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GANAXOLONE

GANAXOLONE 구조식 이미지

카스 번호:: 38398-32-2

상품명:: GANAXOLONE

동의어(영문):: Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone;1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

CBNumber:: CB8498146

분자식:: C22H36O2

포뮬러 무게:: 332.52

MOL 파일:: 38398-32-2.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 64

GANAXOLONE 속성

녹는점: 190-192°

알파: D +103°

끓는 점: 434.8±18.0 °C(Predicted)

밀도: 1.036±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: DMSO: ~4.2mg/mL

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 15.18±0.70(Predicted)

색상: 하얀색

안전

안전지침서	22-24/25
WGK 독일	3
RTECS 번호	TU4384700

GANAXOLONE C화학적 특성, 용도, 생산

개요

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABA_A receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABA_A receptor complexes containing α₁, α₂, α₃, β₂, and γ_2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.

용도

Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.

생물학적 활성

Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

GANAXOLONE 준비 용품 및 원자재

원자재

1-((2R,10S,13S,17S)-10,13-dimethylhexadecahydrospiro[cyclopenta[a]phenanthrene-3,2-oxiran]-17-yl)ethanone(WXG00316) ALLOPREGNANOLONE 5α-Pregnane-3,20-dione 메틸마그네슘브로마이드 Pregnenolone 메틸마그네슘 염화물

준비 용품

Pregnan-20-one, 3-hydroxy-3-methyl-, (3β,5α)-

GANAXOLONE 공급 업체

글로벌( 64)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hunan Yuanye Pharmaceutical Co., Ltd.	+8615857615745	2675013845@qq.com	China	87	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Hunan Yuanye Pharmaceutical Co., Ltd.	0731-85589467; 13574065797	2675013845@qq.com	China	33	58
Bayee Biotech (Anqing) Co., Ltd.	0556-5032306 18917961636	wtx@bayeebio.com	China	253	61
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

GANAXOLONE 관련 검색:

Sofalcone GANAXOLONE