Vancomycin hydrochloride
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- CAS-Nr.
- 1404-93-9
- Englisch Name:
- Vancomycin hydrochloride
- Synonyma:
- VANCOMYCIN HCL;VANCOR;Meek;VANCOCIN;LYPHOCIN;Vancocyn;mg/mL in DMSO;VancoMycin HC1;ycin hydrochloride;vancocinehydrochloride
- CBNumber:
- CB8117577
- Summenformel:
- C66H76Cl3N9O24
- Molgewicht:
- 1485.72
- MOL-Datei:
- 1404-93-9.mol
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Vancomycin hydrochloride Eigenschaften
- Schmelzpunkt:
- >190°C (dec.)
- alpha
- [α]D20 -30～-40゜ (c=1, H2O)
- Flammpunkt:
- 87℃
- storage temp.
- 2-8°C
- Löslichkeit
- H2O: 50 mg/mL, clear, yellow
- Aggregatzustand
- Powder
- Farbe
- colorless to faint yellow or tan
- PH
- pH (50g/l, 25℃) : 2.5～4.5
- Wasserlöslichkeit
- Soluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
- Sensitive
- Hygroscopic
- Merck
- 13,9995
- BRN
- 3704657
- Stabilität:
- Hygroscopic
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
43-42 |
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| S-Sätze: |
36/37-24/25-22-36 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
YW4380000 |
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| F |
8-10-21 |
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| HS Code |
29419090 |
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| Toxizität |
LD50 in mice (mg/kg): 489 i.v.; 1734 i.p.; 5000 s.c.; 5000 orally (Anderson) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P284 |
Atemschutz tragen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P342+P311 |
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Vancomycin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Vancomycin is a glycopeptide antibiotic identified for its utility in the treatment of gram-
positive bacteria, including penicillin-
resistant staphylococci. It acts by binding to bacterial cell wall protein precursors, interfering with continuing protein synthesis. Vancomycin resistance in staphylococcal species has recently emerged as a clinical issue.
Chemische Eigenschaften
off white powder
Verwenden
Vancomycin hydrochloride is the salt of a glycopeptide antibiotic isolated from Amycolatopsis orientalis in 1956. Vancomycin exhibits potent activity against Gram positive bacteria and is highly effective against MRSA in vitro and in vivo. Vancomycin interferes with cell wall synthesis by binding to D-alanine-D-alanine residues.
Allgemeine Beschreibung
The isolation of the glycopeptide antibiotic vancomycin(Vancocin, Vancoled) from Streptomyces orientalis (renamedA. orientalis) was described in 1956 by McCormick et al.232The organism originally was obtained from cultures of anIndonesian soil sample and subsequently has been obtainedfrom Indian soil. Vancomycin was introduced in 1958 as anantibiotic active against Gram-positive cocci, particularlystreptococci, staphylococci, and pneumococci. It is not activeagainst Gram-negative bacteria, with the exception ofNeisseria spp. Vancomycin is recommended for use wheninfections fail to respond to treatment with the more commonantibiotics or when the infection is known to be caused by aresistant organism. It is particularly effective for the treatmentof endocarditis caused by Gram-positive bacteria.
Vancomycin hydrochloride is a free-flowing, tan tobrown powder that is relatively stable in the dry state. It isvery soluble in water and insoluble in organic solvents. Vancomycin inhibits cell wall synthesis by preventingthe synthesis of cell wall mucopeptide polymer. It does soby binding with the D-alanine-D-alanine terminus of theuridine diphosphate-N-acetylmuramyl peptides requiredfor mucopeptide polymerization.236 Details of the bindingwere elucidated by the elegant NMR studies of Williamson.
Vancomycin hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Vancomycin hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 538)Lieferanten
1404-93-9()Verwandte Suche:
- vancocinehydrochloride
- LYPHOCIN
- Vancomycin Hydrochloride (4 vials, each vial contains 99,300 mcg of vancomycin activity)
- Vancomycin Hydrochloride (4 vials, each vial contains 100,500 mcg of vancomycin activity)
- VANCOMYCIN, HYDROCHLORIDE, STREPTOMYCES ORIENTALIS
- VANCOCIN
- VANCOCIN HYDROCHLORIDE
- VancoMycin HC1
- VancoMycin hydrochloride, froM StreptoMyces orientalis, >=900 μg/Mg
- Vancomycin supplement
- Vancomycin hydrochloride, Antibiotic for Culture Media Use Only
- Balcoran, Diatracin, Fibrantin, HanoMycin, Ledervan, Lyphocin, Vancoled, Vancocin, Vancocine
- VANCOMYCIN HCL, STREPTOMYCES ORIENTALIS
- VANCOMYCIN HYDROCHLORIDE
- VancomycinHCl,Streptomycesorientalis,Cellculturetested
- Vanconycin monodrochloride tetrahydrate
- VANCOMYCIN HYDROCHLORIDE FROM STREPTO-MY CES ORIENTALIS
- VANCOMYCIN HYDROCHLORIDE PLANT CELL*CULT URE TESTED
- VANCOMYCIN HYDROCHLORIDE, BIOTECHNOLOGY
- VANCOMYCIN HYDROCHLORIDE USP
- VANCOMYCIN HCL USP(CRM STANDARD)
- VANCOMYCIN HYDROCHLORIDE EP STANDARD
- Vancomycin hydrochloride, >900 microgram/mg
- Meek
- Vancocyn
- Vancomycin monohydrochloride tetrahydrate
- ycin hydrochloride
- VANCOMYCIN HYDROCHLORIDE 1000 UG/MG BIOTECH GRADE
- VANCOMYCIN HYDROCHLORIDE USP LARGER THAN 1050 UG MG
- Vancomycin Hydrochloride Lyophilised Process
- Vancomycin hydrochloride.usp.ep
- Vancomycin hydrocloride
- Vancomycin hydrochloride, USP,potency: ≥900μg/mg
- Sterile Vancomycin Hcl
- Vancomycin hydrochloride CRS
- Vancomycin Hydrochloride (4 vials, each vial contains 98,800 mcg of vancomycin activity)
- Vancomycin hydrochloride salt
- (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(4S,5S,6R)-3-{[(4S,5R,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-22-(carbamoylmethyl)-47,49-dichloro-2,18,32,35,37-pentahydroxy-19-[(2R)-4-methyl-2-(methylazaniumyl)pentanamido]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2^{3,6}.2^{14,17}.1^{8,12}.1^{29,33}.0^{10,25}.0^{34,39}]pentaconta-3,5,8(48),9,11,14,16,29,31,33(45),34,36,38,46,49-pentadecaene-40-carboxylate hydrochloride
- Vancomycin hydrochloride USP/EP/BP
- Vancomycin Hydrochloride,Vancomycin HCL
- Antibiotics and Antimycotics Vancomycin HCl CAS 1404-93-9
- Vancomycin hydrochloride, from Streptomyces orientalis, ≥80% (HPLC)
- Vancomycin Hydrochloride(V0045000)
- Vancomycin HydrochlorideQ: What is
Vancomycin Hydrochloride Q: What is the CAS Number of
Vancomycin Hydrochloride Q: What is the storage condition of
Vancomycin Hydrochloride Q: What are the applications of
Vancomycin Hydrochloride
- Vancomycin-d10 hydrochloride
- mg/mL in DMSO
- Vancomycin Hydrochloride (VNC), 90%
- Vancomycin Hydrochloride (1709007)
- VANCOR
- VANCOMYCIN HCL
- Vancomycin, hydrochloride (8CI, 9CI, ACI)
- (3S,6R,7R,22R,23S,26S,36R,38aR)-3-(2-Amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-methyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid xhydrochloride
- Vancomycin HCl - pharma grade
- Vancomycin Hydrochloride (500 mg)
- 1404-93-9
- 1404-39-9
- C66H75Cl2N9O24xClH
- C66H75Cl2N9O24譎Cl
