3'-Chlorpropiophenon

3'-Chlorpropiophenon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.

Chemische Eigenschaften

WHITE TO LIGHT YELLOW CRYSTALLINE SOLID

Verwenden

3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.

Application

3′-Chloropropiophenone can be used as a reactant to synthesize:
(S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
(S)-Dapoxetine, a selective serotonin reuptake inhibitor.

synthetische

4.86 g (0.2 mol) of magnesium turnings, 30 ml of dry diethyl ether and a grain of iodine are placed in a one liter three-necked round-bottomed flask equipped with a condenser, a calcium chloride drying tube, a pressure equalizing funnel and a magnetic stirrer; the flask is purged with nitrogen, and 21.8 g (0.2 mol) of ethyl bromide in 30 ml of dry diethyl ether are then added. The mixture is then heated under reflux for one hour and left to cool. At ambient temperature, 16.51 g (0.12 mol) of 3-chlorobenzonitrile in 70 ml of dry diethyl ether are then added. A copious precipitate forms. The mixture is stirred overnight at ambient temperture and then cooled in an ice bath and hydrolysed by slowly adding 50 ml of water and then about 100 ml of 6N hydrochloric acid until the pH is acid. The mixture is stirred for one and a half hours and then extracted with ethyl acetate. The organic extract is then washed twice with water, dried and concentrated on a rotary evaporator. This gives 26 g of an orange oil, which is concentrated in vacuo to give about 18.2 g of ochre crystals of 3'-chloropropiophenone melting at about 40° C.
Literature source US04690931

3'-Chlorpropiophenon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3'-Chlorpropiophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Jinan Qinmu Fine Chemical Co.,Ltd.	+8618660799346	sales@qinmuchem.com	China	1009	58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD	+8617731987558	xingjiu@xingjiubiotech.com	China	990	58
Nanjing Deda New Material Technology Co., Ltd	+8613223293093	bella@njdeda.com	China	81	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Hunan aslsen technology co.,ltd	+8619313031929	aslsd@aslsen.com	China	128	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	298	55

34841-35-5(3'-Chlorpropiophenon)Verwandte Suche:

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• 3-CHLOROPHENYL ETHYL KETONE
• (3-CHLOROPHENYL)PROPAN-1-ONE
• 1-(3-CHLOROPHENYL)-1-PROPANONE
• 3-CHLORO-1-PHENYL-PROPANONE
• 3-CHLOROPROPIOPHENONE M-CHLORO PROPIOPHENONE
• 3-Chloro-Propiophenone(M-ChloroProiophenone)
• M-ChloroProiophenone
• 3'-Chloropropiophenone
• 3'-Chloropropiopheno
• Between chloropropiophenone
• 1-Propanone, 1-(3-chlorophenyl)-
• Bupropion Des-t-ButylaMino IMpurity
• 3&priMe
• 3'-chloroacetone
• ：3’-Chloropropiophenone，1-(3-chlorophenyl)propan-1-one
• 3 '- chlorobenzene acetone
• 3'-Chloropropiophenone Synonyms 1-(3-Chlorophenyl)-1-propanone
• 3'-Chloropropiophenone, 97+%
• Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
• Bupropion Impurity 14 (3'-Chloropropiophenone)
• Bupropion Impurity 22
• Bupropion Hydrochloride Impurity Ⅰ（3-chloropropiophenone）
• Chloropropiophenone Chloropropiophenone
• MCPP 3'-Chloropropiophenone
• 3'-Chloropropiophenone USP/EP/BP
• 3'-Chloropropiophenone/META CHLOROPROPIOPHENONE
• 3’-ChloropropiophenoneQ: What is 3’-Chloropropiophenone Q: What is the CAS Number of 3’-Chloropropiophenone Q: What is the storage condition of 3’-Chloropropiophenone Q: What are the applications of 3’-Chloropropiophenone
• 1-(3-Chlorphenyl)propan-1-on
• Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
• M-CHLOROPROPIOPHENONE
• MCPP
• 1-(3-chlorophenyl)propan-1-one
• Bupropion Hydrochloride Impurity Ⅰ (3-chloropropiophenone)
• DES-T-BUTYLAMINO IMPURITY
• Meta Chloropropiophenone
• 3-chlorophenone
• Bupropion Des-tert-butylamine Impurity
• Bupropion Intermediate
• Meta - Chloropropiophenone ( 3 - Chloropropiophenone )
• Chloropropiophenone (10 mg) (1-(3-Chlorophenyl)propan-1-one) (COLD SHIPMENT REQUIRED)
• 1-(3-Chlorophenyl)propan-1-one (Bupropion Impurity)
• 3'-Chloropropiophenone, ≥ 98.0%
• 3'-Chloropropiophenone
• Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
• 34841-35-5
• Organic Building Blocks
• Ketones
• Building Blocks
• Carbonyl Compounds
• C9
• KETONE
• C9
• Carbonyl Compounds
• Ketones
• Aromatic Propiophenones (substituted)
• Aromatic Ketones (substituted)
• Aromatic Halides (substituted)
• 34841-35-5