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GANAXOLONE

GANAXOLONE Struktur
38398-32-2
CAS-Nr.
38398-32-2
Englisch Name:
GANAXOLONE
Synonyma:
Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone;1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
CBNumber:
CB8498146
Summenformel:
C22H36O2
Molgewicht:
332.52
MOL-Datei:
38398-32-2.mol
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GANAXOLONE Eigenschaften

Schmelzpunkt:
190-192°
alpha 
D +103°
Siedepunkt:
434.8±18.0 °C(Predicted)
Dichte
1.036±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO: ~4.2 mg/mL
Aggregatzustand
solid
pka
15.18±0.70(Predicted)
Farbe
white

Sicherheit

S-Sätze: 22-24/25
WGK Germany  3
RTECS-Nr. TU4384700

GANAXOLONE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.

Verwenden

Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.

Biologische Aktivität

Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

GANAXOLONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1-((2R,10S,13S,17S)-10,13-dimethylhexadecahydrospiro[cyclopenta[a]phenanthrene-3,2-oxiran]-17-yl)ethanone(WXG00316) 3-β-Hydroxy-5-α-pregnan-20-on 5-α-Pregnan-3,20-dion Methylmagnesiumbromid Pregnenolon Methylmagnesiumchlorid

Downstream Produkte

Pregnan-20-one, 3-hydroxy-3-methyl-, (3β,5α)-

GANAXOLONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 64)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hunan Yuanye Pharmaceutical Co., Ltd.
+8615857615745
 2675013845@qq.com China 87 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131981 58
Hunan Yuanye Pharmaceutical Co., Ltd. 0731-85589467; 13574065797
 2675013845@qq.com China 33 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636
 wtx@bayeebio.com China 253 61
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
  • 3α-hydroxy-3β-methyl-5α-pregnan-20-one
  • (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
  • 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
  • (3α,5α)-3-Hydroxy-3-methylpregnan-20-one
  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
  • Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-
  • Fampridine Impurity 80
  • 5α-PREGNAN-3β-METHYL-3α-OL-20-ONE
  • 1-[(Chemicalbook3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
  • 3α-hydroxy-3β-methyl-5α-pregnan-20-one
  • 5α-PREGNAN-3β-METHYL-3α-
  • 38398-32-2
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