIDE
  • BenzaMide, 2-chloro-5-nitro-N-4-pyridinyl-
  • T0070907 - CAS 313516-66-4 - Calbiochem
  • CS-2314
  • T0070907 (T-0070907
  • T0070907 USP/EP/BP
  • 313516-66-4
  • C12H8N3O3Cl
  • Intracellular receptor
  • PPARγ antagonist
  • Inhibitor
  • Inhibitors
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