Histrelin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced
as a first-line therapy for the treatment of central precocious puberty. When administered over
a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular
steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with
progestational agents, histrelin appears to have decelerating effects on skeletal maturation
allowing more statural growth and significantly increased final adult height. Histrelin has also
been used to treat other disorders including endometriosis, polycystic ovarian disease,
uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent
porphyria.
Verwenden
LHRH agonist.
Definition
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro
in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Histrelin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
