1,2-Dihydroxybenzol Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH. VERFäRBEN SICH BRAUN BEI KONTAKT MIT LUFT UND LICHT.
CHEMISCHE GEFAHREN
Beim Verbrennen Bildung reizender Rauche. Reagiert mit Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV: 5 ppm (als TWA); Hautresorption; Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Haut, die Atemwege und den Verdauungstrakt. Die Substanz verätzt die Augen. Möglich sind Auswirkungen auf das Zentralnervensystem mit nachfolgender Depression, Krämpfen und Atemversagen. Exposition kann zu Blutdrucksteigerung führen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
R-Sätze Betriebsanweisung:
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37:Geeignete Schutzhandschuhe tragen.
Chemische Eigenschaften
Off-white powder
Verwenden
Catechol is used in photography, in dyeing fur, and as a topical antiseptic.
Vorbereitung Methode
Catechol may be obtained by the fusion of o-phenolsulfonic
acid with alkali, by heating chorophenol with a
solution of sodium hydroxide at 200°C in an autoclave, or
by cleavage of the methyl ether group of guaiacol (obtained
from beechwood tar) with hydriodic acid.
Definition
A colourless crystalline
PHENOL containing two hydroxyl groups. It
is used in photographic developing.
Allgemeine Beschreibung
Solid; white; odorless. Sinks and mixes with water.
Air & Water Reaktionen
Turns brown on exposure to air and light, especially when moist. Water soluble. Aqueous solutions soon turn brown on exposure to air and light.
Reaktivität anzeigen
POISONOUS GASES MAY BE PRODUCED WHEN HEATED. Pyrocatechol may form toxic fumes at high temperatures. [USCG, 1999]. Pyrocatechol can react with acid chlorides, acid anhydrides, bases and oxidizing agents. Pyrocatechol reacts violently on contact with concentrated nitric acid. Pyrocatechol acts as a reducing agent .
Hazard
Strong irritant. Toxic by skin absorption.
Eye and upper respiratory tract irritant, and der-
matitis. Possible carcinogen.
Health Hazard
Acute oral and percutaneous toxicity of pyrocatechol is greater than that of phenol; inhalation toxicity is less than that of phenol. The toxic symptoms include weakness, muscular pain, dark urine, tremor, dyspnea, and convulsions. Large amounts can produce degenerative changes in renal tubules. Large doses can cause death due to respiratory failure. Skin contact can cause eczematous dermatitis.
LD50 value, oral (rats): 260 mg/kg
LD50 value, skin (rabbits): 800 mg/kg.
Brandgefahr
Combustible. POISONOUS GASES MAY BE PRODUCED WHEN HEATED. May form toxic fumes at high temperatures.
Sicherheitsprofil
Poison by ingestion,
subcutaneous, intraperitoneal, intravenous,
and parenteral routes. Moderately toxic by
skin contact. Experimental reproductive
effects. Can cause dermatitis on skin
contact. An allergen. Human mutation data
reported. Questionable carcinogen. Systemic
effects sirmlar to those of phenol.
Combustible when exposed to heat or
flame; can react vigorously with oxidizing
materials. Hypergolic reaction with
concentrated nitric acid. To fight fire, use
water, CO2, dry chemical. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also PHENOL.
mögliche Exposition
Used as a chemical intermediate;
pharmaceutical and veterinary drug; as an antiseptic; in
photography; in dyestuff manufacture and application. It is
also used in electroplating, in the formulation of specialty
inks; in antioxidants; and light stabilizers.
Carcinogenicity
Catechol has been extensively
studied for its role in carcinogenesis of the rat glandular
stomach; it was concluded that pyrocatechol is
carcinogenic. When rats and mice were administered
0.8% pyrocatechol in their feed for life, there was an increase
in glandular stomach adenocarcinoma in both male and
female rats. Pyrocatechol also caused hyperplasia of the
glandular stomach in both rats and mice, a mechanism
that could cause promotion of carcinogen-initiated
cells; no effects on the esophagus or urinary bladder
were reported. There were no cutaneous neoplasms when
pyrocatechol was applied in dermal studies. Catechol
may be classified as a cocarcinogen because it enhanced the
number and/or incidence of lesions in the stomach induced
by several carcinogenic nitrosamines and cutaneous neoplasms
when administered dermally together with several
carcinogens.
Versand/Shipping
UN 2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
läuterung methode
Crystallise catechol from *benzene or toluene and sublime it in vacuo. [Rozo et al. Anal Chem 58 2988 1986, Beilstein 6 IV 5557.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides.
1,2-Dihydroxybenzol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Chlor-1,3-benzodioxol
[[o-(Allyloxy)phenoxy]methyl]oxiran
3,4-(Methylendioxy)phenylacetonitril
Propoxur (ISO)
Adrenalon
4-(1,1-Dimethylethyl)-1,2-benzoldiol
1-Iodheptan
2,3-Dihydro-2,2-dimethylbenzofuran-7-ol
3,4,5,6-Tetrabrom-o-benzochinon
2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONYL CHLORIDE
1,3,2-Benzodioxaborol
2,3-DIHYDRO-1,4-BENZODIOXIN-2-METHANOL 4-METHYLBENZENESULFONATE
4-Brombrenzcatechin
Piperonal
1,2-Diethoxybenzol
5-Diethylamino-2-(5-brom-2-pyridylazo)phenol
Isoprenalin
1-Bromo-1-cyclopentene
1,2-Methylendioxybenzol
Carbofuran (ISO)
1,4-Benzodioxan-2-methanol
2-[(2-METHYL-2-PROPENYL)OXY]-PHENOL
1,2-Dimethoxybenzol
2,3,5,6,8,9,11,12-Octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin
Pyrocatechol Violet
DIETHOFENCARB
o-(Allyloxy)phenol
PIPERONYL FORMALDEHYDE
4'-FORMYLBENZO-15-CROWN 5-ETHER
BENZO[1,3]DIOXOLE-5-SULFONYL CHLORIDE
1,4-Dihydroxybenzol
2-Chlor-3',4'-dihydroxyacetophenon
3-Ethoxy-4-hydroxybenzaldehyd
o-Isopropoxyphenol
1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]ethan-1-on
