콜레칼시페롤

콜레칼시페롤 속성

콜레칼시페롤 MSDS

9,10-Secocholesta-5,7,10(19)-trien-3beta-ol

콜레칼시페롤 C화학적 특성, 용도, 생산

개요

비타민 D는 비타민D2와 비타민 D3로 나뉜다. 비타민 D2는 식물에, D3는 동물에 많이 포함되어 있으며, 비타민 D3가 사람에 중요한 역할을 하고 있다.

용도

비타민D는 지방에 융해되는 비타민으로서 골격 형성에 필요한 칼슘을 대장과 콩팥에서 흡수시키는 데 기여하며 또한 부갑상선에서 생산되는 파라토르몬 과 칼시토닌과 협동으로 칼슘을 알맞게 골수로 운반하여 뼈대가 제모양으로 크도록 하는데 결정적인 역할을 한다.

순도시험

  (1) 비선광도 : 이 품목 약 0.1g을 정밀히 달아 에탄올에 녹여 200mL로 하고 이 액의 선광도를 측정할 때, ＝+103～+112°이어야 한다.

  (2) 비흡광도 : 이 품목을 알데히드를 함유하지 않은 에탄올에 녹여 파장 265nm에서 흡광도를 측정할 때, ＝450～490이어야 한다.

  (3) 7-데히드로콜레스테롤 : 이 품목 10mg을 90% 에탄올 2mL에 녹이고 디기토닌 20mg을 90% 에탄올 2mL에 녹인 액을 가하여 18시간 방치할 때, 침전이 생겨서는 아니 된다.

  (4) 융점 : 이 품목의 융점은 84～89℃이어야 한다.

보존기준

  차광한 밀봉용기에 넣고 공기를 질소가스로 바꾸어 찬 곳에 보존하여야 한다.

확인시험

  (1) 「비타민D₂」의 확인시험 (1)에 따라 시험한다. 다만, 그 융점은 133～135℃이다.

  (2) 「비타민D₂」의 확인시험 (2)에 따라 시험한다.

화학적 성질

White or colorless crystalline solid. Odorless;

용도

Vitamin D3 analogue.

Indications

Vitamin D is the collective term for a group of compounds formed by the action of ultraviolet irradiation on sterols. Cholecalciferol (vitamin D₃) and calciferol (vitamin D₂) are formed by irradiation of the provitamins 7- dehydrocholesterol and ergosterol, respectively. The conversion to vitamin D3 occurs in the skin. The liver is the principal storage site for vitamin D, and it is here that the vitamin is hydroxylated to form 25-hydroxyvitamin D. Additional hydroxylation to form 1,25-dihydroxyvitamin D occurs in the kidney in response to the need for calcium and phosphate

정의

A free vitamin D 3, isolated in crystalline state from the 3,5-dinitrobenzoate, produced by irradiation, and equivalent in activity to vitamin D3 of tunaliver oil.

일반 설명

Fine colorless crystals. Water insoluble.

공기와 물의 반응

Sensitive to moisture, air and light. . Water insoluble.

반응 프로필

Vitamin D3 may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.

건강위험

SYMPTOMS: Symptoms of exposure to Vitamin D3 may include weakness, fatigue, lassitude headache, nausea, vomiting, diarrhea, polyuria, polydipsia, nocturia, decrease urinary concentrating ability, proteinuria, tissue calcification, hypertension and osteoporosis.

화재위험

Flash point data for Vitamin D3 are not available. Vitamin D3 is probably combustible.

농업용

Rodenticide: Used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries. Registered for use in the U.S. and other countries.

상품명

DELSTEROL®; DEPARAL®; D3- VIGANTOL®; QUINTOX®; RAMPAGE®; RICKETON®; TRIVITAN®; VIGORSAN®; VITINC DAN-DEE-3®

Mechanism of action

1, 25-(OH)₂D₃ exerts its influence within target tissues through high-affinity sterol-specific intracellular receptor proteins.The D₃ receptor, similar to steroid receptor systems, translocates the hormone from the cell cytoplasm to the nucleus, where biological response is initiated via transcription and translation.

Clinical Use

The principal disorder associated with inadequate vitamin D intake is rickets. The low blood calcium and phosphate levels that occur during vitamin D deficiency stimulate parathyroid hormone secretion to restore calcium levels. In children, this deficiency leads to the formation of soft bones that become deformed easily; in adults, osteomalacia results from the removal of calcium from the bone.Vitamin D deficiency may occur in patients with metabolic disorders, such as hypoparathyroidism and renal osteodystrophy. The requirement for vitamin D is slightly higher in members of darker-pigmented races, since melanin interferes with the irradiation that produces vitamin D₃ in the skin. People with limited exposure to the sun may need to supplement vitamin D intake.

부작용

The hypercalcemia resulting from hypervitaminosis D is responsible for toxic symptoms such as muscle weakness, bone pain, anorexia, ectopic calcification, hypertension, and cardiac arrhythmias. Toxicity in infants can result in mental and physical retardation, renal failure, and death.

Safety Profile

Poison by ingestion. An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

잠재적 노출

Sterol rodenticide used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries

신진 대사 경로

Cholecalciferol (vitamin D3) is the mammalian form of vitamin D. It is normally produced in the skin by the action of UV light on its precursor, 7- dehydrocholesterol. Essential amounts of the vitamin are obtained thus or from dietary sources such as fish oils. The active form of the vitamin is 1,25-dihydroxy-cholecalciferol. Its formation occurs in two stages: 25- hydroxylation in the liver, followed by 1-hydroxylation in the kidney (see Engstrom and Koszewski, 1989 and references cited therein).

운송 방법

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

Purification Methods

It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 III 2811, 6 IV 4149.]

비 호환성

Sensitive to air, light, and moisture. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

폐기물 처리

Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

콜레칼시페롤 준비 용품 및 원자재

원자재

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콜레칼시페롤 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Leading Chemical and Trading Co.,Ltd	+8615669938129	sales@leadingchemical.com	China	121	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	7433	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Wuhan Marco Pharmaceutical Technology Co., Ltd.	+86-86-18572802410 +8618572802410	sales@marcopht.com	China	55	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	893	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55

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