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9,10-Secocholesta-5,7,10(19)-trien-3-ol Produkt Beschreibung

Vitamin D3 Struktur
67-97-0
CAS-Nr.
67-97-0
Bezeichnung:
9,10-Secocholesta-5,7,10(19)-trien-3-ol
Englisch Name:
Vitamin D3
Synonyma:
Vi-De3;Ebivit;Oxarol;CALCIOL;Prezios;Devaron;FeraCol;Deparal;rampage;MC 1275
CBNumber:
CB6104867
Summenformel:
C27H44O
Molgewicht:
384.64
MOL-Datei:
67-97-0.mol

9,10-Secocholesta-5,7,10(19)-trien-3-ol Eigenschaften

Schmelzpunkt:
83-86 °C(lit.)
Siedepunkt:
451.27°C (rough estimate)
alpha 
105 º (c=0.8, EtOH 25 ºC)
Dichte
0.9717 (rough estimate)
Dampfdruck
2.0 x l0-6 Pa (20 °C, est.)
Brechungsindex
1.5100 (estimate)
Flammpunkt:
14 °C
storage temp. 
2-8°C
Löslichkeit
Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in trimethylpentane and in fatty oils. It is sensitive to air, heat and light. Solutions in solvents without an antioxidant are unstable and are to be used immediately. A reversible isomerisation to pre-cholecalciferol takes place in solution, depending on temperature and time. The activity is due to both compounds.
Aggregatzustand
powder
Wasserlöslichkeit
<0.1 g/L (20 ºC)
Sensitive 
Air & Light Sensitive
Merck 
14,10019
BRN 
2339331
CAS Datenbank
67-97-0(CAS DataBase Reference)
NIST chemische Informationen
Cholecalciferol(67-97-0)
EPA chemische Informationen
9,10-Secocholesta- 5,7,10(19)-trien-3-ol, (3.beta.,5Z,7E)-(67-97-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+,T,Xn,F
R-Sätze: 24/25-26-48/25-23/24/25-20-11-48
S-Sätze: 28-36/37-45-28A-36/37/39-16-7
RIDADR  UN 2811 6.1/PG 2
WGK Germany  2
RTECS-Nr. VS2900000
8-10-23
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29130000
HS Code  29362990
Giftige Stoffe Daten 67-97-0(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H311 Giftig bei Hautkontakt. Akute Toxizität dermal Kategorie 3 Achtung P280, P302+P352, P312, P322, P361,P363, P405, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H330 Lebensgefahr bei Einatmen. Akute Toxizität inhalativ Kategorie 1 Achtung P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H372 Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 1 Achtung P260, P264, P270, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P284 Atemschutz tragen.
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.
P320 Besondere Behandlung dringend erforderlich
P330 Mund ausspülen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P405 Unter Verschluss aufbewahren.
P403+P233 An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.

9,10-Secocholesta-5,7,10(19)-trien-3-ol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

White or colorless crystalline solid. Odorless;

Verwenden

Vitamin D3 analogue.

Verwenden

carnitine replenisher in peripheral arterial disease

Verwenden

The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that i s a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects o n breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Verwenden

selective phosphodiesterase-4 inhibitor (PDE-4 inhibitor) under investigation for treating respiratory diseases involving chronic inflammation such as asthma or COPD (smoker’s lung)

Verwenden

Cholecalciferol and ergocalciferol are used for the control of rats and mice.

Definition

A free vitamin D 3, isolated in crystalline state from the 3,5-dinitrobenzoate, produced by irradiation, and equivalent in activity to vitamin D3 of tunaliver oil.

Indications

Vitamin D is the collective term for a group of compounds formed by the action of ultraviolet irradiation on sterols. Cholecalciferol (vitamin D3) and calciferol (vitamin D2) are formed by irradiation of the provitamins 7- dehydrocholesterol and ergosterol, respectively. The conversion to vitamin D3 occurs in the skin. The liver is the principal storage site for vitamin D, and it is here that the vitamin is hydroxylated to form 25-hydroxyvitamin D. Additional hydroxylation to form 1,25-dihydroxyvitamin D occurs in the kidney in response to the need for calcium and phosphate

Indications

Vitamin D3, through its active metabolite, 1,25- (OH)2D3, also plays an important role in maintaining calcium homeostasis by enhancing intestinal calcium absorption, PTH-induced mobilization of calcium from bone, and calcium reabsorption in the kidney.

Biosynthese

The primary supply of vitamin D3 in humans is not obtained from the diet but rather is derived from the ultraviolet photoconversion of 7-dehydrocholesterol to vitamin D3 in skin. Thus, vitamin D3 synthesis varies with the seasons. D3 is a prohormone and requires further metabolic conversion to exert biological activity in its target organs. The liver and the kidney are the major sites of metabolic activation of this endogenous sterol hormone. The initial transformation of D3 occurs in the liver and is catalyzed by the enzyme 25-OH-D3-hydroxylase to form 25-(OH)D3; this is the primary circulating form of D3. Circulating 25-(OH)D3 is then converted by the kidney to the most active form of D3, 1,25-(OH)2D3, by the 1-(OH)-D3-hydroxylase enzyme. Blood concentrations of 1,25-(OH)2D3 are approximately one fivehundredth of those of 25-(OH)D3. 1, 25-(OH)2D3 is converted to the metabolite 24R,25-(OH)2D3, which is capable of suppressing parathyroid secretion.
In addition to the endogenous metabolites, some exogenous sterols possess biological activity similar to that of D3. Ergocalciferol (vitamin D2) is derived from the plant sterol ergosterol and may act as a substrate for both the 25-hydroxylase and the 1-hydroxylase enzyme systems of the liver and kidney to form 25-(OH)D2 and 1,25-(OH)2 D2, respectively. Ergocalciferol (vitamin D2) is the form used in commercial vitamins and supplemented dairy products. Dihydrotachysterol, another sterol that is used as a therapeutic agent, also functions as a substrate for the hydroxylase enzymes in the liver and kidney.

Allgemeine Beschreibung

Fine colorless crystals. Water insoluble.

Air & Water Reaktionen

Sensitive to moisture, air and light. . Water insoluble.

Reaktivität anzeigen

Vitamin D3 may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.

Health Hazard

SYMPTOMS: Symptoms of exposure to Vitamin D3 may include weakness, fatigue, lassitude headache, nausea, vomiting, diarrhea, polyuria, polydipsia, nocturia, decrease urinary concentrating ability, proteinuria, tissue calcification, hypertension and osteoporosis.

Brandgefahr

Flash point data for Vitamin D3 are not available. Vitamin D3 is probably combustible.

Landwirtschaftliche Anwendung

Rodenticide: Used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries. Registered for use in the U.S. and other countries.

Handelsname

DELSTEROL®; DEPARAL®; D3- VIGANTOL®; QUINTOX®; RAMPAGE®; RICKETON®; TRIVITAN®; VIGORSAN®; VITINC DAN-DEE-3®

Mechanism of action

1, 25-(OH)2D3 exerts its influence within target tissues through high-affinity sterol-specific intracellular receptor proteins.The D3 receptor, similar to steroid receptor systems, translocates the hormone from the cell cytoplasm to the nucleus, where biological response is initiated via transcription and translation.

Clinical Use

The principal disorder associated with inadequate vitamin D intake is rickets. The low blood calcium and phosphate levels that occur during vitamin D deficiency stimulate parathyroid hormone secretion to restore calcium levels. In children, this deficiency leads to the formation of soft bones that become deformed easily; in adults, osteomalacia results from the removal of calcium from the bone.Vitamin D deficiency may occur in patients with metabolic disorders, such as hypoparathyroidism and renal osteodystrophy. The requirement for vitamin D is slightly higher in members of darker-pigmented races, since melanin interferes with the irradiation that produces vitamin D3 in the skin. People with limited exposure to the sun may need to supplement vitamin D intake.

Nebenwirkungen

The hypercalcemia resulting from hypervitaminosis D is responsible for toxic symptoms such as muscle weakness, bone pain, anorexia, ectopic calcification, hypertension, and cardiac arrhythmias. Toxicity in infants can result in mental and physical retardation, renal failure, and death.

Sicherheitsprofil

Poison by ingestion. An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

mögliche Exposition

Sterol rodenticide used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries

Stoffwechselwegen

Cholecalciferol (vitamin D3) is the mammalian form of vitamin D. It is normally produced in the skin by the action of UV light on its precursor, 7- dehydrocholesterol. Essential amounts of the vitamin are obtained thus or from dietary sources such as fish oils. The active form of the vitamin is 1,25-dihydroxy-cholecalciferol. Its formation occurs in two stages: 25- hydroxylation in the liver, followed by 1-hydroxylation in the kidney (see Engstrom and Koszewski, 1989 and references cited therein).

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

läuterung methode

It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 III 2811, 6 IV 4149.]

Degradation

It is unstable in light and air and in acidic media. It is inactivated within a few days under normal exposure conditions. This is due to oxidation and fragmentation of the triene functionality.

Inkompatibilitäten

Sensitive to air, light, and moisture. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste disposal

Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

9,10-Secocholesta-5,7,10(19)-trien-3-ol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


9,10-Secocholesta-5,7,10(19)-trien-3-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 373)Lieferanten
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Shenzhen Sendi Biotechnology Co.Ltd.
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
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67-97-0(9,10-Secocholesta-5,7,10(19)-trien-3-ol)Verwandte Suche:


  • Dry Vitamin D3
  • RACUMIN D
  • OLEOVITAMIN D3
  • (+)-VITAMIN D3
  • VITAMIN D3
  • VITAMIN D
  • (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
  • (5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
  • 10-Secocholesta-5,7,10(19)-trien-3-ol,(3.beta.,5Z,7E)-9
  • 7,10(19)-trien-3-ol,(3beta,5z,7e)-10-secocholesta-5
  • 7-Dehydrocholestrol, activated
  • 7-dehydrocholestrol,activated
  • 9,10-Secocholesta-5,7,10(19)-trien-3-ol
  • 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3beta,5Z,7E)-
  • arachitol
  • Cholecalciferol, D3
  • vi-de-3-hydrosol
  • Vigorsan
  • Vitinc Dan-Dee-3
  • vitincdan-dee-3
  • ANTI-RACHITIC VITAMIN
  • CALCIOL
  • CHOLECALCIFEROL
  • CHOLECALCIFEROLUM
  • COLECALCIFEROL
  • 9,10-SECOCHOLESTA-5,7,10(19)-TRIEN-3BETA-OL
  • 9,10-SECOCHOLESTA-5,7,19(19)-TRIEN-3-OL-(3B,5Z,7E)-CHOLECIFEROL
  • 7-DEHYDROCHOLESTEROL ACTIVATED
  • ACTIVATED 7-DEHYDROCHOLESTEROL
  • Prezios
  • Sch 209579
  • 9,10-Secocholesta-5,7,10(19)-trien-3b-ol
  • 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3β,5Z,7E)- (9CI)
  • Cholecalciferol (8CI)
  • Devaron
  • FeraCol
  • Granuvit D3
  • NSC 375571
  • Vi-De3
  • Videkhol
  • Vitamin D3 / Cholecalciferol
  • 1,25-dihydroxy-22-oxavitamin D3
  • 22-OXA-1ALPHA,25-DIHYDROXYVITAMIND3
  • Vitamin D3 Crystal
  • 1A-HYDROXY VITAMIN D3
  • (25-Hydroxycholecalciferol-26,26,26,27,27,27-d6)
  • Vitamin-D3 (not deuterated)
  • VITAMIN D3 (CRYSTALS,CHOLECALCIFEROL)
  • VITAMIN D3 OIL (1,000,000IU/G)
  • VITAMIN D3 OIL (4,000,000IU/G)
  • 5,7-cholestadien-3betal-ol
  • Vitamin D3 Oil 10M EQ STAB
  • Activated 7-dehydrocholesterol,Calciol
  • (3,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
  • (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol
  • (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol, Cholecalciferolum
  • (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol, Cholecalciferol
  • Vitamin D3 Aeatate
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