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Norepinephrin Produkt Beschreibung

Norepinephrine Struktur
51-41-2
CAS-Nr.
51-41-2
Bezeichnung:
Norepinephrin
Englisch Name:
Norepinephrine
Synonyma:
SSXS-2;aktamin;adrenor;levophed;sympathine;l-arternol;norartrinal;L-ARTERENOL;-NoradrenaL;(-)-noradrec
CBNumber:
CB8346810
Summenformel:
C8H11NO3
Molgewicht:
169.18
MOL-Datei:
51-41-2.mol

Norepinephrin Eigenschaften

Schmelzpunkt:
220-230°C
alpha 
D25 -37.3° (c = 5 in water with 1 equiv HCl)
Siedepunkt:
298.46°C (rough estimate)
Dichte
1.2435 (rough estimate)
Brechungsindex
1.5100 (estimate)
storage temp. 
2-8°C
Aggregatzustand
crystalline
pka
8.64(at 25℃)
Farbe
off-white to tan
Wasserlöslichkeit
Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether.
Sensitive 
Air & Light Sensitive
Merck 
14,6695
BRN 
4231961
Stabilität:
Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20C.
CAS Datenbank
51-41-2(CAS DataBase Reference)
EPA chemische Informationen
Norepinephrine (51-41-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+,C,F
R-Sätze: 26/27/28-34-11-28
S-Sätze: 28-36/37-45-36/37/39-26-16-20
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS-Nr. DN5950000
8-10-23
HazardClass  6.1
PackingGroup  II
HS Code  29225090
Giftige Stoffe Daten 51-41-2(Hazardous Substances Data)
Toxizität dni-hmn:oth 5800 nmol/L CNREA8 40,1414,80
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H310 Lebensgefahr bei Hautkontakt. Acute toxicity,dermal Category 1, 2 Achtung P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H330 Lebensgefahr bei Einatmen. Akute Toxizität inhalativ Kategorie 1 Achtung P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.
P321 Besondere Behandlung
P302+P350 BEI KONTAKT MIT DER HAUT: Behutsam mit viel Wasser und Seife waschen.
P405 Unter Verschluss aufbewahren.

Norepinephrin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R34:Verursacht Verätzungen.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

solid

Verwenden

Vascular active drug resistance to shock

Verwenden

An adrenergic neurotransmitter.

Verwenden

Norepinephrine is used for increasing cardiac constriction and for the necessary elevation of blood pressure after sharp decline, which can result from surgical intervention or trauma.

Definition

ChEBI: The R-enantiomer of noradrenaline.

Trademarks

Levophed (Hospira);Noradrec;Xylotox.

Weltgesundheitsorganisation (WHO)

Vasoconstrictor agents have been in use for many years to prolong duration of action of local anaesthetics, particularly in dentistry. Combination products containing epinephrine or levarterenol in concentrations of 1:80,000 or less remain widely available. See also WHO comment for epinephrine.

Biologische Funktion

Most central noradrenergic neurons are located in the nucleus locus ceruleus of the pons and in neurons of the reticular formation. Fibers from these nuclei innervate a large number of cortical, subcortical, and spinomedullary fields. Many functions have been ascribed to the central noradrenergic neurons, including a role in affective disorders (see Chapter 33), in learning and memory, and in sleep–wake cycle regulation.The mammalian CNS contains both α- and β-adrenoceptors.

Allgemeine Beschreibung

Norepinephrine (NE, Levophed) differs from DA onlyby addition of a 1-OH substituent (β-OH-DA) and from Eonly by lacking the N-methyl group. Like DA, it is polar andrapidly metabolized by both COMT and MAO, resulting inpoor oral bioavailability and short DOA (1 or 2 minutes evenwhen given intravenously). It is a stimulant of α1-, α2-, andβ1-adrenoceptors (notice that lacking the N-methyl group resultsin lacking β2- and β3-activity). It is used to counteractvarious hypotensive crises, because its α-activity raisesblood pressure and as an adjunct treatment in cardiac arrestbecause its β-activity stimulates the heart. It has limitedclinical application caused by the nonselective nature of itsactivities.

Hazard

May cause local tissue necrosis, headache, bradycardia, hypertension; poison; teratogen; mutagen.

Pharmakologie

Norepinephrine is the primary neurotransmitter produced and released by adrenergic neurons, and in literature it is also described as and called () noradrenaline or levarterenol. This vasopressor catecholamine reduces both the resistance and capacity of blood vessels by stimulating α-adrenoreceptors and having a direct cardiostimulatory effect, which is accomplished by activation of β1-adrenoreceptors. Norepinephrine exhibits significantly less activity than epinephrine as a drug for widening blood vessels through the activation of β2-adrenoreceptors. Elevation of both stylistic and diastolic blood pressure is a typical reaction to intravenous introduction of norepinephrine.

Sicherheitsprofil

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A sympathomimetic vasopressor. When heated to decomposition it emits toxic fumes of NOx.

Chemical Synthesis

Norepinephrine, L-1-(3,4-dihydroxyphenyl)-2-aminoethanol (11.1.4), is synthesized by two methods starting from 3,4-dihydroxybenzaldehyde. According to the first method, the indicated aldehyde is transformed into the cyanohydrin (11.1.3) by reaction with hydrogen cyanide, which is then reduced into norepinephrine (11.1.5).

The second method consists of the condensation of diacetate of the same aldehyde with nitromethane, which forms (3,4-diacetoxyphenyl)-2-nitroethanol (11.1.5). Then the nitro group is reduced and the product (11.1.6) is hydrolyzed into the desired norepinephrine (11.1.4) [4,9,13,14].

läuterung methode

Recrystallise adrenor from EtOH and store it in the dark under N2. [pKa, Lewis Brit J Pharmacol Chemother 9 488 1954, UV: Bergstr.m et al. Acta Physiol Scand 20 101 1950, Fluorescence: Bowman et al. Science NY 122 32 1955, Tullar J Am Chem Soc 70 2067 1948.] The L-tartrate salt monohydrate has m 102-104.5o, [] D -11o (c 1.6, H2O), after recrystallisation from H2O or EtOH. [Beilstein 13 III 2382.]

Norepinephrin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Norepinephrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 222)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
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18017610038
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+8619930503282
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Standardpharm Co. Ltd.
86-714-3992388
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Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58

51-41-2(Norepinephrin)Verwandte Suche:


  • (-)-alpha-(aminomethyl)protocatechuylalcohol
  • (-)-noradrec
  • 4-(2-amino-1-hydroxyethyl)-2-benzenedio(r)-
  • adrenor
  • Adrenaline Impurity 2(Adrenaline EP Impurity B)
  • aktamin
  • arterenolfreebase(noradrenaline)
  • d-(-)-noradrenaline
  • l-1-(3,4-dihydroxyphenyl)-2-aminoethanol
  • l-2-amino-1-(3,4-dihydroxyphenyl)ethanol
  • l-3,4-dihydroxyphenylethanolamine
  • l-alpha-(aminomethyl)-3,4-dihydroxybenzylalcohol
  • levoarterenol
  • levonoradrenaline
  • levonorepinephrine
  • levophed
  • noradrenalina
  • noradrenline
  • norartrinal
  • norepirenamine
  • sympathine
  • L-NOREPINEPHRINE
  • L-NORADRENALINE
  • LEVARTERENOL
  • L-ARTERENOL
  • (-)-ARTERENOL
  • ARTERENOL (-)-
  • (R)-4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL
  • NORADRENALIN
  • (-)-NORADRENALINE
  • NORADRENALINE
  • (-)-NOREPINEPHRINE
  • NOREPINEPHRINE
  • l-arternol
  • 4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol
  • (-)-a-(Aminomethyl)protocatechuyl alcohol
  • (R)-(-)-Norepinephrine
  • (R)-Norepinephrine
  • 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-
  • 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- (9CI)
  • l-a-(Aminomethyl)-3,4-dihydroxybenzyl alcohol
  • Nor-Epirenan
  • (−)-Norepinephrine
  • L-Arternol=L-Norepinephrine
  • (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol
  • 4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol
  • Epinephrine Impurity B
  • Noradrenaline(Norepinephrine,NA,NE)
  • ()-Norepinephrine,(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol
  • Noradrenaline API
  • Norepinephrine Hydrochloride (Solution)
  • Norepinephrine HCl (solution)
  • -NoradrenaL
  • Norepinephrine USP/EP/BP
  • Norepinephrine (Noradrenaline)
  • Norepinephrine USP
  • (?)-Norepinephrine
  • SSXS-2
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