STEM CELL FACTOR, HUMAN
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- CAS-Nr.
- 133352-98-4
- Englisch Name:
- STEM CELL FACTOR, HUMAN
- Synonyma:
- RHSCF;HUMAN SF;HUMAN SCF;HUMAN MGF;SCF, HUMAN;REC SCF (HUMAN);C-KIT LIGAND HUMAN;HUMAN STEEL FACTOR;HUMAN C-KIT LIGAND;RECOMBINANT HUMAN SCF
- CBNumber:
- CB5149605
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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STEM CELL FACTOR, HUMAN Eigenschaften
- storage temp.
- −20°C
- Aggregatzustand
- powder
STEM CELL FACTOR, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
The KITLG (KIT ligand) gene is mapped to human chromosome 12q21.32.
Biochem/physiol Actions
Stem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors.
STEM CELL FACTOR, HUMAN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
STEM CELL FACTOR, HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 75)Lieferanten
133352-98-4()Verwandte Suche:
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Ethylisocyanacetat
Phenylselenol
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
(Pentan-2,4-dionato-O,O')silber
(p-Toluolsulfonyl)methylisocyanid
1,1,3,3-Tetramethylbutylisocyanat
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
2-Methylpropylisocyanid
Tris(pentan-2,4-dionato)eisen(II)
Kupfer(II)-4-oxopent-2-en-2-olat
Aluminiumtris(2,4-pentandionato-O,O')
Methylisocyanacetat
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
N-Butylisocyanid
- RECOMBINANT HUMAN SCF
- REC STEM CELL FACTOR (HUMAN)
- REC SCF (HUMAN)
- SCF, HUMAN
- STEM CELL FACTOR, HUMAN
- STEM CELL FACTOR, HUMAN, RECOMBINANT
- STEM CELL FACTOR, HUMAN, RECOMBINANT, E COLI
- MAST CELL GROWTH FACTOR HUMAN
- C-KIT LIGAND HUMAN
- HUMAN SF
- HUMAN SCF
- HUMAN SCF/C-KIT LIGAND
- HUMAN STEEL FACTOR
- HUMAN STEM CELL FACTOR
- HUMAN STEM CELL FACTOR/C-KIT LIGAND
- HUMAN C-KIT LIGAND
- HUMAN MGF
- HUMAN MAST CELL GROWTH FACTOR
- c-Kit Ligand, Mast Cell Growth Factor (MGF)
- RHSCF
- 133352-98-4
