2-Hydroxypropyl-β-cyclodextrin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White to slightly yellow powder
Verwenden
2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.
Vorbereitung Methode
Hydroxypropyl betadex is prepared by the treatment of an alkaline
solution of b-cyclodextrin with propylene oxide. The substitution
pattern can be influenced by varying the pH. Formation of O-6 and
O-2 substituted products is favored by high and low alkali
concentration, respectively. The mixture of products produced
may be refined by preparative chromatography.
Allgemeine Beschreibung
(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins.
Pharmazeutische Anwendungen
Hydroxypropyl betadex has been widely investigated in pharmaceutics
and has principally been used as a solubilizer for
hydrophobic molecules in oral liquids,oral solids, parenterals,
pressurized metered dose inhalers, dry powder inhalers,
and topical formulations. It has also been shown to act as a
stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported
to show mechanical properties distinct from the pure materials.
The reported advantage of hydroxypropyl betadex over unsubstituted
b-cyclodextrin is its greater water solubility.
Nebenwirkungen
2-Hydroxypropyl-β-cyclodextrin (HP-beta-CD) has been shown to be well tolerated in humans, with the main adverse event being diarrhoea and there have been no adverse events on kidney function, documented to date[1].
Sicherheit(Safety)
The pharmaceutical toxicology of hydroxypropyl betadex has been
reviewed, and in general, the material was found to be of low
toxicity. It has been suggested that hydroxypropyl betadex may
have a synergistic toxic effect with, for example, carcinogens, by
increasing their solubility and thus bioavailability.
Lager
Store in well-closed containers.
Regulatory Status
Included in oral and parenteral medicinal products. Included in an
injectable preparation licensed in the UK for intramuscular or
intravenous administration.
2-Hydroxypropyl-β-cyclodextrin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
