5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-on

5,7-Dihydrox -4'-methoxyisoflavone Struktur
491-80-5
CAS-Nr.
491-80-5
Bezeichnung:
5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-on
Englisch Name:
5,7-Dihydrox -4'-methoxyisoflavone
Synonyma:
BIOCHANIN A;BIOCHANIN;BIOCHANIN A (AHP);OlMelin;Pratensol;Bilchanin A;Biochani,Olmelin;5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one;5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one;NSC 123538
CBNumber:
CB8474490
Summenformel:
C16H12O5
Molgewicht:
284.26
MOL-Datei:
491-80-5.mol

5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-on Eigenschaften

Schmelzpunkt:
210-213 °C(lit.)
Siedepunkt:
340-355 °C(Press: 0.5 Torr)
Dichte
1.420±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
acetone: 10 mg/mL, clear, brown
pka
6.50±0.20(Predicted)
Aggregatzustand
Powder
Farbe
Off-White to Beige
Wasserlöslichkeit
Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C).
maximale Wellenlänge (λmax)
263nm(EtOH)(lit.)
BRN 
278107
LogP
3.341 (est)
CAS Datenbank
491-80-5(CAS DataBase Reference)
EPA chemische Informationen
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)- (491-80-5)

Sicherheit

S-Sätze: 22-24/25
WGK Germany  3
RTECS-Nr. DJ3002500
10
TSCA  Yes
HS Code  29329990

5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-on Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein , another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 μM).

Chemische Eigenschaften

Off-White Solid

Verwenden

An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene

Allgemeine Beschreibung

Biochanin A (BCA) is synthesized in vitro from phloroglucinol. A series of steps involving Friedel?Crafts reaction results in an intermediate product 1-(2,4,6-trihydroxyphenyl)-2-(4 methoxyphenyl) ethanone, which post cyclization leads to BCA. It is catabolized to isoflavone genistein post ingestion.

5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 362)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21691 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 296 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3424 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58

491-80-5(5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-on)Verwandte Suche:


  • 5,7-DIHYDROXY-4''-METHOXYISOFLAVONE, 98% BIOCHANIN A
  • 5,7-Dihydrox -4'-methoxyisoflavone
  • Biochanin A, (5,7-Dihydroxy-4’-methoxyisoflavone)
  • Biochanin A,Genistein 4'-methyl ether,5,7-Dihydrox -4'-methoxyisoflavone
  • 3-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 4'-Methylgenistein
  • NSC 123538
  • Biochanin A (4-Methylgenistein)
  • Biochanin A,5,7-Dihydroxy-4′-methoxyisoflavone, Genistein 4′-methyl ether
  • 5,7-dihydroxy-3-(4-methoxyphenyl)-4h-1-benzopyran-4-on
  • 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-Benzopyran-4-one
  • APIGENIN 4-METHYL ETHER
  • 5,7-DIHYDROXY-4'-METHOXYISOFLAVONE
  • 5,7-DIHYDROXY-4-METHOXYISOFLAVONE
  • 5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-
  • 5,7-Dihydroxy-4'-methoxyisoflavone Genistein 4'-methyl ether 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
  • 5,7-Dihydrox -4'-methoxyisoflavone 491-80-5
  • 7-hydroxy-3-(4-methoxyphenyl)-4-oxo-1-benzopyran-5-olate
  • Biochanin A >
  • Genistein Methyl Ether
  • Chickpea bud A
  • 5,7-Dihydroxy-4'-methoxyisoflavone (Biochanin A)
  • TIANFUCHEM--High purity 491-80-5 5,7-Dihydrox -4'-methoxyisoflavone
  • Biochani,Olmelin
  • 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one
  • BIOCHANIN A (AHP)
  • BIOCHANIN
  • 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
  • Bilchanin A
  • OlMelin
  • Pratensol
  • BIOCHANIN A
  • Genistein 4′-methyl ether
  • Chickpea sproutin A
  • Chickpea A
  • 5,7- Dihydroxy - 4'- methoxy Isoflovone (or) Biochanin-A
  • Chickpea sprout extract
  • Biochanin A 98%min
  • Chickpea dentin A
  • 491-80-5
  • Chromatography
  • Food & Beverage Standards
  • Food Residue Analysis
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • BioChemical
  • Cancer Research
  • Anti-proliferative Agents
  • Chemopreventive Agents
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Iso-Flavones
  • Inhibitors
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