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5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Produkt Beschreibung

Genistein Struktur
446-72-0
CAS-Nr.
446-72-0
Bezeichnung:
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron
Englisch Name:
Genistein
Synonyma:
GEN;prunetol;GLYCITEN;GeniVida;NPI 031L;enistein;GENISTEIN;Bonistein;c.i.75610;genisteol
CBNumber:
CB6163787
Summenformel:
C15H10O5
Molgewicht:
270.24
MOL-Datei:
446-72-0.mol

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Eigenschaften

Schmelzpunkt:
297-298 °C
Siedepunkt:
333.35°C (rough estimate)
Dichte
1.2319 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
-20°C
Löslichkeit
DMSO: soluble
Aggregatzustand
powder
pka
6.51±0.20(Predicted)
Farbe
off-white
Wasserlöslichkeit
insoluble
Merck 
14,4391
BRN 
263823
Stabilität:
Light Sensitive
InChIKey
TZBJGXHYKVUXJN-UHFFFAOYSA-N
CAS Datenbank
446-72-0(CAS DataBase Reference)
EPA chemische Informationen
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- (446-72-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi,Xn
R-Sätze: 36/38-22
S-Sätze: 26-24/25-22
WGK Germany  3
RTECS-Nr. NR2392000
TSCA  Yes
HazardClass  IRRITANT
HS Code  29329990
Giftige Stoffe Daten 446-72-0(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/38:Reizt die Augen und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.

Chemische Eigenschaften

Yellow Crystalline Solid

Verwenden

genistein is an isoflavone commonly found in soy. It has demonstrated uV-protection properties through anti-oxidant activity. Studies indicate genistein can promote collagen synthesis, making it applicable in anti-aging cosmetics.

Verwenden

Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

Verwenden

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

Verwenden

cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase

Definition

ChEBI: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.

Biologische Aktivität

Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset™ .

Anticancer Research

It is an isoflavone and is obtained from a variety of plants like psoralea (Psoraleacorylifolia), kudzu (Pueraria lobata), faba beans (Vicia faba), and soybeans(Glycine max). It exhibits anticancer effect by inhibiting NF-κB and protein kinaseB (Akt) signaling pathways (Singh et al. 2016b). It blocks the proliferation of cancercells via the inhibition of cell growth enzymes and survival like tyrosine kinase andtopoisomerase II; hence it is used to treat leukemia. Genistein increases the growthrate of some estrogen receptors in breast cancer cells and the rate of proliferation of estrogen-dependent breast cancer by competitive binding to the estrogen-β receptors.It may be involved in JNK pathway in inducing activator protein-1(AP-1) activity(Wang et al. 2012; Dixon and Ferreira 2002).

Sicherheitsprofil

Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

läuterung methode

Crystallise it from EtOH or aqueous EtOH. It has UV: max at 290nm (EtOH). The S(-)-enantiomer (natural form) has m 255-256o (from EtOH) and [] D 20 -28.0o (c 2, EtOH), [ ] D 20 -35.2o (c 1, pyridine).[Beilstein 18 H 503, 18 II 164, 18 III/IV 2630.] Genistein (4',5,7-trihydroxyisoflavone) [446-72-0]M 270.2 crystallises from 60% aqueous EtOH or water with m 297-298o and [] D 20 -28o (c 0.6, 20mM NaOH). [Beilstein 18/4 V 594.]For Naringin (naringenin 7-rhamnoglucoside) See “Carbohydrates” in Chapter 6.

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 595)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Aktin Chemicals, Inc.
028-85159085
86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58

446-72-0(5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron)Verwandte Suche:


  • 4’,5,7-trihydroxy-isoflavon
  • prunetol
  • sophoricol
  • 4',5,7-TRIHYDROXYISOFLAVONE
  • 5,7,4'-TRIHYDROXYISOFLAVONE
  • 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
  • 5,7-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
  • AKOS NCG1-0029
  • GENISTEIN
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
  • GENISTEIN RESEARCH GRADE
  • Genistein,4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • GLYCITEN
  • Bonistein
  • Bonistein TG
  • Genistein (15 mg)
  • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
  • Golden sparrow isoflavone
  • GeniVida
  • NPI 031L
  • Genistein, synthetic, 99% 25MG
  • Genistein SynonyMs 4',5,7-Trihydroxyisoflavone
  • Genistein 0.25
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
  • c.i.75610
  • differenola
  • genistein(synthetic)
  • genisteol
  • genisterin
  • Natural Genistein
  • GENISTEIN FROM GLYCINE MAX (SOYBEAN)
  • GENISTEIN FROM SOYBEAN 98%(HPLC)
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
  • 4',5,7-trihydroisoflavon
  • Genistein98%,99%
  • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-(4H)-benzopyran-4-one
  • 4,5,7-TRIHYDROXYISO-FLAVONE(GENISTEIN)
  • GENESTEIN
  • GENISTEIN 98.0% (EXTRACTION)
  • GENISTEIN 98.5% (SYNTHETIC)
  • DIENISTEIN
  • Genistein 99.0%min
  • Genistein >98%
  • Genistein, 98% (4’,5,7-Trihydroxyisoflavone)
  • Genisteol&Prunetol
  • Genistein (C.I. 75610)
  • 4',5,7-Trihydroxyisoflavone
  • 4H-1-Benzopyran-4-one,5,7-dihydroxy-3-
  • Baichanin A
  • Genistein ,99%
  • GENISTEIN, 99%, SYNTHETIC
  • 4μ,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • Genista tinctoria Linn
  • 5,7-Trihydroxyisof
  • Bio1_000445
  • BRN 0263823
  • BSPBio_002375
  • CCRIS 7675
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