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2-Hydroxypropyl-β-cyclodextrin Produkt Beschreibung

2-Hydroxypropyl-β-cyclodextrin Struktur
128446-35-5
CAS-Nr.
128446-35-5
Englisch Name:
2-Hydroxypropyl-β-cyclodextrin
Synonyma:
HP-beta-CD;HPBCD/HPCD;CAVASOL(R)W7;Cavasol? W7 HP;2-Hydroxypropyl-βHydroxypropyl-b-Cyclodextrin;hydropropyl beta cyclodextrin;beta-hydroxypropylcyclodextrin;(2-Hydroxypropyl)-beta-cyclode;Hydroxypropyl Betadex (200 mg)
CBNumber:
CB6204503
Summenformel:
C63H112O42
Molgewicht:
1541.54
MOL-Datei:
128446-35-5.mol

2-Hydroxypropyl-β-cyclodextrin Eigenschaften

Schmelzpunkt:
278 °C (dec.)
Brechungsindex
125 ° (C=1, H2O)
storage temp. 
2-8°C
Löslichkeit
H2O: 45 % (w/v)
Aggregatzustand
solution (clear, colorless)
Farbe
White to slightly yellow
Optische Aktivität
[α]26/D +139°, c = 1 in H2O
Wasserlöslichkeit
Soluble in water.
InChIKey
ODLHGICHYURWBS-FOSILIAISA-N

Sicherheit

S-Sätze: 24/25
WGK Germany  3
RTECS-Nr. GU2293332
TSCA  Yes
HS Code  29400090

2-Hydroxypropyl-β-cyclodextrin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White to slightly yellow powder

Chemische Eigenschaften

Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

Verwenden

2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.

Verwenden

enteric coating, sustained release formulations, buccal and transdermal drug delivery

Verwenden

2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis

Vorbereitung Methode

Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.

Pharmazeutische Anwendungen

Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

Sicherheit(Safety)

The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.

Lager

Store in well-closed containers.

Regulatory Status

Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.

2-Hydroxypropyl-β-cyclodextrin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-Hydroxypropyl-β-cyclodextrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 251)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 360 57
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1018 58
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 136 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 12231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8922 58

128446-35-5()Verwandte Suche:


  • Hydroxypropyl beta cyclodextrin aqueous solution
  • Injection grade hydroxypropyl betadex
  • Pharmaceutical grade hydroxypropyl betadex
  • Technical grade hydroxypropyl beta cyclodextrin
  • beta-hydroxypropylcyclodextrin
  • (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
  • (2-Hydroxypropyl)-β-cyclodextrin
  • 2-Hydroxypropyl-B-Cyclodextrin
  • 2-HYDROXYPROPYL-B-CYCLODEXTRIN CELLCULTU RE TESTED
  • HYDROXYPROPYL-BETA-CYCLODEXTRIN (MS = 0. 8)
  • (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN (MS=1.0)
  • HYDROXYPROPYL-BETA-CYCLODEXTRIN, MS = 0. 6
  • Hydroxypropyl-b-Cyclodextrin
  • HP-beta-CD
  • CAVASOL(R)W7
  • HYDROXYPROPYL B-CYCLODEXTRIN USP, NF
  • (2-Hydroxypropyl)-β-cyclodextrin, avge. MW ca 1340
  • (2-Hydroxypropyl)-β-cyclodextrin, avge. MW ca 1400
  • injection hydroxypropyl-beta-cyclodextrin
  • Hydroxypropyl Beta Cyclodextrin sythetic
  • Cavasol? W7 HP
  • 2-Hydroxypropyl-&beta
  • (2-Hydroxypropyl)-beta-cyclodextrin average Mw ~1,540
  • (2-Hydroxypropyl)-beta-cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany
  • 2-hydroxypropyl-beta-cyclodextirn
  • Hydroxypropyl-β-cyclodextrin(HP-β-CD)
  • (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)
  • hydropropyl beta cyclodextrin
  • HP-β-CD, hydroxypropyl-β-cyclodextrin
  • beta-cyclodextrin,2-hydroxypropylether
  • (2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1340
  • (2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1400
  • Hydroxypropyl-beta-cyclodextrin,97%
  • (2-Hydroxypropyl)-beta-cyclode
  • (2-Hydroxypropyl)-beta-cyclodextrin, avge. MW ca 1400
  • (2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480
  • (2-Hydroxypropyl)-β-cyclodextrin ,97%
  • Hydroxypropyl Betadex (200 mg)
  • Hydroxypropyl-beta-cyclodextrin, 97% 100GR
  • Hydroxypropyl-beta-cyclodextrin, 97% 25GR
  • (2-Hydroxypropyl)-^b-cyclodextrin, MW ca 1250-1480
  • β-Cyclodextrin 2-Hydroxypropyl Ethers
  • HPBCD/HPCD
  • (2-Hydroxypropyl)-beta-cyclodextrin ,EP
  • Hydroxypropyl-b-cyclodextrin EP
  • Hydroxypropyl-b-cyclodextrin USP
  • (2-Hydroxypropyl)-beta-cyclodextrin average Mw ~1,380
  • (2-Hydroxypropyl)-beta-cyclodextrin average Mw ~1,460
  • (2-Hydroxypropyl)-beta-cyclodextrin, 97+%
  • 2-Hydroxypropyl-beta-cyclodextrin in stock Factory
  • 128446-35-5
  • 94035-06-2
  • 94535-02-6
  • C63H112O42
  • C54H102O39
  • C42H70nO35C3H7On
  • C6H9O57C3H7On
  • Cyclodextrins
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