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Salmeterol Produkt Beschreibung

Salmeterol Struktur
89365-50-4
CAS-Nr.
89365-50-4
Englisch Name:
Salmeterol
Synonyma:
CS-380;SN408D;gr33343x;GR 33343;SAMETEROL;Astmerole;SALMETEROL;BNKY006-SX05;Salmeterol, >=99%;SalmeterolXenofoate
CBNumber:
CB9186866
Summenformel:
C25H37NO4
Molgewicht:
415.57
MOL-Datei:
89365-50-4.mol

Salmeterol Eigenschaften

Schmelzpunkt:
75.5-76.5°
Siedepunkt:
603.0±55.0 °C(Predicted)
Dichte
1.112±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
9.99±0.31(Predicted)
CAS Datenbank
89365-50-4(CAS DataBase Reference)

Sicherheit

RTECS-Nr. CZ6457000
Giftige Stoffe Daten 89365-50-4(Hazardous Substances Data)

Salmeterol Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Bronchodilator.

Definition

ChEBI: A phenol having a hydroxymethyl group at C-2 and a 1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl group at C-4; derivative of phenylethanolamine.

Allgemeine Beschreibung

Salmeterol has an N-phenylbutoxyhexyl substituent incombination with a β-OH group and a salicyl phenyl ring foroptimal direct-acting β2-receptor selectivity and potency. Ithas a potency similar to that of ISO. This drug associateswith the β2-receptor slowly resulting in slow onset of actionand dissociates from the receptor at an even slower rate. It is resistant to both MAO and COMT and highly lipophilic(log P=3.88). It is thus very long acting (12 hours), aneffect also attributed to the highly lipophilic phenylalkylsubstituent on the nitrogen atom, which is believed to interactwith a site outside but adjacent to the active site.

Hazard

A poison by inhalation.

Biologische Aktivität

Potent and selective β 2 -adrenoceptor agonist (EC 50 = 5.3 nM); bronchodilator. Unlike other β 2 agonists, binds to exo-site domain of β 2 receptors, producing a slow onset of action and prolonged activation. Also available as part of the β -Adrenoceptor Agonist Tocriset™ .

Mechanism of action

A β2-agonist with a slow onset and extended duration of action is salmeterol. Salmeterol has the same phenyl ring substitution R3 as albuterol but also an unusually long and lipophilic group R1 on the nitrogen. The octanol–water partition coefficient, log P, for salmeterol is 3.88, compared with 0.66 for albuterol. Salmeterol is approximately 50-fold more selective than albuterol for the β2-receptor. Substantial evidence indicates that its long duration of action results from a specific binding interaction (“anchoring”) of the phenyl group at the end of the extended lipophilic side chain with a specific region of the β2-receptor, affording salmeterol a unique binding mechanism.

Clinical Use

Salmeterol usually is prescribed for severe persistent asthma following previous treatment with a short-acting β-agonist, such as albuterol. The noticeable differences between salmeterol and albuterol are the onset of action and their duration of action (Table 13.6). When used regularly every day as prescribed, inhaled albuterol decreases the number and severity of asthma attacks. It is not used, however, for relieving an asthma attack that has already started.

Salmeterol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Salmeterol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 149)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
BIONNA MEDICINE CO.,LTD
18518759099
790226113@qq.com CHINA 52 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21075 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8881 55
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29969 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

89365-50-4()Verwandte Suche:


  • 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL
  • 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino] ethyl]-phenol
  • SALMETEROL
  • (+-)-4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedi
  • 1,3-benzenedimethanol,4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl
  • gr33343x
  • SALMETEROL(SUBJECTTOPATENTFREE)
  • SAMETEROL
  • 1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]- (9CI)
  • 1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, (+-)-
  • GR 33343, 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol
  • SalmeterolXenofoate
  • 4-Hydroxy-3-[hydroxymethyl]phenyl-N-[6-phenylbutoxyhexyl]ethanolamine
  • Salmeterol & Salmeterol Xinafoate
  • 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol
  • 4-[(1R)-1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]aMino}ethyl]-2-(hydroxyMethyl)phenol
  • salmeterol Solution, 100ppm
  • GR 33343
  • Salmeterol, >=99%
  • BNKY006-SX05
  • CS-380
  • Astmerole
  • SN408D
  • [(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]-[6-(4-phenylbutoxy)hexyl]ammonium
  • 1,3-Benzenedimethanol, 4-hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-
  • Salmeterol fandachem
  • Salmeterol USP/EP/BP
  • 89365-50-4
  • C25H34NO4D3
  • C25H37NO4
  • API
  • Aromatic Building Blocks
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