ChemicalBook
Chinese english Germany Japanese Korea

2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Produkt Beschreibung

Hyperoside Struktur
482-36-0
CAS-Nr.
482-36-0
Bezeichnung:
2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on
Englisch Name:
Hyperoside
Synonyma:
HYPERIN;actoside;HYPEROSID;hyperasid;HYPEROSIDE;hyperozide;HYPEROSIDE(P);HYPEROSIDE hplc;Quercetin 3-D-g;Quercetin 3-D-gaL
CBNumber:
CB9240043
Summenformel:
C21H20O12
Molgewicht:
464.38
MOL-Datei:
482-36-0.mol

2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Eigenschaften

Schmelzpunkt:
225-226°C
Siedepunkt:
872.6±65.0 °C(Predicted)
Dichte
1.87±0.1 g/cm3(Predicted)
storage temp. 
-20°C
pka
6.17±0.40(Predicted)
BRN 
5784795
CAS Datenbank
482-36-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-40
S-Sätze: 22-45-36-24/25
WGK Germany  3
RTECS-Nr. DJ3009200
10-23
HS Code  29389090
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Hypericin, which is widely found in various plants, such as Hypericum, Rosaceae, Campanulaceae, Labiatae, Rhododendron, Asteraceae Kwai, Garciniaceae, Leguminosae, Euonymus, and other fruits and whole grass, is a flavonoid compound.

Chemische Eigenschaften

Yellow Solid

Physikalische Eigenschaften

Appearance: yellowish needlelike crystals. Melting point: 227–229 °C. Specific optical rotation: ?83° (c = 0.2, pyridine). Solubility: soluble in ethanol, methanol, acetone, and pyridine. Hydrochloric acid–magnesium powder reaction yielded formation of cherry red; ferric chloride reaction was green; α-naphthol reaction was positive.

History

In 1960, Nair et al. isolated hyperin from redosier dogwood, in which its content is 0.075%. Flavonoids in the treatment of cardiovascular and cerebrovascular diseases play a pivotal role, among which rutin is a typical representative. Isoquetin mainly presents in the leaves of kumquat flowers and the oleander plant kenaf, and it can also be obtained by chemical synthesis. It shows an anti-inflammatory effect through the capillary permeability test and other animal experiments. It also has a toxic effect on the larvae of Chilohabala larvae. It is one of the active ingredients of Hypericum japonicum, which is used in the treatment of hepatitis because of its inhibition of the activities of hepatic enzyme.

Verwenden

A major flavonoid in apple peels; a bioactive constituent of apple peels

Definition

ChEBI: A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.

Indications

This product is available in the British Pharmacopoeia (2017) and the European Pharmacopoeia (9.0th ed.).
Monomeric compounds are currently used clinically. In clinical practice, hypericin is the main active ingredient of proprietary Chinese medicines, such as Acanthopanax capsules, of which Acanthopanax stem and leaf extract are the raw materials for the preparation. Xin’an capsules, prepared with hawthorn leaf extract, are rich in flavonoids, in which hyperoside, a kind of flavonoid, is one of the main components. Qi yue lipid-lowering tablets are prepared from the effective parts of Chinese medicinal herbs such as hawthorn (Nucleation) and Astragalus membranaceus. Flavonoid is one of the main active ingredients in hawthorn, in which hyperoside content is higher. Xinxuening tablets, containing ursolic acid, vitexin rhamnoside, hyperoside, citric acid, and others, is a preparation made from hawthorn and pueraria and other traditional Chinese medicines, in which hawthorn enhances the actions of the medicine. Clinical indications of Xinxuening tablets are coronary heart disease, angina pectoris, chest tightness, palpitations, high blood pressure, arrhythmia, hyperlipidemia, and mental depression.

Pharmakologie

Hyperoside has a protective effect against myocardial ischemia. It achieves its protective effect on the myocardium by reducing the apoptosis rate of myocardial cells, inhibiting myocardial cell lactate dehydrogenase release, enhancing anti-freeradical effect , and inhibiting calcium influx so as to .
Hyperoside has a protective effect against cerebral ischemia. Hyperoside can significantly lower oxygen-free radicals, reduce the content of malondialdehyde and NO in brain tissue, inhibit the decrease of the activity of LDH, SOD and glutathione peroxidase, and hence result in reduced brain energy, and improve the antianoxic ability . At the same time, hyperoside can reduce the degree of cerebral edema in ischemia-reperfusion rats .
Hypericin has a significant local analgesic effect that is weaker than that of morphine and stronger than that of aspirin and does not create dependency; it is a new type of local analgesic. Studies have shown that the analgesic effect of hyperoside occurs by reducing the Ca2 + of the pain nerve, thereby inhibiting high potassium-induced Ca2 + influx, which distinguishes it from morphine and aspirin .
Hyperoside has a significant anti-inflammatory effect and a strong cough effect and inhibits the role of eye aldose reductase, which may be beneficial for the prevention of diabetic cataracts. Hypericin has an obvious protective effect on liver tissue and gastric mucosa , and its mechanism is related to antioxidant activity and the promotion of a normal return of NO level and improvement of SOD activity.
Hyperoside significantly enhances immune function. In vivo, hyperoside has a significant inhibitory effect on spleen B, T lymphocyte proliferation and peritoneal macrophage phagocytosis, and mouse thymus index; in vitro hyperoside, at a concentration of 6.25–100 μg/mL, significantly enhanced B, T lymphocyte proliferation and promoted the production of interleukin 2 in T lymphocytes .
In addition, hypericin still has hypolipidemic and antidepressant pharmacological effects. Its derivative rutin has anti-inflammatory and antiviral effects. Another derivative, quercetin, is effective at inhibiting expectorant, cough, and asthma for use in the treatment of chronic bronchitis, coronary heart disease, and hypertension.

2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 283)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5382 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 372 58

482-36-0(2-(3,4-Dihydroxyphenyl)-3-(β-D-galaktopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-on)Verwandte Suche:


  • hyperasid
  • hyperozide
  • HYPERIN
  • HYPEROSID
  • HYPEROSIDE
  • QUERCETIN-3B-D-GALACTOSIDE
  • QUERCETIN-3-D-GALACTOSIDE
  • QUERCETIN-3-O-GALACTOSIDE
  • QUERCETIN-3-GALACTOSIDE
  • HYPEROSIDE hplc
  • HYPEROSIDE 98.0% BY HPLC
  • QUERCETIN-3-O-BETA-GALACTOSIDE
  • HYPEROSIDE WITH HPLC
  • 2-(3,4-dihydroxyphenyl)-3-(beta-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(.beta.-D-galactopyranosyloxy)-5,7-dihydroxy-
  • HYPEROSIDE(P)
  • 3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-
  • Hyperin, Hyperoside
  • Hyperoside,Hyperin,Quercetin 3-D-galactoside
  • Hyperoside, 98%, from Abelmoschus manihot (L.) Medic.
  • 2-(3,4-dihydroxyphenyl)-3-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-chromene-4,5,7-triol
  • 3,3′,4′,5,7-Pentahydroxyflavone 3-D-galactoside, Hyperin, Hyperoside
  • quercetin 3-O-beta-D-galactopyranoside
  • Hyperoside (50 mg)
  • 2-(3,4-Dihydroxyphenyl)-3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • Hyperoside, Hyperin
  • Hyperin,Quercetin3-galactoside,Quercetin-3-O-galactoside
  • 4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-3-(beta-d-galactopyranosyloxy)-5
  • Hyperoside, froM AbelMoschus Manihot (L.) Medic.
  • Hyperoside Quercetin 3-D-galactoside
  • Hyperoside [Quercetin 3-galactoside]
  • 3,3′,4′,5,7-Pentahydroxyflavone 3-D-galactoside
  • 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1-benzopyran-4-one
  • quercetin 3-O-β-D-galactopyranoside
  • Hyperoside 482-36-0
  • actoside
  • Quercetin 3-D-g
  • Quercetin 3-D-gaL
  • 482-36-0
  • Natural Dyes
  • Biochemicals and Reagents
  • BioChemical
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Carbohydrates & Derivatives
  • Heterocycles
  • Flavanols
Copyright 2019 © ChemicalBook. All rights reserved