Antu (ISO) Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
WEISSES, GERUCHLOSES, KRISTALLINES PULVER.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen unter Bildung giftiger Gaseund giftiger Rauche mit Stickstoffoxiden, Schwefeloxidenund Kohlenmonoxid. Reagiert mit starken Oxidationsmitteln unter Feuer- und Explosionsgefahr.
ARBEITSPLATZGRENZWERTE
TLV: 0,3 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK: 0,3 mg/m?(Einatembare Fraktion); Spitzenbegrenzung: überschreitungsfaktor II(2); (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Exposition gegenüber der Substanz kann zu Lungenödem führen. ärztliche Beobachtung notwendig.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P3-Filter für giftige Partikel.
R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S25:Berührung mit den Augen vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
Beschreibung
a-Naphthylthiourea (ANTU; also called DIRAX) is toxic by
inhalation, ingestion, or skin contact. Due to its very narrow
spectrum of activity, production was discontinued a long time
ago. Exposure to ANTU causes pulmonary edema; therefore, it
is often used as an experimental pneumotoxin. ANTU is a graycolored,
prism-shaped, odorless powder with a bitter taste. It
has a molecular weight of 202.28 and melting point of 200 ℃
and does not ignite readily. However, on interaction with
potential oxidizing agents, it may cause fire and explosions,
which can lead to hazardous decomposition products such as
sulfur dioxide, nitrogen dioxide, and carbon monoxide. The
structure of ANTU contains the naphthalene chromophore,
which absorbs UV light at ～311 nm. This suggests that ANTU
can undergo photolysis.
Chemische Eigenschaften
greyish to beige-brown crystals or cryst. powder
Physikalische Eigenschaften
Colorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste.
Verwenden
Rodenticide. Specific control for the adult Norway rat; less toxic to other rat species.
Allgemeine Beschreibung
White crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S.
Air & Water Reaktionen
Slightly soluble in water.
Reaktivität anzeigen
1-(1-NAPHTHYL)-2-THIOUREA is incompatible with the following: Strong oxidizers, silver nitrate .
Hazard
Toxic by ingestion
Health Hazard
Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk.
Brandgefahr
Emits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. 1-(1-NAPHTHYL)-2-THIOUREA reacts with silver nitrate and strong oxidizers. Avoid decomposing heat.
Sicherheitsprofil
Poison by ingestion and
intraperitoneal routes. Moderately toxic to
humans by an unspecified route.
Questionable carcinogen with experimental
tumorigenic data. Mutagenic data. A
rodenticide used extensively. Death is
caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis
and a decrease in the white blood cells.
When heated to decomposition it emits
toxic fumes of NOx and SOx.
mögliche Exposition
ANTU or its formulations are used as
a rodenticide.
Carcinogenicity
ANTU was not carcinogenic in rodent
feeding studies.4 Cases of bladder tumors
among rat catchers exposed to ANTU have
been attributed to b-naphthylamine, a manufacturing
impurity of ANTU. In bacterial
assays ANTU induced mutations.
Environmental Fate
Chemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25°C was
determined to be 8 × 10–5/hour, resulting in a half-life of 361 days (Ellington et al., 1988)
Emits very toxic fumes of nitrogen and sulfur oxides when heated to decomposition
(Lewis, 1990)
Lager
α-Naphthalene thiourea should be kept stored in a tightly closed container in a locked
poison room, in a cool, dry, well-ventilated area away from incompatible substances.
Versand/Shipping
UN1651 Naphthylthiourea, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials.
läuterung methode
Crystallise ANTU from EtOH. [Beilstein 12 III 2941, 12 IV 3086.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, silver nitrate.
Waste disposal
Incinerate in a furnace
equipped with an alkaline scrubber. Consult with environmental
regulatory agencies for guidance on
acceptable disposal practices. Generators of waste containing
this contaminant (≥100 kg/mo) must conform with
EPA regulations governing storage, transportation, treatment,
and waste disposal.
Vorsichtsmaßnahmen
Workers should use/handle α-naphthalene thiourea with adequate ventilation. During
use, dust generation and accumulation should be minimum, and avoid contact with the
eyes, skin, and clothing.
Antu (ISO) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
