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Histrelin Produkt Beschreibung

Histrelin Struktur
76712-82-8
CAS-Nr.
76712-82-8
Englisch Name:
Histrelin
Synonyma:
orf17070;Supprelin;RWJ-17070;HISTRELIN;histrelin acetate;Histreline Acetate;(HIS(BZL)6)-HISTRELIN;(DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH;((imbl)-d-his(sub6),pro(sub9)-net)lhrh;(DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
CBNumber:
CB8480046
Summenformel:
C66H86N18O12
Molgewicht:
1323.5
MOL-Datei:
76712-82-8.mol

Histrelin Eigenschaften

alpha 
D20 -33.9° (c = 1 in acetic acid)
storage temp. 
−20°C
Aggregatzustand
powder
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 60
S-Sätze: 53-22-36/37/39-45
WGK Germany  3
RTECS-Nr. OK6370800
Giftige Stoffe Daten 76712-82-8(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Histrelin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Beschreibung

Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.

Originator

Johnson & Johnson (U.S.A.)

Verwenden

LHRH agonist.

Definition

ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

Trademarks

Supprelin (Roberts Pharmaceutical).

Histrelin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Histrelin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 79)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2258 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Cellmano Biotech Limited
+86-551-65326643
+86-551-65326641 info@cellmano.com CHINA 1044 58
Creative Peptides
info@creative-peptides.com United States 6249 56
Arden pharmaceutical &chemical Co., Ltd +86-(0)533-3595900 13793319233
+86-(0)533-3595900 info@chems.com.cn China 669 61
Chengdu Ai Keda Chemical Technology Co., Ltd. 4008-755-333 ; 028-86676798 ; 028-86757656
028-86757656 aikeshiji@163.com China 9755 55
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12341 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
+86 21 50676805 contact@trustwe.com China 9920 58

76712-82-8()Verwandte Suche:


  • 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
  • Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
  • 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
  • RWJ-17070
  • Supprelin
  • 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
  • Histreline Acetate
  • ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
  • (n-ethyl-l-prolinamide)-10-deglycinamide-
  • 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
  • orf17070
  • PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
  • PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
  • PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET
  • (HIS(BZL)6)-HISTRELIN
  • HISTRELIN
  • histrelin acetate
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
  • [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
  • 76712-82-8
  • C66H86N18O12
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • LH-RH
  • Peptides
  • Releasing Factors
  • Peptide
  • hormones
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